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Salivary gland involvement disparities in clinical characteristics of IgG4-related disease: a retrospective study of 428 patients.

Abstract

OBJECTIVES

IgG4-related disease (IgG4-RD) has recently been recognized as a fibro-inflammatory condition featuring tumefactive lesions in multiple organs, and the salivary gland is one of the most commonly involved sites. We undertook this study to compare detailed demographic, clinical and laboratory characteristics of IgG4-RD patients with salivary gland lesions (IgG4-RD SG+) and salivary-gland-free IgG4-RD (IgG4-RD SG-) in a large cohort.

METHODS

We carried out a retrospective review of the medical records of 428 cases of IgG4-RD diagnosed at Peking University People's Hospital between March 2006 and May 2018.

RESULTS

Among 428 patients, 249 had salivary glands that were affected. IgG4-RD SG+ patients showed younger age at disease onset and diagnosis, and a longer interval between symptom onset and diagnosis. The IgG4-RD SG+ group involved more female patients, and allergic diseases were more common in this group. In terms of organ involvement, the IgG4-RD SG+ group were more frequently presented with lacrimal gland involvement, while lymph node, retroperitoneal fibrosis, pancreas, biliary system, kidney and aorta were more prominent in the IgG4-RD SG- group. In addition, the serum IgG4 level, IgG4/IgG ratio and IgE level were significantly higher in IgG4-RD SG+ patients. Patients with eosinophilia were more common in the IgG4-RD SG+ group, while elevated ESR, CRP and positive ANA were more common in the IgG4-RD SG- group.

CONCLUSION

We have revealed demographic, clinical and laboratory differences between IgG4-RD SG+ and SG- patients, which indicated potential differences in pathogenesis and important implications for the diagnosis and management of these two phenotypes.

Authors+Show Affiliations

Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing.Department of Rheumatology and Immunology, The First Hospital of Lanzhou University, Lanzhou.Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing.Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing.Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing.Department of Oral and Maxillofacial Surgery, Peking University School of Stomatology.Department of Ultrasound.Department of Radiology.Department of Pathology.Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.Department of Oral and Maxillofacial Surgery, Peking University School of Stomatology.Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31436287

Citation

Liu, Yanying, et al. "Salivary Gland Involvement Disparities in Clinical Characteristics of IgG4-related Disease: a Retrospective Study of 428 Patients." Rheumatology (Oxford, England), 2019.
Liu Y, Xue M, Wang Z, et al. Salivary gland involvement disparities in clinical characteristics of IgG4-related disease: a retrospective study of 428 patients. Rheumatology (Oxford). 2019.
Liu, Y., Xue, M., Wang, Z., Zeng, Q., Ren, L., Zhang, Y., ... Li, Z. G. (2019). Salivary gland involvement disparities in clinical characteristics of IgG4-related disease: a retrospective study of 428 patients. Rheumatology (Oxford, England), doi:10.1093/rheumatology/kez280.
Liu Y, et al. Salivary Gland Involvement Disparities in Clinical Characteristics of IgG4-related Disease: a Retrospective Study of 428 Patients. Rheumatology (Oxford). 2019 Aug 21; PubMed PMID: 31436287.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Salivary gland involvement disparities in clinical characteristics of IgG4-related disease: a retrospective study of 428 patients. AU - Liu,Yanying, AU - Xue,Miao, AU - Wang,Zhenfan, AU - Zeng,Qiaozhu, AU - Ren,Limin, AU - Zhang,Yanyan, AU - Zhang,Shanshan, AU - Wang,Yi, AU - Shen,Danhua, AU - Xia,Changsheng, AU - Yu,Guangyan, AU - Li,Zhan-Guo, Y1 - 2019/08/21/ PY - 2019/02/23/received PY - 2019/05/08/revised PY - 2019/8/23/entrez KW - IgG4-related disease KW - clinical characteristics KW - disparities KW - salivary gland JF - Rheumatology (Oxford, England) JO - Rheumatology (Oxford) N2 - OBJECTIVES: IgG4-related disease (IgG4-RD) has recently been recognized as a fibro-inflammatory condition featuring tumefactive lesions in multiple organs, and the salivary gland is one of the most commonly involved sites. We undertook this study to compare detailed demographic, clinical and laboratory characteristics of IgG4-RD patients with salivary gland lesions (IgG4-RD SG+) and salivary-gland-free IgG4-RD (IgG4-RD SG-) in a large cohort. METHODS: We carried out a retrospective review of the medical records of 428 cases of IgG4-RD diagnosed at Peking University People's Hospital between March 2006 and May 2018. RESULTS: Among 428 patients, 249 had salivary glands that were affected. IgG4-RD SG+ patients showed younger age at disease onset and diagnosis, and a longer interval between symptom onset and diagnosis. The IgG4-RD SG+ group involved more female patients, and allergic diseases were more common in this group. In terms of organ involvement, the IgG4-RD SG+ group were more frequently presented with lacrimal gland involvement, while lymph node, retroperitoneal fibrosis, pancreas, biliary system, kidney and aorta were more prominent in the IgG4-RD SG- group. In addition, the serum IgG4 level, IgG4/IgG ratio and IgE level were significantly higher in IgG4-RD SG+ patients. Patients with eosinophilia were more common in the IgG4-RD SG+ group, while elevated ESR, CRP and positive ANA were more common in the IgG4-RD SG- group. CONCLUSION: We have revealed demographic, clinical and laboratory differences between IgG4-RD SG+ and SG- patients, which indicated potential differences in pathogenesis and important implications for the diagnosis and management of these two phenotypes. SN - 1462-0332 UR - https://www.unboundmedicine.com/medline/citation/31436287/Salivary_gland_involvement_disparities_in_clinical_characteristics_of_IgG4-related_disease:_a_retrospective_study_of_428_patients L2 - https://academic.oup.com/rheumatology/article-lookup/doi/10.1093/rheumatology/kez280 DB - PRIME DP - Unbound Medicine ER -