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Oral Pain in the Cancer Patient.
J Natl Cancer Inst Monogr 2019; 2019(53)JN

Abstract

Oral pain due to cancer and associated treatments is common. The prevalence and severity of oral cancer is high. Painful oral mucositis develops in head and neck cancer patients following surgery and associated radiation therapy and/or chemotherapy. In addition, oral pain, including pain from mucositis, occurs in patients receiving chemotherapy for cancers of the hematopoietic system and cancers at other anatomic sites. Despite pain management practices that include high-dose opioid analgesics, patients rarely obtain relief from either head and neck cancer pain or mucositis pain. Because oral pain in cancer patients is likely due to both nociceptive and neuropathic mechanisms, effective management of pain requires treatments for both processes. As knowledge of the pathophysiology of oral pain in cancer patients increases, new approaches for the prevention and management are anticipated. This article focuses on the emerging evidence that supports the molecular mechanisms and the unique oral micro-neuroanatomy that in combination produce the severe oral pain experienced by cancer patients. In addition, this article summarizes the current state of clinical management of oral mucositis pain.

Authors+Show Affiliations

Department of Surgery, City of Hope, Duarte, CA. Department of Surgery, Cedars-Sinai Health System, Los Angeles, CA. Seattle Cancer Care Alliance, Seattle, WA.Department of Physiological Nursing, University of California San Francisco, San Francisco, CA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31425595

Citation

Epstein, Joel B., and Christine Miaskowski. "Oral Pain in the Cancer Patient." Journal of the National Cancer Institute. Monographs, vol. 2019, no. 53, 2019.
Epstein JB, Miaskowski C. Oral Pain in the Cancer Patient. J Natl Cancer Inst Monographs. 2019;2019(53).
Epstein, J. B., & Miaskowski, C. (2019). Oral Pain in the Cancer Patient. Journal of the National Cancer Institute. Monographs, 2019(53), doi:10.1093/jncimonographs/lgz003.
Epstein JB, Miaskowski C. Oral Pain in the Cancer Patient. J Natl Cancer Inst Monographs. 2019 Aug 1;2019(53) PubMed PMID: 31425595.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oral Pain in the Cancer Patient. AU - Epstein,Joel B, AU - Miaskowski,Christine, PY - 2019/01/11/received PY - 2019/02/07/revised PY - 2019/04/01/accepted PY - 2019/8/20/entrez PY - 2019/8/20/pubmed PY - 2019/8/20/medline JF - Journal of the National Cancer Institute. Monographs JO - J. Natl. Cancer Inst. Monographs VL - 2019 IS - 53 N2 - Oral pain due to cancer and associated treatments is common. The prevalence and severity of oral cancer is high. Painful oral mucositis develops in head and neck cancer patients following surgery and associated radiation therapy and/or chemotherapy. In addition, oral pain, including pain from mucositis, occurs in patients receiving chemotherapy for cancers of the hematopoietic system and cancers at other anatomic sites. Despite pain management practices that include high-dose opioid analgesics, patients rarely obtain relief from either head and neck cancer pain or mucositis pain. Because oral pain in cancer patients is likely due to both nociceptive and neuropathic mechanisms, effective management of pain requires treatments for both processes. As knowledge of the pathophysiology of oral pain in cancer patients increases, new approaches for the prevention and management are anticipated. This article focuses on the emerging evidence that supports the molecular mechanisms and the unique oral micro-neuroanatomy that in combination produce the severe oral pain experienced by cancer patients. In addition, this article summarizes the current state of clinical management of oral mucositis pain. SN - 1745-6614 UR - https://www.unboundmedicine.com/medline/citation/31425595/Oral_Pain_in_the_Cancer_Patient L2 - https://academic.oup.com/jncimono/article-lookup/doi/10.1093/jncimonographs/lgz003 DB - PRIME DP - Unbound Medicine ER -