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Telomere length measurement in tumor and non-tumor cells as a valuable prognostic for tumor progression.
Cancer Genet 2019; 238:50-61CG

Abstract

Telomere shortening has been supposed to be implicated in both aging and various human diseases especially carcinogenesis process. This phenomenon can lead to a chromosomal instability, contributing to a cell immortalization and tumor induction. In our study, we analyzed the role of telomere shortening in cancer progression, in Tunisian patients with digestive cancer. We measured the absolute telomere length in tumoral vs healthy adjacent tissues of each patient by using a q-RT PCR method and we investigated the relationship between telomere length and various sociodemographic and clinical parameters such as age, sex, tumor stage. In this pathological situation, we observed that, starting from 60 years of age, the telomere length increases in healthy mucosa and that in both healthy and cancer tissues, patients under 60 years have shorter telomeres, suggesting the telomere lengthening becomes more active with age. Finally, a positive correlation between normal and cancer tissues in both non-metastatic and metastatic stages, indicates telomere length in cancer tissue depends essentially on tumor stages. Our data allow us to suggest that telomere length depends on sex and age in healthy tissue while shortening and lengthening fluctuates considerably according to the tumor stage.

Authors+Show Affiliations

University of Tunis El Manar, Faculty of Sciences of Tunis, LR05ES05 Laboratory of Genetics, Immunology and Human Pathology, 2092 Tunis, Tunisia.University of Tunis El Manar, Faculty of Sciences of Tunis, LR05ES05 Laboratory of Genetics, Immunology and Human Pathology, 2092 Tunis, Tunisia; University of Tunis El Manar, Higher Institute of Nursing Sciences of Tunis, 1007 Tunis, Tunisia.University of Tuscia, Department of Ecological and Biological Sciences, Viterbo, Italy.Bioinformatics Facility European Brain Research Institute (EBRI) "Rita Levi-Montalcini", Viale Regina Elena 295, 00161 Roma, Italy; Institute of Translational Pharmacology National Research Council (CNR), Roma, Italy.University of Tuscia, Department of Ecological and Biological Sciences, Viterbo, Italy.University of Tuscia, Department of Ecological and Biological Sciences, Viterbo, Italy.University of Tunis El Manar, Faculty of Medicine of Tunis, Laboratory of Physiology, 1007 Tunis, Tunisia; La Rabta Hospital, Gastroenterology Department A, 1007 Tunis, Tunisia.University of Tuscia, Department of Ecological and Biological Sciences, Viterbo, Italy.University of Tunis El Manar, Faculty of Sciences of Tunis, LR05ES05 Laboratory of Genetics, Immunology and Human Pathology, 2092 Tunis, Tunisia.University of Tuscia, Department of Ecological and Biological Sciences, Viterbo, Italy. Electronic address: bongiorni@unitus.it.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31425926

Citation

Mehrez, Fatma, et al. "Telomere Length Measurement in Tumor and Non-tumor Cells as a Valuable Prognostic for Tumor Progression." Cancer Genetics, vol. 238, 2019, pp. 50-61.
Mehrez F, Bougatef K, Monache ED, et al. Telomere length measurement in tumor and non-tumor cells as a valuable prognostic for tumor progression. Cancer Genet. 2019;238:50-61.
Mehrez, F., Bougatef, K., Monache, E. D., Arisi, I., Proietti-De-Santis, L., Prantera, G., ... Bongiorni, S. (2019). Telomere length measurement in tumor and non-tumor cells as a valuable prognostic for tumor progression. Cancer Genetics, 238, pp. 50-61. doi:10.1016/j.cancergen.2019.07.007.
Mehrez F, et al. Telomere Length Measurement in Tumor and Non-tumor Cells as a Valuable Prognostic for Tumor Progression. Cancer Genet. 2019 Jul 26;238:50-61. PubMed PMID: 31425926.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Telomere length measurement in tumor and non-tumor cells as a valuable prognostic for tumor progression. AU - Mehrez,Fatma, AU - Bougatef,Karim, AU - Monache,Elisa Delle, AU - Arisi,Ivan, AU - Proietti-De-Santis,Luca, AU - Prantera,Giorgio, AU - Zouiten,Lilia, AU - Caputo,Manuela, AU - Ben Ammar Elgaaied,Amel, AU - Bongiorni,Silvia, Y1 - 2019/07/26/ PY - 2019/05/02/received PY - 2019/07/09/revised PY - 2019/07/22/accepted PY - 2019/8/20/entrez PY - 2019/8/20/pubmed PY - 2019/8/20/medline KW - Colorectal cancer KW - Digestive cancer KW - Quantitative PCR method KW - Telomere behavior KW - Telomere length KW - Telomere measurement SP - 50 EP - 61 JF - Cancer genetics JO - Cancer Genet VL - 238 N2 - Telomere shortening has been supposed to be implicated in both aging and various human diseases especially carcinogenesis process. This phenomenon can lead to a chromosomal instability, contributing to a cell immortalization and tumor induction. In our study, we analyzed the role of telomere shortening in cancer progression, in Tunisian patients with digestive cancer. We measured the absolute telomere length in tumoral vs healthy adjacent tissues of each patient by using a q-RT PCR method and we investigated the relationship between telomere length and various sociodemographic and clinical parameters such as age, sex, tumor stage. In this pathological situation, we observed that, starting from 60 years of age, the telomere length increases in healthy mucosa and that in both healthy and cancer tissues, patients under 60 years have shorter telomeres, suggesting the telomere lengthening becomes more active with age. Finally, a positive correlation between normal and cancer tissues in both non-metastatic and metastatic stages, indicates telomere length in cancer tissue depends essentially on tumor stages. Our data allow us to suggest that telomere length depends on sex and age in healthy tissue while shortening and lengthening fluctuates considerably according to the tumor stage. SN - 2210-7762 UR - https://www.unboundmedicine.com/medline/citation/31425926/Telomere_length_measurement_in_tumor_and_non-tumor_cells_as_a_valuable_prognostic_for_tumor_progression L2 - https://linkinghub.elsevier.com/retrieve/pii/S2210-7762(19)30250-9 DB - PRIME DP - Unbound Medicine ER -