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Effects of the dutasteride and sildenafil association in the penis of a benign prostatic hyperplasia animal model.
Aging Male 2019; :1-7AM

Abstract

Objective:

The aim of this study was to investigate whether concomitant treatment of dutasteride and sildenafil could prevent structural changes in the penis of a BPH rodent model.

Methods:

Thirty-two adult male rats were divided into the following groups: Ctrl, untreated control rats; BPH, untreated spontaneously hypertensive rats (SHRs); BPH + D, SHRs treated with dutasteride; and BPH + DS, SHRs treated with dutasteride and sildenafil. All treatments were performed during 40 days, following which the penises were collected for histomorphometrical analysis. The results were compared via one-way ANOVA with Bonferroni's post-test, considering p values <.05 as significant.

Results:

The smooth muscle density decreased by 28.6% and 21.4% in BPH + D and BPH + DS, respectively, when compared to the BPH group. The sinusoid space density reduced by 32.2% in BPH, when compared to the Ctrl group; this density was also reduced by 22.6% in BPH + D, when compared to the BPH group. The density of the elastic fibers increased 51.6% and 65.6% in BPH + D and BPH + DS, when compared to the BPH group.

Conclusion:

Treatment with dutasteride promoted morphological changes in the corpus cavernous of this BPH model. Concomitant treatment with sildenafil did not prevent the morphological changes caused by dutasteride; on the contrary, it also promoted a further increase in elastic fibers.

Authors+Show Affiliations

Urogenital Research Unit, Rio De Janeiro State University , Rio De Janeiro , Brazil.Fundação Educacional Dom André Arcoverde , Valença , Brazil.Urogenital Research Unit, Rio De Janeiro State University , Rio De Janeiro , Brazil.Urogenital Research Unit, Rio De Janeiro State University , Rio De Janeiro , Brazil.Urogenital Research Unit, Rio De Janeiro State University , Rio De Janeiro , Brazil.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31429633

Citation

Da Silva, Marcello H A., et al. "Effects of the Dutasteride and Sildenafil Association in the Penis of a Benign Prostatic Hyperplasia Animal Model." The Aging Male : the Official Journal of the International Society for the Study of the Aging Male, 2019, pp. 1-7.
Da Silva MHA, Medeiros JL, Costa WS, et al. Effects of the dutasteride and sildenafil association in the penis of a benign prostatic hyperplasia animal model. Aging Male. 2019.
Da Silva, M. H. A., Medeiros, J. L., Costa, W. S., Sampaio, F. J. B., & De Souza, D. B. (2019). Effects of the dutasteride and sildenafil association in the penis of a benign prostatic hyperplasia animal model. The Aging Male : the Official Journal of the International Society for the Study of the Aging Male, pp. 1-7. doi:10.1080/13685538.2019.1653839.
Da Silva MHA, et al. Effects of the Dutasteride and Sildenafil Association in the Penis of a Benign Prostatic Hyperplasia Animal Model. Aging Male. 2019 Aug 20;1-7. PubMed PMID: 31429633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of the dutasteride and sildenafil association in the penis of a benign prostatic hyperplasia animal model. AU - Da Silva,Marcello H A, AU - Medeiros,Jorge L,Jr AU - Costa,Waldemar S, AU - Sampaio,Francisco J B, AU - De Souza,Diogo B, Y1 - 2019/08/20/ PY - 2019/8/21/entrez KW - Benign prostatic hyperplasia KW - dutasteride KW - erectile dysfunction KW - penis KW - sildenafil SP - 1 EP - 7 JF - The aging male : the official journal of the International Society for the Study of the Aging Male JO - Aging Male N2 - Objective: The aim of this study was to investigate whether concomitant treatment of dutasteride and sildenafil could prevent structural changes in the penis of a BPH rodent model. Methods: Thirty-two adult male rats were divided into the following groups: Ctrl, untreated control rats; BPH, untreated spontaneously hypertensive rats (SHRs); BPH + D, SHRs treated with dutasteride; and BPH + DS, SHRs treated with dutasteride and sildenafil. All treatments were performed during 40 days, following which the penises were collected for histomorphometrical analysis. The results were compared via one-way ANOVA with Bonferroni's post-test, considering p values <.05 as significant. Results: The smooth muscle density decreased by 28.6% and 21.4% in BPH + D and BPH + DS, respectively, when compared to the BPH group. The sinusoid space density reduced by 32.2% in BPH, when compared to the Ctrl group; this density was also reduced by 22.6% in BPH + D, when compared to the BPH group. The density of the elastic fibers increased 51.6% and 65.6% in BPH + D and BPH + DS, when compared to the BPH group. Conclusion: Treatment with dutasteride promoted morphological changes in the corpus cavernous of this BPH model. Concomitant treatment with sildenafil did not prevent the morphological changes caused by dutasteride; on the contrary, it also promoted a further increase in elastic fibers. SN - 1473-0790 UR - https://www.unboundmedicine.com/medline/citation/31429633/Effects_of_the_dutasteride_and_sildenafil_association_in_the_penis_of_a_benign_prostatic_hyperplasia_animal_model L2 - http://www.tandfonline.com/doi/full/10.1080/13685538.2019.1653839 DB - PRIME DP - Unbound Medicine ER -