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Urinary metabolites of organophosphate esters and implications for exposure pathways in adolescents from Eastern China.
Sci Total Environ 2019; 695:133894ST

Abstract

Ten urinary biomarkers of organophosphate esters (OPEs) from six parent OPEs were analyzed in urine from adolescents students in Eastern China. Bis (1,3-dichloro-2-propyl) phosphate, urinary biomarker of tris (1,3-dichloro-2-propyl) phosphate (TDCIPP), was detected in all urine samples with the highest residual concentration of 6.2 ng/mL (median). Bis (1-chloro-propyl) hydroxyl-2-propyl phosphate, dibutyl phosphate, biomarkers of tris (1-chloro-2-propyl) phosphate (TCIPP), tri-n-butyl phosphate (TNBP), respectively, and tris (2-chloroethyl) phosphate (TCEP), were also frequently detected with median concentrations of 1.5, 2.6 and 0.3 ng/mL, respectively. Results indicate that exposure to OPEs, in particular to TDCIPP, TNBP, TCIPP and TCEP, was highly prevalent for adolescent students. The exposure pathways of OPEs were then evaluated according to the OPE internal body burdens (IBBs). Three pathways were identified as the main pathways for adolescents exposed to OPEs including dermal absorption, oral intake of food and dust and inhalation.

Authors+Show Affiliations

Key Laboratory of Environment Remediation and Ecological Health, Ministry of Education, College of Natural Resources and Environmental Science, Zhejiang University, Hangzhou, China; Research Institute of Zhejiang University-Taizhou, Zhejiang, China.Key Laboratory of Environment Remediation and Ecological Health, Ministry of Education, College of Natural Resources and Environmental Science, Zhejiang University, Hangzhou, China.Key Laboratory of Environment Remediation and Ecological Health, Ministry of Education, College of Natural Resources and Environmental Science, Zhejiang University, Hangzhou, China.Toxicological Center, University of Antwerp, Wilrijk, Belgium.Key Laboratory of Environment Remediation and Ecological Health, Ministry of Education, College of Natural Resources and Environmental Science, Zhejiang University, Hangzhou, China.Key Laboratory of Environment Remediation and Ecological Health, Ministry of Education, College of Natural Resources and Environmental Science, Zhejiang University, Hangzhou, China. Electronic address: fxyang@zju.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31425989

Citation

Ding, Jinjian, et al. "Urinary Metabolites of Organophosphate Esters and Implications for Exposure Pathways in Adolescents From Eastern China." The Science of the Total Environment, vol. 695, 2019, p. 133894.
Ding J, Deng T, Ye X, et al. Urinary metabolites of organophosphate esters and implications for exposure pathways in adolescents from Eastern China. Sci Total Environ. 2019;695:133894.
Ding, J., Deng, T., Ye, X., Covaci, A., Liu, J., & Yang, F. (2019). Urinary metabolites of organophosphate esters and implications for exposure pathways in adolescents from Eastern China. The Science of the Total Environment, 695, p. 133894. doi:10.1016/j.scitotenv.2019.133894.
Ding J, et al. Urinary Metabolites of Organophosphate Esters and Implications for Exposure Pathways in Adolescents From Eastern China. Sci Total Environ. 2019 Aug 12;695:133894. PubMed PMID: 31425989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Urinary metabolites of organophosphate esters and implications for exposure pathways in adolescents from Eastern China. AU - Ding,Jinjian, AU - Deng,Tongqing, AU - Ye,Xiaoqing, AU - Covaci,Adrian, AU - Liu,Jing, AU - Yang,Fangxing, Y1 - 2019/08/12/ PY - 2019/05/22/received PY - 2019/08/10/revised PY - 2019/08/11/accepted PY - 2019/8/20/pubmed PY - 2019/8/20/medline PY - 2019/8/20/entrez KW - Adolescents KW - Dermal absorption KW - Exposure pathway KW - Oral intake KW - Organophosphate esters KW - Urinary biomarker SP - 133894 EP - 133894 JF - The Science of the total environment JO - Sci. Total Environ. VL - 695 N2 - Ten urinary biomarkers of organophosphate esters (OPEs) from six parent OPEs were analyzed in urine from adolescents students in Eastern China. Bis (1,3-dichloro-2-propyl) phosphate, urinary biomarker of tris (1,3-dichloro-2-propyl) phosphate (TDCIPP), was detected in all urine samples with the highest residual concentration of 6.2 ng/mL (median). Bis (1-chloro-propyl) hydroxyl-2-propyl phosphate, dibutyl phosphate, biomarkers of tris (1-chloro-2-propyl) phosphate (TCIPP), tri-n-butyl phosphate (TNBP), respectively, and tris (2-chloroethyl) phosphate (TCEP), were also frequently detected with median concentrations of 1.5, 2.6 and 0.3 ng/mL, respectively. Results indicate that exposure to OPEs, in particular to TDCIPP, TNBP, TCIPP and TCEP, was highly prevalent for adolescent students. The exposure pathways of OPEs were then evaluated according to the OPE internal body burdens (IBBs). Three pathways were identified as the main pathways for adolescents exposed to OPEs including dermal absorption, oral intake of food and dust and inhalation. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/31425989/Urinary_metabolites_of_organophosphate_esters_and_implications_for_exposure_pathways_in_adolescents_from_Eastern_China L2 - https://linkinghub.elsevier.com/retrieve/pii/S0048-9697(19)33844-6 DB - PRIME DP - Unbound Medicine ER -