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Chronic Systemic Symptoms in Head and Neck Cancer Patients.
J Natl Cancer Inst Monogr 2019; 2019(53)JN

Abstract

The systemic effects and manifestations of disease and treatment have been of interest for millennium. Until recently, basic and clinical research is just now reaching a watershed. Systemic symptoms usually do not occur in isolation but rather in clusters; however, much of the cutting-edge research pertaining to the etiology, mechanism, manifestations, and moderators of systemic symptoms in humans has been directed at individual symptoms, thus creating silos of knowledge. Breaching these silos and bridging the knowledge from disparate arenas of investigation to build a comprehensive depiction of acute and chronic systemic symptoms has been a challenge. In addition, much of the recent work in systemic symptoms has been conducted in the setting of nonmalignant disease. The degree to which the findings from other chronic disease processes can be translated into the oncologic realm is unknown. This article will explore inflammation as a major contributing factor to systemic symptoms and sickness behavior, discuss the most common manifestations in cancer survivors, and, where available, discuss specific data pertaining to head and neck cancer survivors.

Authors+Show Affiliations

Department of Medicine and Division of Hematology-Oncology, Vanderbilt University Medical Center, Nashville, TN.Department of Medicine and Division of Hematology-Oncology, Vanderbilt University Medical Center, Nashville, TN.Vanderbilt University School of Medicine, Nashville, TN.William F. Connell School of Nursing, Boston College, Boston, MA.School of Nursing, University of Pennsylvania, Philadelphia PA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31425597

Citation

Murphy, Barbara A., et al. "Chronic Systemic Symptoms in Head and Neck Cancer Patients." Journal of the National Cancer Institute. Monographs, vol. 2019, no. 53, 2019.
Murphy BA, Wulff-Burchfield E, Ghiam M, et al. Chronic Systemic Symptoms in Head and Neck Cancer Patients. J Natl Cancer Inst Monographs. 2019;2019(53).
Murphy, B. A., Wulff-Burchfield, E., Ghiam, M., Bond, S. M., & Deng, J. (2019). Chronic Systemic Symptoms in Head and Neck Cancer Patients. Journal of the National Cancer Institute. Monographs, 2019(53), doi:10.1093/jncimonographs/lgz004.
Murphy BA, et al. Chronic Systemic Symptoms in Head and Neck Cancer Patients. J Natl Cancer Inst Monographs. 2019 Aug 1;2019(53) PubMed PMID: 31425597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic Systemic Symptoms in Head and Neck Cancer Patients. AU - Murphy,Barbara A, AU - Wulff-Burchfield,Elizabeth, AU - Ghiam,Michael, AU - Bond,Stewart M, AU - Deng,Jie, PY - 2018/09/25/received PY - 2019/02/22/revised PY - 2019/04/01/accepted PY - 2019/8/20/entrez PY - 2019/8/20/pubmed PY - 2019/8/20/medline JF - Journal of the National Cancer Institute. Monographs JO - J. Natl. Cancer Inst. Monographs VL - 2019 IS - 53 N2 - The systemic effects and manifestations of disease and treatment have been of interest for millennium. Until recently, basic and clinical research is just now reaching a watershed. Systemic symptoms usually do not occur in isolation but rather in clusters; however, much of the cutting-edge research pertaining to the etiology, mechanism, manifestations, and moderators of systemic symptoms in humans has been directed at individual symptoms, thus creating silos of knowledge. Breaching these silos and bridging the knowledge from disparate arenas of investigation to build a comprehensive depiction of acute and chronic systemic symptoms has been a challenge. In addition, much of the recent work in systemic symptoms has been conducted in the setting of nonmalignant disease. The degree to which the findings from other chronic disease processes can be translated into the oncologic realm is unknown. This article will explore inflammation as a major contributing factor to systemic symptoms and sickness behavior, discuss the most common manifestations in cancer survivors, and, where available, discuss specific data pertaining to head and neck cancer survivors. SN - 1745-6614 UR - https://www.unboundmedicine.com/medline/citation/31425597/Chronic_Systemic_Symptoms_in_Head_and_Neck_Cancer_Patients L2 - https://academic.oup.com/jncimono/article-lookup/doi/10.1093/jncimonographs/lgz004 DB - PRIME DP - Unbound Medicine ER -