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Sputum examination in the diagnosis of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome.
Arch Pathol Lab Med. 1988 Dec; 112(12):1229-32.AP

Abstract

To examine the role of sputum examination in the diagnosis of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome (AIDS), we conducted a prospective study of 30 patients with AIDS or suspected AIDS. Sputum was obtained just prior to bronchoscopy by spontaneous cough (20 patients) or by induction with a saline nebulizer (ten patients). Pneumocystis carinii was diagnosed by bronchoalveolar lavage in 13 of the 30 patients; two of these patients had P carinii organisms identified in sputum specimens (sensitivity of sputum, 15.3%; negative predictive value, 60.7%). A cost-analysis study demonstrated that sputum examination is not cost effective when the sensitivity is below 24%. We conclude that P carinii can be diagnosed from expectorated sputum in patients with AIDS, but, because of the test's low sensitivity, it cannot be recommended in the routine evaluation of patients with AIDS and pulmonary complaints.

Authors+Show Affiliations

Department of Medicine, Emory University School of Medicine, Atlanta, GA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3142440

Citation

del Rio, C, et al. "Sputum Examination in the Diagnosis of Pneumocystis Carinii Pneumonia in the Acquired Immunodeficiency Syndrome." Archives of Pathology & Laboratory Medicine, vol. 112, no. 12, 1988, pp. 1229-32.
del Rio C, Guarner J, Honig EG, et al. Sputum examination in the diagnosis of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Arch Pathol Lab Med. 1988;112(12):1229-32.
del Rio, C., Guarner, J., Honig, E. G., & Slade, B. A. (1988). Sputum examination in the diagnosis of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. Archives of Pathology & Laboratory Medicine, 112(12), 1229-32.
del Rio C, et al. Sputum Examination in the Diagnosis of Pneumocystis Carinii Pneumonia in the Acquired Immunodeficiency Syndrome. Arch Pathol Lab Med. 1988;112(12):1229-32. PubMed PMID: 3142440.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sputum examination in the diagnosis of Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome. AU - del Rio,C, AU - Guarner,J, AU - Honig,E G, AU - Slade,B A, PY - 1988/12/1/pubmed PY - 1988/12/1/medline PY - 1988/12/1/entrez SP - 1229 EP - 32 JF - Archives of pathology & laboratory medicine JO - Arch Pathol Lab Med VL - 112 IS - 12 N2 - To examine the role of sputum examination in the diagnosis of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome (AIDS), we conducted a prospective study of 30 patients with AIDS or suspected AIDS. Sputum was obtained just prior to bronchoscopy by spontaneous cough (20 patients) or by induction with a saline nebulizer (ten patients). Pneumocystis carinii was diagnosed by bronchoalveolar lavage in 13 of the 30 patients; two of these patients had P carinii organisms identified in sputum specimens (sensitivity of sputum, 15.3%; negative predictive value, 60.7%). A cost-analysis study demonstrated that sputum examination is not cost effective when the sensitivity is below 24%. We conclude that P carinii can be diagnosed from expectorated sputum in patients with AIDS, but, because of the test's low sensitivity, it cannot be recommended in the routine evaluation of patients with AIDS and pulmonary complaints. SN - 0003-9985 UR - https://www.unboundmedicine.com/medline/citation/3142440/Sputum_examination_in_the_diagnosis_of_Pneumocystis_carinii_pneumonia_in_the_acquired_immunodeficiency_syndrome_ L2 - https://medlineplus.gov/hivaids.html DB - PRIME DP - Unbound Medicine ER -