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Reproducibility of Microperimeter 3 (MP-3) Microperimetry in Open-Angle Glaucoma Patients.
Ophthalmic Res 2019; :1-7OR

Abstract

PURPOSE

Primary open-angle glaucoma (POAG) is a chronic progressive optic neuropathy, leading to degeneration of retinal ganglion cells and characteristic morphological changes at the optic disc. In advanced stages of the disease, functional tests, such as standard automated perimetry (SAP), are the main diagnostic tools to detect progression. Compared to SAP, microperimetry offers fundus imaging with motion tracking to ensure precise stimulation of certain locations of the retina. Aim of the study was to assess reproducibility of microperimetry compared to SAP in patients with POAG.

METHODS

This prospective monocenter study included patients suffering from POAG with visual field defects in the central 20° zone. After inclusion into the study, 3 consecutive study visits were scheduled within 1 month, assessing microperimetry and SAP at each visit.

RESULTS

From 19 patients recruited, data from 18 patients could be analyzed. No significant difference between study visits could be detected in mean retinal sensitivity in microperimetry and SAP (microperimetry p = 0.401; SAP p = 0.644; Friedman's 2-way analysis of variance). The intraclass-correlation coefficient was 0.981 (95% CI 0.978-0.984) for microperimetry and 0.948 (95% CI 0.941-0.955) for SAP. Absolute agreement between deep scotoma points was found in 81 test locations (79%) in microperimetry and in 35 test locations (20%) in SAP (p = 0.003, chi-square test).

CONCLUSIONS

Microperimetry and conventional perimetry showed high reproducibility, with slightly better performance of microperimetry. However, the reduced angle of visual field in microperimetry limits its application to central glaucomatous field damage.

Authors+Show Affiliations

Vienna Institute for Research in Ocular Surgery, A Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria.Vienna Institute for Research in Ocular Surgery, A Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria.Vienna Institute for Research in Ocular Surgery, A Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria.Vienna Institute for Research in Ocular Surgery, A Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria.Vienna Institute for Research in Ocular Surgery, A Karl Landsteiner Institute, Hanusch Hospital, Vienna, Austria, oliver@findl.at.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31430750

Citation

Leisser, Christoph, et al. "Reproducibility of Microperimeter 3 (MP-3) Microperimetry in Open-Angle Glaucoma Patients." Ophthalmic Research, 2019, pp. 1-7.
Leisser C, Palkovits S, Hirnschall N, et al. Reproducibility of Microperimeter 3 (MP-3) Microperimetry in Open-Angle Glaucoma Patients. Ophthalmic Res. 2019.
Leisser, C., Palkovits, S., Hirnschall, N., Georgiev, S., & Findl, O. (2019). Reproducibility of Microperimeter 3 (MP-3) Microperimetry in Open-Angle Glaucoma Patients. Ophthalmic Research, pp. 1-7. doi:10.1159/000501693.
Leisser C, et al. Reproducibility of Microperimeter 3 (MP-3) Microperimetry in Open-Angle Glaucoma Patients. Ophthalmic Res. 2019 Aug 20;1-7. PubMed PMID: 31430750.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reproducibility of Microperimeter 3 (MP-3) Microperimetry in Open-Angle Glaucoma Patients. AU - Leisser,Christoph, AU - Palkovits,Stefan, AU - Hirnschall,Nino, AU - Georgiev,Stefan, AU - Findl,Oliver, Y1 - 2019/08/20/ PY - 2019/01/14/received PY - 2019/06/21/accepted PY - 2019/8/21/entrez PY - 2019/8/21/pubmed PY - 2019/8/21/medline KW - Glaucoma KW - Microperimeter 3 KW - Microperimetry KW - Visual field SP - 1 EP - 7 JF - Ophthalmic research JO - Ophthalmic Res. N2 - PURPOSE: Primary open-angle glaucoma (POAG) is a chronic progressive optic neuropathy, leading to degeneration of retinal ganglion cells and characteristic morphological changes at the optic disc. In advanced stages of the disease, functional tests, such as standard automated perimetry (SAP), are the main diagnostic tools to detect progression. Compared to SAP, microperimetry offers fundus imaging with motion tracking to ensure precise stimulation of certain locations of the retina. Aim of the study was to assess reproducibility of microperimetry compared to SAP in patients with POAG. METHODS: This prospective monocenter study included patients suffering from POAG with visual field defects in the central 20° zone. After inclusion into the study, 3 consecutive study visits were scheduled within 1 month, assessing microperimetry and SAP at each visit. RESULTS: From 19 patients recruited, data from 18 patients could be analyzed. No significant difference between study visits could be detected in mean retinal sensitivity in microperimetry and SAP (microperimetry p = 0.401; SAP p = 0.644; Friedman's 2-way analysis of variance). The intraclass-correlation coefficient was 0.981 (95% CI 0.978-0.984) for microperimetry and 0.948 (95% CI 0.941-0.955) for SAP. Absolute agreement between deep scotoma points was found in 81 test locations (79%) in microperimetry and in 35 test locations (20%) in SAP (p = 0.003, chi-square test). CONCLUSIONS: Microperimetry and conventional perimetry showed high reproducibility, with slightly better performance of microperimetry. However, the reduced angle of visual field in microperimetry limits its application to central glaucomatous field damage. SN - 1423-0259 UR - https://www.unboundmedicine.com/medline/citation/31430750/Reproducibility_of_Microperimeter_3_(MP-3)_Microperimetry_in_Open-Angle_Glaucoma_Patients L2 - https://www.karger.com?DOI=10.1159/000501693 DB - PRIME DP - Unbound Medicine ER -