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Efficacy and safety of cinnamon in type 2 diabetes mellitus and pre-diabetes patients: A meta-analysis and meta-regression.
Diabetes Res Clin Pract 2019; 156:107815DR

Abstract

INTRODUCTION

Cinnamon has been used as a dietary component and in the management of diabetes mellitus. This study systematically reviewed and synthesized evidence on the efficacy of cinnamon for the treatment of type 2 diabetes mellitus (T2DM) and pre-diabetes patients.

METHODS

Databases of Web of Sciences, the Cochrane library, PubMed, CINAHL and SCOPUS were searched. Stata version 13 (College Station, Texas 77845 USA) and RevMan var. 5.3 software were used for meta-analysis. Heterogeneity was assessed using Chi-square and I2 tests.

RESULTS

Sixteen randomized controlled studies were included in the meta-analysis. Cinnamon significantly reduced fasting blood glucose (FBG) and homeostatic model assessment for insulin resistance (HOMA-IR) level compared to placebo with weighted mean difference (WMD) of -0.545 (95% CI: -0.910, -0.18) mmol/L, I2 = 83.6% and -0.714(-1.388, -0.04), I2 = 84.4% respectively. There was no significant change in weighted mean difference of glycosylated hemoglobin A1C (HbA1c) % and lipid profiles (mmol/L). Meta-regression did not show any factor significantly affecting the treatment response.

CONCLUSION

Cinnamon reduced FBG and HOMA-IR, level in T2DM and pre-diabetes patients compared to placebo. High heterogeneity observed among included studies warrants further clinical trials after standardization of cinnamon formulation.

Authors+Show Affiliations

Pharm-BioTechnology and Traditional Medicine Center of Excellence (PHARMBIOTRAC), Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda; Faculty of Medicine, College of Medicine and Health Sciences, Hawassa University, P. O. Box 1560, Hawassa, Ethiopia. Electronic address: dserawit@std.must.ac.ug.Faculty of Medicine, College of Medicine and Health Sciences, Hawassa University, P. O. Box 1560, Hawassa, Ethiopia.Faculty of Medicine, College of Medicine and Health Sciences, Hawassa University, P. O. Box 1560, Hawassa, Ethiopia.Pharm-BioTechnology and Traditional Medicine Center of Excellence (PHARMBIOTRAC), Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda; School of Nursing and Midwifery, College of Medicine and Health Sciences, University of Rwanda, University Avenue, P.O. Box 56, Butare, Rwanda. Electronic address: ntuyiringire@std.must.ac.ug.Pharm-BioTechnology and Traditional Medicine Center of Excellence (PHARMBIOTRAC), Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda; Department of Innovation, Technology Transfer & Commercialization, National Institute for Medical Research, Barack Obama Drive, P.O. Box 9653, 2448 Dar Es Salaam, Tanzania. Electronic address: epeter@std.must.ac.ug.Traditional and Modern Drug Research Directorate, Ethiopian Public Health Institute, Ethiopia.Pharm-BioTechnology and Traditional Medicine Center of Excellence (PHARMBIOTRAC), Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda. Electronic address: tolocas@must.ac.ug.Pharm-BioTechnology and Traditional Medicine Center of Excellence (PHARMBIOTRAC), Mbarara University of Science and Technology, P.O. Box 1410, Mbarara, Uganda. Electronic address: pogwang@must.ac.ug.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31425768

Citation

Deyno, Serawit, et al. "Efficacy and Safety of Cinnamon in Type 2 Diabetes Mellitus and Pre-diabetes Patients: a Meta-analysis and Meta-regression." Diabetes Research and Clinical Practice, vol. 156, 2019, p. 107815.
Deyno S, Eneyew K, Seyfe S, et al. Efficacy and safety of cinnamon in type 2 diabetes mellitus and pre-diabetes patients: A meta-analysis and meta-regression. Diabetes Res Clin Pract. 2019;156:107815.
Deyno, S., Eneyew, K., Seyfe, S., Tuyiringire, N., Peter, E. L., Muluye, R. A., ... Ogwang, P. E. (2019). Efficacy and safety of cinnamon in type 2 diabetes mellitus and pre-diabetes patients: A meta-analysis and meta-regression. Diabetes Research and Clinical Practice, 156, p. 107815. doi:10.1016/j.diabres.2019.107815.
Deyno S, et al. Efficacy and Safety of Cinnamon in Type 2 Diabetes Mellitus and Pre-diabetes Patients: a Meta-analysis and Meta-regression. Diabetes Res Clin Pract. 2019 Aug 16;156:107815. PubMed PMID: 31425768.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and safety of cinnamon in type 2 diabetes mellitus and pre-diabetes patients: A meta-analysis and meta-regression. AU - Deyno,Serawit, AU - Eneyew,Kassahun, AU - Seyfe,Sisay, AU - Tuyiringire,Naasson, AU - Peter,Emanuel L, AU - Muluye,Rekik Ashebir, AU - Tolo,Casim Umba, AU - Ogwang,Patrick Engeu, Y1 - 2019/08/16/ PY - 2019/05/24/received PY - 2019/08/08/revised PY - 2019/08/12/accepted PY - 2019/8/20/pubmed PY - 2019/8/20/medline PY - 2019/8/20/entrez KW - Blood sugar level KW - Diabetes mellitus KW - Efficacy KW - Herbal therapy KW - Systematic review SP - 107815 EP - 107815 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 156 N2 - INTRODUCTION: Cinnamon has been used as a dietary component and in the management of diabetes mellitus. This study systematically reviewed and synthesized evidence on the efficacy of cinnamon for the treatment of type 2 diabetes mellitus (T2DM) and pre-diabetes patients. METHODS: Databases of Web of Sciences, the Cochrane library, PubMed, CINAHL and SCOPUS were searched. Stata version 13 (College Station, Texas 77845 USA) and RevMan var. 5.3 software were used for meta-analysis. Heterogeneity was assessed using Chi-square and I2 tests. RESULTS: Sixteen randomized controlled studies were included in the meta-analysis. Cinnamon significantly reduced fasting blood glucose (FBG) and homeostatic model assessment for insulin resistance (HOMA-IR) level compared to placebo with weighted mean difference (WMD) of -0.545 (95% CI: -0.910, -0.18) mmol/L, I2 = 83.6% and -0.714(-1.388, -0.04), I2 = 84.4% respectively. There was no significant change in weighted mean difference of glycosylated hemoglobin A1C (HbA1c) % and lipid profiles (mmol/L). Meta-regression did not show any factor significantly affecting the treatment response. CONCLUSION: Cinnamon reduced FBG and HOMA-IR, level in T2DM and pre-diabetes patients compared to placebo. High heterogeneity observed among included studies warrants further clinical trials after standardization of cinnamon formulation. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/31425768/Efficacy_and_safety_of_Cinnamon_in_Type_2_Diabetes_Mellitus_and_Pre-diabetes_patients:_A_Meta-analysis_and_Meta-regression L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(19)30706-5 DB - PRIME DP - Unbound Medicine ER -