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In vitro effects of progesterone and the synthetic progestin medroxyprogesterone acetate on vascular remodeling.
Mol Cell Endocrinol 2019; 498:110543MC

Abstract

In this work we tested the hypothesis whether progesterone (Pg) or the synthetic progestin medroxyprogesterone acetate (MPA) could be involved in the regulation of events involved in vascular remodeling. Results revealed an enhancement in the capillary-like tubes formation induced by both progestogens. Unlike MPA, Pg acts through VEGF, nitric oxide, PI3K and ERK1/2 signaling pathways. However, the MPA effect depends on platelet activation. Under stress conditions, the proangiogenic action of Pg and MPA was sustained. The progestogens exhibit the ability to prevent vascular smooth muscle cells (VSMC) osteogenic transdifferentiation. Besides this antiosteogenic action, on bone cells the progestogens induced osteoblast maturation and mineralization. The mechanism of action of both steroids on vascular and bone cells involves the participation of progesterone receptor. The data presented in this work provide evidence that the progestogens reduce osteogenic-like transdifferentiation of VSMC and promote angiogenesis with a slight different mechanism of action elicited by each steroid.

Authors+Show Affiliations

Instituto de Ciencias Biológicas y Biomédicas del Sur (INBIOSUR), Universidad Nacional del Sur (UNS), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Biología, Bioquímica y Farmacia, UNS, San Juan 670, B8000ICN, Bahía Blanca, Argentina. Electronic address: pcutini@uns.edu.ar.Instituto de Ciencias Biológicas y Biomédicas del Sur (INBIOSUR), Universidad Nacional del Sur (UNS), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Departamento de Biología, Bioquímica y Farmacia, UNS, San Juan 670, B8000ICN, Bahía Blanca, Argentina. Electronic address: massheim@uns.edu.ar.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31421164

Citation

Cutini, Pablo H., and Virginia L. Massheimer. "In Vitro Effects of Progesterone and the Synthetic Progestin Medroxyprogesterone Acetate On Vascular Remodeling." Molecular and Cellular Endocrinology, vol. 498, 2019, p. 110543.
Cutini PH, Massheimer VL. In vitro effects of progesterone and the synthetic progestin medroxyprogesterone acetate on vascular remodeling. Mol Cell Endocrinol. 2019;498:110543.
Cutini, P. H., & Massheimer, V. L. (2019). In vitro effects of progesterone and the synthetic progestin medroxyprogesterone acetate on vascular remodeling. Molecular and Cellular Endocrinology, 498, p. 110543. doi:10.1016/j.mce.2019.110543.
Cutini PH, Massheimer VL. In Vitro Effects of Progesterone and the Synthetic Progestin Medroxyprogesterone Acetate On Vascular Remodeling. Mol Cell Endocrinol. 2019 Aug 14;498:110543. PubMed PMID: 31421164.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro effects of progesterone and the synthetic progestin medroxyprogesterone acetate on vascular remodeling. AU - Cutini,Pablo H, AU - Massheimer,Virginia L, Y1 - 2019/08/14/ PY - 2019/03/28/received PY - 2019/08/12/revised PY - 2019/08/12/accepted PY - 2019/8/20/pubmed PY - 2019/8/20/medline PY - 2019/8/18/entrez KW - Neovascularization KW - Osteoblasts KW - Progestins KW - Vascular calcification KW - Vascular smooth muscle cells SP - 110543 EP - 110543 JF - Molecular and cellular endocrinology JO - Mol. Cell. Endocrinol. VL - 498 N2 - In this work we tested the hypothesis whether progesterone (Pg) or the synthetic progestin medroxyprogesterone acetate (MPA) could be involved in the regulation of events involved in vascular remodeling. Results revealed an enhancement in the capillary-like tubes formation induced by both progestogens. Unlike MPA, Pg acts through VEGF, nitric oxide, PI3K and ERK1/2 signaling pathways. However, the MPA effect depends on platelet activation. Under stress conditions, the proangiogenic action of Pg and MPA was sustained. The progestogens exhibit the ability to prevent vascular smooth muscle cells (VSMC) osteogenic transdifferentiation. Besides this antiosteogenic action, on bone cells the progestogens induced osteoblast maturation and mineralization. The mechanism of action of both steroids on vascular and bone cells involves the participation of progesterone receptor. The data presented in this work provide evidence that the progestogens reduce osteogenic-like transdifferentiation of VSMC and promote angiogenesis with a slight different mechanism of action elicited by each steroid. SN - 1872-8057 UR - https://www.unboundmedicine.com/medline/citation/31421164/In_vitro_effects_of_progesterone_and_the_synthetic_progestin_medroxyprogesterone_acetate_on_vascular_remodeling L2 - https://linkinghub.elsevier.com/retrieve/pii/S0303-7207(19)30245-X DB - PRIME DP - Unbound Medicine ER -