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Protective effects of a standardized extract (HemoHIM) using indomethacin- and ethanol/HCl-induced gastric mucosal injury models.
Pharm Biol. 2019 Dec; 57(1):543-549.PB

Abstract

Context:

HemoHIM is a medicinal herbal preparation of Angelica gigas Nakai (Apiaceae), Cnidium officinale Makino (Umbelliferae), and Paeonia japonica Miyabe (Paeoniaceae) developed for immune regulation. HemoHIM has been investigated for its ability to enhance tissue self-renewal and stimulate immune systems. To date, studies on the protective effects of HemoHIM against gastritis and gastric ulcers have not been conducted.

Objective:

The protective effects of HemoHIM using models of indomethacin and ethanol/hydrochloric acid (EtOH/HCl)-induced gastric mucosal injury were investigated. Materials and methods: Rats were divided into five groups (n = 10): control, indomethacin, or EtOH/HCl groups, HemoHIM 250, 500 mg kg-1, and cimetidine 100 mg kg-1, respectively. Indomethacin (80 mg kg-1) and 60% EtOH/150 mM HCl were administered orally 1 h after the administration of samples and rats were anesthetized 3 h after induction. The lesion area (%), inhibition ratio (%), and total acidity were investigated, and tissues were histopathologically analyzed using hematoxylin and-eosin (H&E) staining.

Results:

HemoHIM significantly reduced gastric injury in indomethacin-induced model (250 and 500 mg kg-1; 64.30% and 67.75%, p < 0.001) compared to indomethacin group. In the EtOH/HCl-induced model, HemoHIM reduced gastric lesion (250 and 500 mg kg-1; 61.05% and 73.37%, p < 0.001) and gastric acidity (250 and 500 mg kg-1; 37.80 and 45.20 meq L-1, p < 0.001) compared to EtOH/HCl group. H&E staining of the gastric mucosa showed decreased erosion and hemorrhage in HemoHIM group compared to EtOH/HCl group. Discussion and conclusions: Based on the results, HemoHIM is potential candidate for the treatment of gastritis and gastric ulcers.

Authors+Show Affiliations

Food Science R&D Center, Kolmar BNH Co., Ltd , Sejong-Si , Republic of Korea.Food Science R&D Center, Kolmar BNH Co., Ltd , Sejong-Si , Republic of Korea.Food Science R&D Center, Kolmar BNH Co., Ltd , Sejong-Si , Republic of Korea.Food Science R&D Center, Kolmar BNH Co., Ltd , Sejong-Si , Republic of Korea.Food Science R&D Center, Kolmar BNH Co., Ltd , Sejong-Si , Republic of Korea.Division for Biotechnology, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute (KAERI) , Jeonbuk , Republic of Korea.Division for Biotechnology, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute (KAERI) , Jeonbuk , Republic of Korea.Division for Biotechnology, Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute (KAERI) , Jeonbuk , Republic of Korea.Food Science R&D Center, Kolmar BNH Co., Ltd , Sejong-Si , Republic of Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31429615

Citation

Kwon, Da-Ae, et al. "Protective Effects of a Standardized Extract (HemoHIM) Using Indomethacin- and ethanol/HCl-induced Gastric Mucosal Injury Models." Pharmaceutical Biology, vol. 57, no. 1, 2019, pp. 543-549.
Kwon DA, Kim YS, Baek SH, et al. Protective effects of a standardized extract (HemoHIM) using indomethacin- and ethanol/HCl-induced gastric mucosal injury models. Pharm Biol. 2019;57(1):543-549.
Kwon, D. A., Kim, Y. S., Baek, S. H., Kim, S. K., Kim, H. K., Jo, S. K., Jung, U., Park, H. R., & Lee, H. S. (2019). Protective effects of a standardized extract (HemoHIM) using indomethacin- and ethanol/HCl-induced gastric mucosal injury models. Pharmaceutical Biology, 57(1), 543-549. https://doi.org/10.1080/13880209.2019.1651875
Kwon DA, et al. Protective Effects of a Standardized Extract (HemoHIM) Using Indomethacin- and ethanol/HCl-induced Gastric Mucosal Injury Models. Pharm Biol. 2019;57(1):543-549. PubMed PMID: 31429615.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Protective effects of a standardized extract (HemoHIM) using indomethacin- and ethanol/HCl-induced gastric mucosal injury models. AU - Kwon,Da-Ae, AU - Kim,Yong Sang, AU - Baek,Sin Hwa, AU - Kim,Seul-Ki, AU - Kim,Hyun Kyu, AU - Jo,Sung-Kee, AU - Jung,Uhee, AU - Park,Hae-Ran, AU - Lee,Hak Sung, PY - 2019/8/21/entrez PY - 2019/8/21/pubmed PY - 2020/2/6/medline KW - Makino KW - Miyabe KW - Nakai KW - Inflammation KW - gastric ulcer KW - gastritis SP - 543 EP - 549 JF - Pharmaceutical biology JO - Pharm Biol VL - 57 IS - 1 N2 - Context: HemoHIM is a medicinal herbal preparation of Angelica gigas Nakai (Apiaceae), Cnidium officinale Makino (Umbelliferae), and Paeonia japonica Miyabe (Paeoniaceae) developed for immune regulation. HemoHIM has been investigated for its ability to enhance tissue self-renewal and stimulate immune systems. To date, studies on the protective effects of HemoHIM against gastritis and gastric ulcers have not been conducted. Objective: The protective effects of HemoHIM using models of indomethacin and ethanol/hydrochloric acid (EtOH/HCl)-induced gastric mucosal injury were investigated. Materials and methods: Rats were divided into five groups (n = 10): control, indomethacin, or EtOH/HCl groups, HemoHIM 250, 500 mg kg-1, and cimetidine 100 mg kg-1, respectively. Indomethacin (80 mg kg-1) and 60% EtOH/150 mM HCl were administered orally 1 h after the administration of samples and rats were anesthetized 3 h after induction. The lesion area (%), inhibition ratio (%), and total acidity were investigated, and tissues were histopathologically analyzed using hematoxylin and-eosin (H&E) staining. Results: HemoHIM significantly reduced gastric injury in indomethacin-induced model (250 and 500 mg kg-1; 64.30% and 67.75%, p < 0.001) compared to indomethacin group. In the EtOH/HCl-induced model, HemoHIM reduced gastric lesion (250 and 500 mg kg-1; 61.05% and 73.37%, p < 0.001) and gastric acidity (250 and 500 mg kg-1; 37.80 and 45.20 meq L-1, p < 0.001) compared to EtOH/HCl group. H&E staining of the gastric mucosa showed decreased erosion and hemorrhage in HemoHIM group compared to EtOH/HCl group. Discussion and conclusions: Based on the results, HemoHIM is potential candidate for the treatment of gastritis and gastric ulcers. SN - 1744-5116 UR - https://www.unboundmedicine.com/medline/citation/31429615/Protective_effects_of_a_standardized_extract__HemoHIM__using_indomethacin__and_ethanol/HCl_induced_gastric_mucosal_injury_models_ L2 - https://www.tandfonline.com/doi/full/10.1080/13880209.2019.1651875 DB - PRIME DP - Unbound Medicine ER -