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Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer: A case report.
World J Clin Cases 2019; 7(15):2065-2074WJ

Abstract

BACKGROUND

We present the case of a 72-year-old female patient with gallbladder cancer (GBC) who developed in situ recurrence and liver metastases 9 mo after irreversible electroporation ablation and oral tegafur (a fluoropyrimidine derivative) chemotherapy, which failed to control the progression of the disease. The patient further developed metastases in the lymph nodes around the head of the pancreas. The patient had severe anemia, requiring weekly blood transfusions. The gallbladder tumor invaded the descending part of the duodenum, causing intestinal leakage and hepatic colonic adhesion.

CASE SUMMARY

The patient refused other treatments and began daily hydrogen inhalation therapy. After 1 mo of treatment, the gallbladder and liver tumors continued to progress, and intestinal obstruction occurred. After continuous hydrogen therapy and symptomatic treatments including gastrointestinal decompression and intravenous nutrition support, the intestinal obstruction was gradually relieved. Three months after hydrogen therapy, the metastases in the abdominal cavity gradually reduced in size, her anemia and hypoalbuminemia were corrected, lymphocyte and tumor marker levels returned to normal, and the patient was able to resume normal life.

CONCLUSION

This is the first report of an efficacy and safety study about hydrogen therapy in patient with metastatic GBC and a critical general condition, who has remained stable for more than 4 months.

Authors+Show Affiliations

Central Laboratory, Fuda Cancer Hospital of Jinan University, Guangzhou 510665, Guangdong Province, China.Central Laboratory, Fuda Cancer Hospital of Jinan University, Guangzhou 510665, Guangdong Province, China.Intervention Department of Shenzhen Second People's Hospital, Shenzhen 518035, Guangdong Province, China.Central Laboratory, Fuda Cancer Hospital of Jinan University, Guangzhou 510665, Guangdong Province, China.Central Laboratory, Fuda Cancer Hospital of Jinan University, Guangzhou 510665, Guangdong Province, China.Central Laboratory, Fuda Cancer Hospital of Jinan University, Guangzhou 510665, Guangdong Province, China.Central Laboratory, Fuda Cancer Hospital of Jinan University, Guangzhou 510665, Guangdong Province, China. xukc@vip.163.com.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

31423439

Citation

Chen, Ji-Bing, et al. "Hydrogen Gas Therapy Induced Shrinkage of Metastatic Gallbladder Cancer: a Case Report." World Journal of Clinical Cases, vol. 7, no. 15, 2019, pp. 2065-2074.
Chen JB, Pan ZB, Du DM, et al. Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer: A case report. World J Clin Cases. 2019;7(15):2065-2074.
Chen, J. B., Pan, Z. B., Du, D. M., Qian, W., Ma, Y. Y., Mu, F., & Xu, K. C. (2019). Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer: A case report. World Journal of Clinical Cases, 7(15), pp. 2065-2074. doi:10.12998/wjcc.v7.i15.2065.
Chen JB, et al. Hydrogen Gas Therapy Induced Shrinkage of Metastatic Gallbladder Cancer: a Case Report. World J Clin Cases. 2019 Aug 6;7(15):2065-2074. PubMed PMID: 31423439.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer: A case report. AU - Chen,Ji-Bing, AU - Pan,Zhong-Bao, AU - Du,Duan-Ming, AU - Qian,Wei, AU - Ma,Yang-Yang, AU - Mu,Feng, AU - Xu,Ke-Cheng, PY - 2019/03/02/received PY - 2019/06/17/revised PY - 2019/06/26/accepted PY - 2019/8/20/entrez PY - 2019/8/20/pubmed PY - 2019/8/20/medline KW - Case report KW - Hydrogen gas KW - Metastatic gallbladder cancer SP - 2065 EP - 2074 JF - World journal of clinical cases JO - World J Clin Cases VL - 7 IS - 15 N2 - BACKGROUND: We present the case of a 72-year-old female patient with gallbladder cancer (GBC) who developed in situ recurrence and liver metastases 9 mo after irreversible electroporation ablation and oral tegafur (a fluoropyrimidine derivative) chemotherapy, which failed to control the progression of the disease. The patient further developed metastases in the lymph nodes around the head of the pancreas. The patient had severe anemia, requiring weekly blood transfusions. The gallbladder tumor invaded the descending part of the duodenum, causing intestinal leakage and hepatic colonic adhesion. CASE SUMMARY: The patient refused other treatments and began daily hydrogen inhalation therapy. After 1 mo of treatment, the gallbladder and liver tumors continued to progress, and intestinal obstruction occurred. After continuous hydrogen therapy and symptomatic treatments including gastrointestinal decompression and intravenous nutrition support, the intestinal obstruction was gradually relieved. Three months after hydrogen therapy, the metastases in the abdominal cavity gradually reduced in size, her anemia and hypoalbuminemia were corrected, lymphocyte and tumor marker levels returned to normal, and the patient was able to resume normal life. CONCLUSION: This is the first report of an efficacy and safety study about hydrogen therapy in patient with metastatic GBC and a critical general condition, who has remained stable for more than 4 months. SN - 2307-8960 UR - https://www.unboundmedicine.com/medline/citation/31423439/Hydrogen_gas_therapy_induced_shrinkage_of_metastatic_gallbladder_cancer:_A_case_report L2 - http://www.wjgnet.com/2307-8960/full/v7/i15/2065.htm DB - PRIME DP - Unbound Medicine ER -