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Mast Cells, Neuroinflammation and Pain in Fibromyalgia Syndrome.
Front Cell Neurosci 2019; 13:353FC

Abstract

Fibromyalgia Syndrome (FMS) is a disorder of chronic, generalized muscular pain, accompanied by sleep disturbances, fatigue and cognitive dysfunction. There is no definitive pathogenesis except for altered central pain pathways. We previously reported increased serum levels of the neuropeptides substance P (SP) and its structural analogue hemokinin-1 (HK-1) together with the pro-inflammatory cytokines IL-6 and TNF in FMS patients as compared to sedentary controls. We hypothesize that thalamic mast cells contribute to inflammation and pain, by releasing neuro-sensitizing molecules that include histamine, IL-1β, IL-6 and TNF, as well as calcitonin-gene related peptide (CGRP), HK-1 and SP. These molecules could either stimulate thalamic nociceptive neurons directly, or via stimulation of microglia in the diencephalon. As a result, inhibiting mast cell stimulation could be used as a novel approach for reducing pain and the symptoms of FMS.

Authors+Show Affiliations

Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston, MA, United States. Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, United States. Department of Internal Medicine, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, United States. Department of Psychiatry, Tufts Medical Center, Tufts University School of Medicine, Boston, MA, United States.Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston, MA, United States.Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston, MA, United States. Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, MA, United States. Department of Basic Medical Sciences, College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31427928

Citation

Theoharides, Theoharis C., et al. "Mast Cells, Neuroinflammation and Pain in Fibromyalgia Syndrome." Frontiers in Cellular Neuroscience, vol. 13, 2019, p. 353.
Theoharides TC, Tsilioni I, Bawazeer M. Mast Cells, Neuroinflammation and Pain in Fibromyalgia Syndrome. Front Cell Neurosci. 2019;13:353.
Theoharides, T. C., Tsilioni, I., & Bawazeer, M. (2019). Mast Cells, Neuroinflammation and Pain in Fibromyalgia Syndrome. Frontiers in Cellular Neuroscience, 13, p. 353. doi:10.3389/fncel.2019.00353.
Theoharides TC, Tsilioni I, Bawazeer M. Mast Cells, Neuroinflammation and Pain in Fibromyalgia Syndrome. Front Cell Neurosci. 2019;13:353. PubMed PMID: 31427928.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mast Cells, Neuroinflammation and Pain in Fibromyalgia Syndrome. AU - Theoharides,Theoharis C, AU - Tsilioni,Irene, AU - Bawazeer,Mona, Y1 - 2019/08/02/ PY - 2019/05/20/received PY - 2019/07/16/accepted PY - 2019/8/21/entrez PY - 2019/8/21/pubmed PY - 2019/8/21/medline KW - IL-1 beta KW - IL-6) KW - fibromyalgia syndrome KW - mast cells KW - neuroinflammation KW - pain KW - proinflammatory cytokines (TNF-alpha SP - 353 EP - 353 JF - Frontiers in cellular neuroscience JO - Front Cell Neurosci VL - 13 N2 - Fibromyalgia Syndrome (FMS) is a disorder of chronic, generalized muscular pain, accompanied by sleep disturbances, fatigue and cognitive dysfunction. There is no definitive pathogenesis except for altered central pain pathways. We previously reported increased serum levels of the neuropeptides substance P (SP) and its structural analogue hemokinin-1 (HK-1) together with the pro-inflammatory cytokines IL-6 and TNF in FMS patients as compared to sedentary controls. We hypothesize that thalamic mast cells contribute to inflammation and pain, by releasing neuro-sensitizing molecules that include histamine, IL-1β, IL-6 and TNF, as well as calcitonin-gene related peptide (CGRP), HK-1 and SP. These molecules could either stimulate thalamic nociceptive neurons directly, or via stimulation of microglia in the diencephalon. As a result, inhibiting mast cell stimulation could be used as a novel approach for reducing pain and the symptoms of FMS. SN - 1662-5102 UR - https://www.unboundmedicine.com/medline/citation/31427928/Mast_Cells,_Neuroinflammation_and_Pain_in_Fibromyalgia_Syndrome L2 - https://doi.org/10.3389/fncel.2019.00353 DB - PRIME DP - Unbound Medicine ER -