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Extramedullary Hematopoiesis: An Unusual Finding in Angiolymphoid Hyperplasia With Eosinophilia.
Am J Dermatopathol 2019; 41(9):680-683AJ

Abstract

Extramedullary hematopoiesis is the process of blood cell synthesis occurring outside the medulla of the bone marrow. During fetal development, extramedullary hematopoiesis is considered physiological; however, it is considered pathologic when occurring outside the neonatal period. Angiolymphoid hyperplasia with eosinophilia (ALHE) describes a lesion characterized histologically by plump endothelial cells associated with a mixed inflammatory infiltrate of lymphocytes, plasma cells, mast cells, and eosinophils. This report describes an adolescent boy with an isolated preauricular facial lesion. After excision, histopathology confirmed a diagnosis of ALHE with the additional finding of trilineage extramedullary hematopoiesis. To the authors' knowledge, this is the first reported case of extramedullary hematopoiesis in ALHE.

Authors+Show Affiliations

Department of Internal Medicine, Dermatology Division, Carilion Clinic and Virginia Tech Carilion School of Medicine, Roanoke, VA; and Edward Via College of Osteopathic Medicine, Blacksburg, VA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31433794

Citation

Johnson, Nathan M., et al. "Extramedullary Hematopoiesis: an Unusual Finding in Angiolymphoid Hyperplasia With Eosinophilia." The American Journal of Dermatopathology, vol. 41, no. 9, 2019, pp. 680-683.
Johnson NM, Thomas RJ, Grider DJ. Extramedullary Hematopoiesis: An Unusual Finding in Angiolymphoid Hyperplasia With Eosinophilia. Am J Dermatopathol. 2019;41(9):680-683.
Johnson, N. M., Thomas, R. J., & Grider, D. J. (2019). Extramedullary Hematopoiesis: An Unusual Finding in Angiolymphoid Hyperplasia With Eosinophilia. The American Journal of Dermatopathology, 41(9), pp. 680-683. doi:10.1097/DAD.0000000000001407.
Johnson NM, Thomas RJ, Grider DJ. Extramedullary Hematopoiesis: an Unusual Finding in Angiolymphoid Hyperplasia With Eosinophilia. Am J Dermatopathol. 2019;41(9):680-683. PubMed PMID: 31433794.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extramedullary Hematopoiesis: An Unusual Finding in Angiolymphoid Hyperplasia With Eosinophilia. AU - Johnson,Nathan M, AU - Thomas,Raj J, AU - Grider,Douglas J, PY - 2019/8/22/entrez SP - 680 EP - 683 JF - The American Journal of dermatopathology JO - Am J Dermatopathol VL - 41 IS - 9 N2 - Extramedullary hematopoiesis is the process of blood cell synthesis occurring outside the medulla of the bone marrow. During fetal development, extramedullary hematopoiesis is considered physiological; however, it is considered pathologic when occurring outside the neonatal period. Angiolymphoid hyperplasia with eosinophilia (ALHE) describes a lesion characterized histologically by plump endothelial cells associated with a mixed inflammatory infiltrate of lymphocytes, plasma cells, mast cells, and eosinophils. This report describes an adolescent boy with an isolated preauricular facial lesion. After excision, histopathology confirmed a diagnosis of ALHE with the additional finding of trilineage extramedullary hematopoiesis. To the authors' knowledge, this is the first reported case of extramedullary hematopoiesis in ALHE. SN - 1533-0311 UR - https://www.unboundmedicine.com/medline/citation/31433794/Extramedullary_Hematopoiesis:_An_Unusual_Finding_in_Angiolymphoid_Hyperplasia_With_Eosinophilia L2 - http://dx.doi.org/10.1097/DAD.0000000000001407 DB - PRIME DP - Unbound Medicine ER -