Tags

Type your tag names separated by a space and hit enter

Magnetic Resonance Imaging of Idiopathic Intracranial Hypertension: Before and After Treatment.
J Neuroophthalmol. 2019 09; 39(3):324-329.JN

Abstract

BACKGROUND

This study aimed to identify the reversibility of MRI findings indicative of increased intracranial hypertension in idiopathic intracranial hypertension (IIH) patients after treatment.

METHODS

This retrospective, observational study included demographic and clinical data from 10 patients with IIH and 10 controls. Brain MRI findings in IIH patients were recorded twice: once when patients had papilledema and again after resolution of papilledema. Neuroradiologists graded MRI findings in both groups based on an imaging grading scale.

RESULTS

After resolution of papilledema, all patients showed improvement in 2 or more of the MRI characteristics of IIH. This was especially the case for the height of the midsagittal pituitary gland and optic nerve sheath thickness (ONST), which were significantly different in all pairwise group comparisons. Sellar configuration, globe configuration, and horizontal orbital optic nerve tortuosity were different between the IIH pre-treatment group and controls, but not between controls and the IIH post-treatment group. We found no difference in optic nerve head hyperintensity or optic nerve thickness among the 3 groups.

CONCLUSIONS

We demonstrated that several morphometric MRI characteristics in IIH are reversible to a certain extent after treatment. Enlarged subarachnoid spaces filled with cerebrospinal fluid seem to remain reduced, and the ONST and height of the pituitary gland are not fully normalized after treatment.

Authors+Show Affiliations

Gazi University Faculty of Medicine (HZBC, BN), Department of Neurology, Ankara, Turkey; Gazi University Faculty of Medicine (MU, NT), Department of Radiology, Ankara, Turkey; and Gazi University Faculty of Medicine (MH), Department of Ophthalmology, Ankara, Turkey.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31430269

Citation

Batur Caglayan, Hale Z., et al. "Magnetic Resonance Imaging of Idiopathic Intracranial Hypertension: Before and After Treatment." Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society, vol. 39, no. 3, 2019, pp. 324-329.
Batur Caglayan HZ, Ucar M, Hasanreisoglu M, et al. Magnetic Resonance Imaging of Idiopathic Intracranial Hypertension: Before and After Treatment. J Neuroophthalmol. 2019;39(3):324-329.
Batur Caglayan, H. Z., Ucar, M., Hasanreisoglu, M., Nazliel, B., & Tokgoz, N. (2019). Magnetic Resonance Imaging of Idiopathic Intracranial Hypertension: Before and After Treatment. Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society, 39(3), 324-329. https://doi.org/10.1097/WNO.0000000000000792
Batur Caglayan HZ, et al. Magnetic Resonance Imaging of Idiopathic Intracranial Hypertension: Before and After Treatment. J Neuroophthalmol. 2019;39(3):324-329. PubMed PMID: 31430269.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Magnetic Resonance Imaging of Idiopathic Intracranial Hypertension: Before and After Treatment. AU - Batur Caglayan,Hale Z, AU - Ucar,Murat, AU - Hasanreisoglu,Murat, AU - Nazliel,Bijen, AU - Tokgoz,Nil, PY - 2019/8/21/entrez PY - 2019/8/21/pubmed PY - 2020/6/17/medline SP - 324 EP - 329 JF - Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society JO - J Neuroophthalmol VL - 39 IS - 3 N2 - BACKGROUND: This study aimed to identify the reversibility of MRI findings indicative of increased intracranial hypertension in idiopathic intracranial hypertension (IIH) patients after treatment. METHODS: This retrospective, observational study included demographic and clinical data from 10 patients with IIH and 10 controls. Brain MRI findings in IIH patients were recorded twice: once when patients had papilledema and again after resolution of papilledema. Neuroradiologists graded MRI findings in both groups based on an imaging grading scale. RESULTS: After resolution of papilledema, all patients showed improvement in 2 or more of the MRI characteristics of IIH. This was especially the case for the height of the midsagittal pituitary gland and optic nerve sheath thickness (ONST), which were significantly different in all pairwise group comparisons. Sellar configuration, globe configuration, and horizontal orbital optic nerve tortuosity were different between the IIH pre-treatment group and controls, but not between controls and the IIH post-treatment group. We found no difference in optic nerve head hyperintensity or optic nerve thickness among the 3 groups. CONCLUSIONS: We demonstrated that several morphometric MRI characteristics in IIH are reversible to a certain extent after treatment. Enlarged subarachnoid spaces filled with cerebrospinal fluid seem to remain reduced, and the ONST and height of the pituitary gland are not fully normalized after treatment. SN - 1536-5166 UR - https://www.unboundmedicine.com/medline/citation/31430269/Magnetic_Resonance_Imaging_of_Idiopathic_Intracranial_Hypertension:_Before_and_After_Treatment_ L2 - https://doi.org/10.1097/WNO.0000000000000792 DB - PRIME DP - Unbound Medicine ER -