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Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019.
Emerg Infect Dis. 2019 11; 25(11):2108-2111.EI

Abstract

In 2019, influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic gene, which confers reduced susceptibility to baloxavir, were detected in Japan in an infant without baloxavir exposure and a baloxavir-treated sibling. These viruses' whole-genome sequences were identical, indicating human-to-human transmission. Influenza virus isolates should be monitored for baloxavir susceptibility.

Links

PMC Free PDF

Authors

Takashita E
No affiliation info available
Ichikawa M
No affiliation info available
Morita H
No affiliation info available
Ogawa R
No affiliation info available
Fujisaki S
No affiliation info available
Shirakura M
No affiliation info available
Miura H
No affiliation info available
Nakamura K
No affiliation info available
Kishida N
No affiliation info available
Kuwahara T
No affiliation info available
Sugawara H
No affiliation info available
Sato A
No affiliation info available
Akimoto M
No affiliation info available
Mitamura K
No affiliation info available
Abe T
No affiliation info available
Yamazaki M
No affiliation info available
Watanabe S
No affiliation info available
Hasegawa H
No affiliation info available
Odagiri T
No affiliation info available

MeSH

AdolescentAdultAntiviral AgentsChildDibenzothiepinsDisease SusceptibilityHumansInfantInfluenza A Virus, H3N2 SubtypeInfluenza, HumanJapanMiddle AgedMorpholinesMutationOxazinesPyridinesPyridonesThiepinsTriazinesYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31436527

Clinical Trial Links

Pilot of Cohort of Households for Influenza Monitoring and Evaluation in Seattle

Citation

Takashita, Emi, et al. "Human-to-Human Transmission of Influenza A(H3N2) Virus With Reduced Susceptibility to Baloxavir, Japan, February 2019." Emerging Infectious Diseases, vol. 25, no. 11, 2019, pp. 2108-2111.
Takashita E, Ichikawa M, Morita H, et al. Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019. Emerg Infect Dis. 2019;25(11):2108-2111.
Takashita, E., Ichikawa, M., Morita, H., Ogawa, R., Fujisaki, S., Shirakura, M., Miura, H., Nakamura, K., Kishida, N., Kuwahara, T., Sugawara, H., Sato, A., Akimoto, M., Mitamura, K., Abe, T., Yamazaki, M., Watanabe, S., Hasegawa, H., & Odagiri, T. (2019). Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019. Emerging Infectious Diseases, 25(11), 2108-2111. https://doi.org/10.3201/eid2511.190757
Takashita E, et al. Human-to-Human Transmission of Influenza A(H3N2) Virus With Reduced Susceptibility to Baloxavir, Japan, February 2019. Emerg Infect Dis. 2019;25(11):2108-2111. PubMed PMID: 31436527.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Human-to-Human Transmission of Influenza A(H3N2) Virus with Reduced Susceptibility to Baloxavir, Japan, February 2019. AU - Takashita,Emi, AU - Ichikawa,Masataka, AU - Morita,Hiroko, AU - Ogawa,Rie, AU - Fujisaki,Seiichiro, AU - Shirakura,Masayuki, AU - Miura,Hideka, AU - Nakamura,Kazuya, AU - Kishida,Noriko, AU - Kuwahara,Tomoko, AU - Sugawara,Hiromi, AU - Sato,Aya, AU - Akimoto,Miki, AU - Mitamura,Keiko, AU - Abe,Takashi, AU - Yamazaki,Masahiko, AU - Watanabe,Shinji, AU - Hasegawa,Hideki, AU - Odagiri,Takato, Y1 - 2019/11/17/ PY - 2019/8/23/pubmed PY - 2020/4/9/medline PY - 2019/8/23/entrez KW - H3N2 KW - I38T substitution KW - Japan KW - antimicrobial resistance KW - baloxavir KW - baloxavir acid KW - baloxavir marboxil KW - cap-dependent endonuclease inhibitor KW - family cluster KW - human-to-human transmission KW - influenza KW - influenza A(H1N1)pdm09 KW - influenza virus KW - polymerase acidic KW - respiratory infections KW - viruses KW - whole-genome sequencing SP - 2108 EP - 2111 JF - Emerging infectious diseases JO - Emerg Infect Dis VL - 25 IS - 11 N2 - In 2019, influenza A(H3N2) viruses carrying an I38T substitution in the polymerase acidic gene, which confers reduced susceptibility to baloxavir, were detected in Japan in an infant without baloxavir exposure and a baloxavir-treated sibling. These viruses' whole-genome sequences were identical, indicating human-to-human transmission. Influenza virus isolates should be monitored for baloxavir susceptibility. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/31436527/Human_to_Human_Transmission_of_Influenza_A_H3N2__Virus_with_Reduced_Susceptibility_to_Baloxavir_Japan_February_2019_ DB - PRIME DP - Unbound Medicine ER -