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Research on mechanism of charred hawthorn on digestive through modulating "brain-gut" axis and gut flora.
J Ethnopharmacol 2019; 245:112166JE

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE

Hawthorn is a traditional Chinese medicine for high-calorie-diet-induced dyspepsia (HC-DID) for thousands of years old. Based on traditional Chinese medicine (TCM) theory and clinical and non-clinical trials, its stir-frying processed product, charred hawthorn, possesses better effect. At present, most research mainly focuses on chemical constituents of hawthorn before and after stir-frying process, but there is no relevant action-mechanism study about fragrant odor promoting HC-DID during the stir-frying process of the hawthorn.

AIM OF THE STUDY

The purpose of the present study is to research on mechanism of hawthorn decoction coupled with odor of charred hawthorn on digestive in rats with HC-DID.

MATERIALS AND METHODS

The SPF Kunming (KM) mice and Sprague Dawley (SD) rats were randomly divided into 7 groups: control group, model group, cisapride group, hawthorn group (HT), charred hawthorn group (CHT), odor of charred hawthorn (OCHT), CHT + OCHT group. The rats were modeled as HC-DID, whose treatment by intragastric administration and odor administration. Obvious symptoms of HC-DID were observed. Gastrointestinal motility were detected. Histopathology was performed in hypothalamus and gastrointestinal tract. Related brain-gut peptides were assayed in serum, hypothalamus and gastrointestinal tract. Illumina Miseq platform was used for 16S rDNA high-throughput sequencing to detect the intestinal flora structure of the caecum of rats.

RESULTS

Traditional Chinese medicine decoction of hawthorn (HT and CHT) regulated the body weight, food intake, gastrointestinal motility and abnormal secretion of brain-gut peptides in rats with HC-DID, and the odor of charred hawthorn also had good curative effect for it. Moreover, the intestinal dysbiosis was induced by high-calorie diet in rats with dyspepsia, and hawthorn decoction could ease this trend.

CONCLUSION

The above study showed that hawthorn decoction coupled with the odor of charred hawthorn effectively alleviate HC-DID in rats by regulating the "Brain-Gut" axis and gut flora. Odor treatment of hawthorn could be a potential therapeutic approach for HC-DID.

Authors+Show Affiliations

Life Science & Engineering College, South-west Jiao-tong University, Chengdu, 610031, China. Electronic address: 853501568@qq.com.Life Science & Engineering College, South-west Jiao-tong University, Chengdu, 610031, China. Electronic address: lvm84470@gmail.com.Life Science & Engineering College, South-west Jiao-tong University, Chengdu, 610031, China. Electronic address: 18482187946@163.com.Life Science & Engineering College, South-west Jiao-tong University, Chengdu, 610031, China. Electronic address: sjingyin1996@163.com.Life Science & Engineering College, South-west Jiao-tong University, Chengdu, 610031, China. Electronic address: 474632670@qq.com.Life Science & Engineering College, South-west Jiao-tong University, Chengdu, 610031, China. Electronic address: 2232986604@qq.com.Key Laboratory of Traditional Chinese Medicine Processing Technology, State Administration of Traditional Chinese Medicine, Chengdu, 610036, China. Electronic address: shengming101@126.com.Life Science & Engineering College, South-west Jiao-tong University, Chengdu, 610031, China. Electronic address: wwangyidi@126.com.Life Science & Engineering College, South-west Jiao-tong University, Chengdu, 610031, China. Electronic address: wjun1013@126.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31421184

Citation

Wang, Yun, et al. "Research On Mechanism of Charred Hawthorn On Digestive Through Modulating "brain-gut" Axis and Gut Flora." Journal of Ethnopharmacology, vol. 245, 2019, p. 112166.
Wang Y, Lv M, Wang T, et al. Research on mechanism of charred hawthorn on digestive through modulating "brain-gut" axis and gut flora. J Ethnopharmacol. 2019;245:112166.
Wang, Y., Lv, M., Wang, T., Sun, J., Wang, Y., Xia, M., ... Wan, J. (2019). Research on mechanism of charred hawthorn on digestive through modulating "brain-gut" axis and gut flora. Journal of Ethnopharmacology, 245, p. 112166. doi:10.1016/j.jep.2019.112166.
Wang Y, et al. Research On Mechanism of Charred Hawthorn On Digestive Through Modulating "brain-gut" Axis and Gut Flora. J Ethnopharmacol. 2019 Aug 14;245:112166. PubMed PMID: 31421184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Research on mechanism of charred hawthorn on digestive through modulating "brain-gut" axis and gut flora. AU - Wang,Yun, AU - Lv,Min, AU - Wang,Ting, AU - Sun,Jingying, AU - Wang,Yuxia, AU - Xia,Manqiong, AU - Jiang,Yun, AU - Zhou,Xia, AU - Wan,Jun, Y1 - 2019/08/14/ PY - 2019/04/06/received PY - 2019/07/27/revised PY - 2019/08/14/accepted PY - 2019/8/20/pubmed PY - 2019/8/20/medline PY - 2019/8/18/entrez KW - Bi-directional brain-gut interactions KW - Gut flora KW - Hawthorn decoction KW - High-calorie-diet-induced dyspepsia KW - Odor treatment SP - 112166 EP - 112166 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 245 N2 - ETHNOPHARMACOLOGICAL RELEVANCE: Hawthorn is a traditional Chinese medicine for high-calorie-diet-induced dyspepsia (HC-DID) for thousands of years old. Based on traditional Chinese medicine (TCM) theory and clinical and non-clinical trials, its stir-frying processed product, charred hawthorn, possesses better effect. At present, most research mainly focuses on chemical constituents of hawthorn before and after stir-frying process, but there is no relevant action-mechanism study about fragrant odor promoting HC-DID during the stir-frying process of the hawthorn. AIM OF THE STUDY: The purpose of the present study is to research on mechanism of hawthorn decoction coupled with odor of charred hawthorn on digestive in rats with HC-DID. MATERIALS AND METHODS: The SPF Kunming (KM) mice and Sprague Dawley (SD) rats were randomly divided into 7 groups: control group, model group, cisapride group, hawthorn group (HT), charred hawthorn group (CHT), odor of charred hawthorn (OCHT), CHT + OCHT group. The rats were modeled as HC-DID, whose treatment by intragastric administration and odor administration. Obvious symptoms of HC-DID were observed. Gastrointestinal motility were detected. Histopathology was performed in hypothalamus and gastrointestinal tract. Related brain-gut peptides were assayed in serum, hypothalamus and gastrointestinal tract. Illumina Miseq platform was used for 16S rDNA high-throughput sequencing to detect the intestinal flora structure of the caecum of rats. RESULTS: Traditional Chinese medicine decoction of hawthorn (HT and CHT) regulated the body weight, food intake, gastrointestinal motility and abnormal secretion of brain-gut peptides in rats with HC-DID, and the odor of charred hawthorn also had good curative effect for it. Moreover, the intestinal dysbiosis was induced by high-calorie diet in rats with dyspepsia, and hawthorn decoction could ease this trend. CONCLUSION: The above study showed that hawthorn decoction coupled with the odor of charred hawthorn effectively alleviate HC-DID in rats by regulating the "Brain-Gut" axis and gut flora. Odor treatment of hawthorn could be a potential therapeutic approach for HC-DID. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/31421184/Research_on_mechanism_of_charred_hawthorn_on_digestive_through_modulating_"brain-gut"_axis_and_gut_flora L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(19)31360-1 DB - PRIME DP - Unbound Medicine ER -