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Effects of misoprostol treatment on doxorubicin induced renal injury in rats.
Biotech Histochem 2019; :1-8BH

Abstract

We investigated the potential nephroprotective effects of misoprostol (MP) on doxorubicin (DOX) induced renal injury using histologic and biochemical assessment of rat kidneys. We used 21 male rats divided into three groups: group 1, control; group 2, DOX; group 3, DOX + MP. The control group was given 0.5 ml 0.9% NaCl and 1 ml 0.9% NaCl orally for 6 days. DOX was administered as a single dose of 20 mg/kg on day 3. MP was administered orally for 6 days. We found that treatment with MP decreased serum creatinine and blood urea nitrogen levels significantly. DOX increased the malondialdehyde level and decreased catalase, superoxide dismutase activities and glutathione level. These alterations were prevented in renal tissues by MP. MP also decreased NADPH oxidase-4 and caspase-3 levels. In the DOX + MP group, oxidative stress was decreased, antioxidant activity was increased and histopathological changes were reduced compared to the DOX group. Renal injury caused by DOX was attenuated by MP treatment owing to the antioxidative and anti-apoptotic effects of MP.

Authors+Show Affiliations

Department of Medical Biochemistry, Vocational School of Health Services, University of Adıyaman , Adıyaman , Turkey.Department of Histology and Embryology, Faculty of Medicine, Süleyman Demirel University , Isparta , Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31429311

Citation

Bilgic, S, and I Armagan. "Effects of Misoprostol Treatment On Doxorubicin Induced Renal Injury in Rats." Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission, 2019, pp. 1-8.
Bilgic S, Armagan I. Effects of misoprostol treatment on doxorubicin induced renal injury in rats. Biotech Histochem. 2019.
Bilgic, S., & Armagan, I. (2019). Effects of misoprostol treatment on doxorubicin induced renal injury in rats. Biotechnic & Histochemistry : Official Publication of the Biological Stain Commission, pp. 1-8. doi:10.1080/10520295.2019.1645356.
Bilgic S, Armagan I. Effects of Misoprostol Treatment On Doxorubicin Induced Renal Injury in Rats. Biotech Histochem. 2019 Aug 20;1-8. PubMed PMID: 31429311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of misoprostol treatment on doxorubicin induced renal injury in rats. AU - Bilgic,S, AU - Armagan,I, Y1 - 2019/08/20/ PY - 2019/8/21/entrez KW - Doxorubicin KW - misoprostol KW - oxidative stress KW - rat KW - renal injury SP - 1 EP - 8 JF - Biotechnic & histochemistry : official publication of the Biological Stain Commission JO - Biotech Histochem N2 - We investigated the potential nephroprotective effects of misoprostol (MP) on doxorubicin (DOX) induced renal injury using histologic and biochemical assessment of rat kidneys. We used 21 male rats divided into three groups: group 1, control; group 2, DOX; group 3, DOX + MP. The control group was given 0.5 ml 0.9% NaCl and 1 ml 0.9% NaCl orally for 6 days. DOX was administered as a single dose of 20 mg/kg on day 3. MP was administered orally for 6 days. We found that treatment with MP decreased serum creatinine and blood urea nitrogen levels significantly. DOX increased the malondialdehyde level and decreased catalase, superoxide dismutase activities and glutathione level. These alterations were prevented in renal tissues by MP. MP also decreased NADPH oxidase-4 and caspase-3 levels. In the DOX + MP group, oxidative stress was decreased, antioxidant activity was increased and histopathological changes were reduced compared to the DOX group. Renal injury caused by DOX was attenuated by MP treatment owing to the antioxidative and anti-apoptotic effects of MP. SN - 1473-7760 UR - https://www.unboundmedicine.com/medline/citation/31429311/Effects_of_misoprostol_treatment_on_doxorubicin_induced_renal_injury_in_rats L2 - http://www.tandfonline.com/doi/full/10.1080/10520295.2019.1645356 DB - PRIME DP - Unbound Medicine ER -