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Heat Transfer Evaluation During Twin-Screw Wet Granulation in View of Detailed Process Understanding.
AAPS PharmSciTech. 2019 Aug 19; 20(7):291.AP

Abstract

During the last decade, the pharmaceutical industry has shown a growing interest in continuous twin-screw granulation (TSG). Despite flourishing literature on TSG, limited studies focused on fundamental process understanding on its mechanisms. In current study, granule quality attributes along the length of the TSG barrel were evaluated together with heat transfer in order to achieve a more fundamental understanding of the granulation process. An experimental setup was developed allowing the collection of granules at the different TSG compartments. In addition to the determination of typical granule attributes, mechanical energy, barrel and granule temperature (measured using an in-line implemented infra-red camera) were measured to evaluate heat transfer occurring at the different compartments and to relate them to granulation mechanisms. Collected data identified wetting enthalpy and friction forces as the main sources of heat along the granulator length. Wetting occurred in the wetting zone and generated temperature increase depending on liquid-to-solid ratio and powder wettability. In the kneading zones, granule temperature increase was proportional to mechanical energy. While it is usually admitted that granule consolidation and reshaping are the consequence of the high shear experienced by the granules, it was highlighted that most of the mechanical energy is converted into thermal energy with no correlation between mechanical energy and granule size distribution. Combined mass and energy balance of the granulation process are therefore necessary to capture the interaction between granule properties and physico-chemical and mechanical phenomena occurring in each compartment.

Authors+Show Affiliations

Laboratory of Pharmaceutical Process Analytical Technology, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium. Product Development, UCB, Braine l'Alleud, Belgium.Laboratory of Pharmaceutical Process Analytical Technology, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.Laboratory of Pharmaceutical Process Analytical Technology, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.Laboratory of Pharmaceutical Process Analytical Technology, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium.Chemical & Pharmaceutical Development, Pharma R&D, Bayer AG, Friedrich-Ebert-Straβe 217/333, 42117, Wuppertal, Germany.BIOMATH-Department of Mathematical Modelling, Statistics and Bio-informatics, Ghent University, Coupure Links 653, Ghent, Belgium.Laboratory of Pharmaceutical Process Analytical Technology, Ghent University, Ottergemsesteenweg 460, 9000, Ghent, Belgium. Thomas.debeer@ugent.be.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31428889

Citation

Stauffer, Fanny, et al. "Heat Transfer Evaluation During Twin-Screw Wet Granulation in View of Detailed Process Understanding." AAPS PharmSciTech, vol. 20, no. 7, 2019, p. 291.
Stauffer F, Ryckaert A, Van Hauwermeiren D, et al. Heat Transfer Evaluation During Twin-Screw Wet Granulation in View of Detailed Process Understanding. AAPS PharmSciTech. 2019;20(7):291.
Stauffer, F., Ryckaert, A., Van Hauwermeiren, D., Funke, A., Djuric, D., Nopens, I., & De Beer, T. (2019). Heat Transfer Evaluation During Twin-Screw Wet Granulation in View of Detailed Process Understanding. AAPS PharmSciTech, 20(7), 291. https://doi.org/10.1208/s12249-019-1483-z
Stauffer F, et al. Heat Transfer Evaluation During Twin-Screw Wet Granulation in View of Detailed Process Understanding. AAPS PharmSciTech. 2019 Aug 19;20(7):291. PubMed PMID: 31428889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heat Transfer Evaluation During Twin-Screw Wet Granulation in View of Detailed Process Understanding. AU - Stauffer,Fanny, AU - Ryckaert,Alexander, AU - Van Hauwermeiren,Daan, AU - Funke,Adrian, AU - Djuric,Dejan, AU - Nopens,Ingmar, AU - De Beer,Thomas, Y1 - 2019/08/19/ PY - 2019/04/12/received PY - 2019/07/16/accepted PY - 2019/8/21/entrez PY - 2019/8/21/pubmed PY - 2019/12/18/medline KW - heat transfer KW - twin-screw granulation SP - 291 EP - 291 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 20 IS - 7 N2 - During the last decade, the pharmaceutical industry has shown a growing interest in continuous twin-screw granulation (TSG). Despite flourishing literature on TSG, limited studies focused on fundamental process understanding on its mechanisms. In current study, granule quality attributes along the length of the TSG barrel were evaluated together with heat transfer in order to achieve a more fundamental understanding of the granulation process. An experimental setup was developed allowing the collection of granules at the different TSG compartments. In addition to the determination of typical granule attributes, mechanical energy, barrel and granule temperature (measured using an in-line implemented infra-red camera) were measured to evaluate heat transfer occurring at the different compartments and to relate them to granulation mechanisms. Collected data identified wetting enthalpy and friction forces as the main sources of heat along the granulator length. Wetting occurred in the wetting zone and generated temperature increase depending on liquid-to-solid ratio and powder wettability. In the kneading zones, granule temperature increase was proportional to mechanical energy. While it is usually admitted that granule consolidation and reshaping are the consequence of the high shear experienced by the granules, it was highlighted that most of the mechanical energy is converted into thermal energy with no correlation between mechanical energy and granule size distribution. Combined mass and energy balance of the granulation process are therefore necessary to capture the interaction between granule properties and physico-chemical and mechanical phenomena occurring in each compartment. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/31428889/Heat_Transfer_Evaluation_During_Twin_Screw_Wet_Granulation_in_View_of_Detailed_Process_Understanding_ L2 - https://dx.doi.org/10.1208/s12249-019-1483-z DB - PRIME DP - Unbound Medicine ER -