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Eschar and IgM ELISA in the diagnosis of scrub typhus.
Indian J Med Microbiol 2019 Jan-Mar; 37(1):113-115IJ

Abstract

Scrub typhus is one of the leading causes of acute febrile illness in India. This study aimed to determine the best diagnostic tool for the identification of scrub typhus and study the possible association between diagnostics and clinical characteristics. Patients with fever of ≤15 days admitted to the hospital satisfying the case definition of 47 kDa quantitative polymerase chain reaction (qPCR) positivity OR scrub typhus IgM ELISA positivity along with the presence of eschar OR Scrub typhus IgM ELISA positivity along with defervescence of fever within 72 h of initiation of specific therapy were recruited. Of the 116 patients satisfying the case definition, 47 kDa qPCR was positive in 43 (37%) patients, whereas IgM ELISA was positive in 104 (90%) patients and eschar was seen in 59 (51%) patients. The median duration of fever was 7.5 days (interquartile range 6-10 days). Multiorgan dysfunction syndrome (MODS) was described in 44 (37.9%) patients. Two patients (1.8%) succumbed to the illness. Presence of eschar and IgM ELISA positivity were detected in 106 (91%) cases. Scrub typhus, even with MODS, has low mortality because of immediate institution of specific therapy due to physician awareness. The presence of eschar and IgM ELISA positivity can be used to detect a majority of cases of scrub typhus.

Authors+Show Affiliations

Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.Department of Emergency Medicine, Christian Medical College, Vellore, Tamil Nadu, India.Department of General Medicine, Christian Medical College, Vellore, Tamil Nadu, India.Department of Child Health, Christian Medical College, Vellore, Tamil Nadu, India.Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, India.Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31424021

Citation

Perumalla, Susmitha Karunasree, et al. "Eschar and IgM ELISA in the Diagnosis of Scrub Typhus." Indian Journal of Medical Microbiology, vol. 37, no. 1, 2019, pp. 113-115.
Perumalla SK, Paul S, Abhilash KPP, et al. Eschar and IgM ELISA in the diagnosis of scrub typhus. Indian J Med Microbiol. 2019;37(1):113-115.
Perumalla, S. K., Paul, S., Abhilash, K. P. P., Gunasekaran, K., Rose, W., Mahasampath, G., & Jude, P. J. (2019). Eschar and IgM ELISA in the diagnosis of scrub typhus. Indian Journal of Medical Microbiology, 37(1), pp. 113-115. doi:10.4103/0255-0857.264495.
Perumalla SK, et al. Eschar and IgM ELISA in the Diagnosis of Scrub Typhus. Indian J Med Microbiol. 2019;37(1):113-115. PubMed PMID: 31424021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eschar and IgM ELISA in the diagnosis of scrub typhus. AU - Perumalla,Susmitha Karunasree, AU - Paul,Sania, AU - Abhilash,K P P, AU - Gunasekaran,Karthik, AU - Rose,Winsley, AU - Mahasampath,Gowri, AU - Jude,Prakash John, PY - 2019/8/20/entrez PY - 2019/8/20/pubmed PY - 2019/8/20/medline KW - Acute febrile illness KW - eschar KW - mortality KW - multiorgan dysfunction syndrome KW - scrub typhus SP - 113 EP - 115 JF - Indian journal of medical microbiology JO - Indian J Med Microbiol VL - 37 IS - 1 N2 - Scrub typhus is one of the leading causes of acute febrile illness in India. This study aimed to determine the best diagnostic tool for the identification of scrub typhus and study the possible association between diagnostics and clinical characteristics. Patients with fever of ≤15 days admitted to the hospital satisfying the case definition of 47 kDa quantitative polymerase chain reaction (qPCR) positivity OR scrub typhus IgM ELISA positivity along with the presence of eschar OR Scrub typhus IgM ELISA positivity along with defervescence of fever within 72 h of initiation of specific therapy were recruited. Of the 116 patients satisfying the case definition, 47 kDa qPCR was positive in 43 (37%) patients, whereas IgM ELISA was positive in 104 (90%) patients and eschar was seen in 59 (51%) patients. The median duration of fever was 7.5 days (interquartile range 6-10 days). Multiorgan dysfunction syndrome (MODS) was described in 44 (37.9%) patients. Two patients (1.8%) succumbed to the illness. Presence of eschar and IgM ELISA positivity were detected in 106 (91%) cases. Scrub typhus, even with MODS, has low mortality because of immediate institution of specific therapy due to physician awareness. The presence of eschar and IgM ELISA positivity can be used to detect a majority of cases of scrub typhus. SN - 1998-3646 UR - https://www.unboundmedicine.com/medline/citation/31424021/Eschar_and_IgM_ELISA_in_the_diagnosis_of_scrub_typhus L2 - http://www.ijmm.org/article.asp?issn=0255-0857;year=2019;volume=37;issue=1;spage=113;epage=115;aulast=Perumalla DB - PRIME DP - Unbound Medicine ER -