Tags

Type your tag names separated by a space and hit enter

White Environment Can Be Used as an Aversive Stimulus in Zebrafish Inhibitory Avoidance Learning.
Zebrafish. 2019 10; 16(5):443-450.Z

Abstract

The two-factor theory predicts that the acquisition of avoidance responses is dependent on fear reduction; as such, drugs that reduce or increase fear or anxiety states should alter inhibitory avoidance (IA) acquisition. The present experiment used white spaces as aversive unconditioned stimuli in IA in zebrafish. Adult zebrafishes were tested in three experiments: validation of white compartment as aversive in IA; open field test; and effect of antidepressant (fluoxetine, imipramine) and anxiolytic (diazepam, clonazepam). The data show the effectiveness of the white compartment as an aversive stimulus in IA. Antidepressant fluoxetine did not alter and imipramine impairs avoidance acquisition in higher doses. Imipramine also produced a sedative effect in lower doses. Anxiolytic and stimulant drugs facilitated learning at doses which did not impair locomotion, suggesting that pharmacological manipulation of other factors in addition to fear/anxiety can impact aversive learning in zebrafish.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Santos BRD
Laboratório de Neurociência e Comportamento, Núcleo de Teoria e Pesquisa do Comportamento, Universidade Federal do Pará, Belém, Pará, Brazil. Faculdade de Psicologia, Instituto de Filosofia e Ciências Humanas, Universidade Federal do Pará, Belém, Pará, Brazil.
Santos RCD
Laboratório de Neurociência e Comportamento, Núcleo de Teoria e Pesquisa do Comportamento, Universidade Federal do Pará, Belém, Pará, Brazil.
Dias CAGM
Laboratório de Neurociência e Comportamento, Núcleo de Teoria e Pesquisa do Comportamento, Universidade Federal do Pará, Belém, Pará, Brazil. Laboratório de Neurociência e Comportamento 2, Instituto Federal do Amapá, Macapá/AP, Brazil.
Maximino C
Núcleo de Estudos em Psicologia Experimental, Instituto de Estudo em Saúde e Biológicas, Universidade do Sul e Sudeste do Pará, Marabá, Pará, Brazil.
Gouveia A
Laboratório de Neurociência e Comportamento, Núcleo de Teoria e Pesquisa do Comportamento, Universidade Federal do Pará, Belém, Pará, Brazil.

MeSH

AnimalsAntidepressive Agents, TricyclicAvoidance LearningFemaleFluoxetineImipramineMaleMaze LearningSelective Serotonin Reuptake InhibitorsZebrafish

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31436486

Citation

Santos, Bruno Rodrigues Dos, et al. "White Environment Can Be Used as an Aversive Stimulus in Zebrafish Inhibitory Avoidance Learning." Zebrafish, vol. 16, no. 5, 2019, pp. 443-450.
Santos BRD, Santos RCD, Dias CAGM, et al. White Environment Can Be Used as an Aversive Stimulus in Zebrafish Inhibitory Avoidance Learning. Zebrafish. 2019;16(5):443-450.
Santos, B. R. D., Santos, R. C. D., Dias, C. A. G. M., Maximino, C., & Gouveia, A. (2019). White Environment Can Be Used as an Aversive Stimulus in Zebrafish Inhibitory Avoidance Learning. Zebrafish, 16(5), 443-450. https://doi.org/10.1089/zeb.2019.1743
Santos BRD, et al. White Environment Can Be Used as an Aversive Stimulus in Zebrafish Inhibitory Avoidance Learning. Zebrafish. 2019;16(5):443-450. PubMed PMID: 31436486.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - White Environment Can Be Used as an Aversive Stimulus in Zebrafish Inhibitory Avoidance Learning. AU - Santos,Bruno Rodrigues Dos, AU - Santos,Raissa Cruz Dos, AU - Dias,Claudio Alberto Gellis de Mattos, AU - Maximino,Caio, AU - Gouveia,Amauri,Jr Y1 - 2019/08/22/ PY - 2019/8/23/pubmed PY - 2019/12/4/medline PY - 2019/8/23/entrez KW - anxiety KW - inhibitory avoidance KW - learning KW - psychiatric drugs KW - zebrafish SP - 443 EP - 450 JF - Zebrafish JO - Zebrafish VL - 16 IS - 5 N2 - The two-factor theory predicts that the acquisition of avoidance responses is dependent on fear reduction; as such, drugs that reduce or increase fear or anxiety states should alter inhibitory avoidance (IA) acquisition. The present experiment used white spaces as aversive unconditioned stimuli in IA in zebrafish. Adult zebrafishes were tested in three experiments: validation of white compartment as aversive in IA; open field test; and effect of antidepressant (fluoxetine, imipramine) and anxiolytic (diazepam, clonazepam). The data show the effectiveness of the white compartment as an aversive stimulus in IA. Antidepressant fluoxetine did not alter and imipramine impairs avoidance acquisition in higher doses. Imipramine also produced a sedative effect in lower doses. Anxiolytic and stimulant drugs facilitated learning at doses which did not impair locomotion, suggesting that pharmacological manipulation of other factors in addition to fear/anxiety can impact aversive learning in zebrafish. SN - 1557-8542 UR - https://www.unboundmedicine.com/medline/citation/31436486/White_Environment_Can_Be_Used_as_an_Aversive_Stimulus_in_Zebrafish_Inhibitory_Avoidance_Learning_ DB - PRIME DP - Unbound Medicine ER -