Tags

Type your tag names separated by a space and hit enter

Peculiar vegetative tumor-like genital herpes simplex nodules with brisk tissue eosinophilia in patients with human immunodeficiency virus infection.

Abstract

Genital herpes simplex virus (HSV) infection in a human immunodeficiency virus (HIV) patient can present as a vegetative nodule. Clinical differential diagnoses of the nodule include condyloma latum, condyloma acuminatum, viral or fungal infection, and cutaneous neoplasms. Histological examination of herpetic nodules has been reported to show thick pseudoepitheliomatous hyperplasia with dense dermal lymphoplasmacytic infiltrate and multifocal multinucleated cells with herpetic viral cytopathic changes. We report two patients with HIV presenting with vegetative tumor-like HSV nodules with distinctive histopathologic pattern of inflammation that has not been described in the literature before. All samples displayed slightly acanthotic epidermis with focal ulceration, dense dermal sclerosis, scattered plasma cells, and a brisk lymphoeosinophilic infiltrate found dissecting between dense collagen bundles. This pattern of inflammation is an important clue that can guide the pathologist to look for focal herpetic viral changes in the epidermis, as patients with HIV possibly tend to amount a predominantly eosinophilic immune response in inflammatory skin conditions.

Authors+Show Affiliations

Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York.Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York.Department of Dermatology, SUNY Downstate Medical Center, Brooklyn, New York. Department of Pathology, SUNY Downstate Medical Center, Brooklyn, New York.Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York.Department of Dermatology, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Lake Success, New York.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

31437312

Citation

Pomerantz, Hyemin, et al. "Peculiar Vegetative Tumor-like Genital Herpes Simplex Nodules With Brisk Tissue Eosinophilia in Patients With Human Immunodeficiency Virus Infection." Journal of Cutaneous Pathology, 2019.
Pomerantz H, Wang H, Heilman ER, et al. Peculiar vegetative tumor-like genital herpes simplex nodules with brisk tissue eosinophilia in patients with human immunodeficiency virus infection. J Cutan Pathol. 2019.
Pomerantz, H., Wang, H., Heilman, E. R., Sharon, V. R., & Gottesman, S. P. (2019). Peculiar vegetative tumor-like genital herpes simplex nodules with brisk tissue eosinophilia in patients with human immunodeficiency virus infection. Journal of Cutaneous Pathology, doi:10.1111/cup.13568.
Pomerantz H, et al. Peculiar Vegetative Tumor-like Genital Herpes Simplex Nodules With Brisk Tissue Eosinophilia in Patients With Human Immunodeficiency Virus Infection. J Cutan Pathol. 2019 Aug 22; PubMed PMID: 31437312.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peculiar vegetative tumor-like genital herpes simplex nodules with brisk tissue eosinophilia in patients with human immunodeficiency virus infection. AU - Pomerantz,Hyemin, AU - Wang,Hongbei, AU - Heilman,Edward R, AU - Sharon,Victoria R, AU - Gottesman,Silvija P, Y1 - 2019/08/22/ PY - 2019/04/12/received PY - 2019/08/12/revised PY - 2019/08/14/accepted PY - 2019/8/23/pubmed PY - 2019/8/23/medline PY - 2019/8/23/entrez KW - herpes simplex virus infection KW - human immunodeficiency virus KW - lymphoeosinophilic infiltrate KW - vegetative genital nodule JF - Journal of cutaneous pathology JO - J. Cutan. Pathol. N2 - Genital herpes simplex virus (HSV) infection in a human immunodeficiency virus (HIV) patient can present as a vegetative nodule. Clinical differential diagnoses of the nodule include condyloma latum, condyloma acuminatum, viral or fungal infection, and cutaneous neoplasms. Histological examination of herpetic nodules has been reported to show thick pseudoepitheliomatous hyperplasia with dense dermal lymphoplasmacytic infiltrate and multifocal multinucleated cells with herpetic viral cytopathic changes. We report two patients with HIV presenting with vegetative tumor-like HSV nodules with distinctive histopathologic pattern of inflammation that has not been described in the literature before. All samples displayed slightly acanthotic epidermis with focal ulceration, dense dermal sclerosis, scattered plasma cells, and a brisk lymphoeosinophilic infiltrate found dissecting between dense collagen bundles. This pattern of inflammation is an important clue that can guide the pathologist to look for focal herpetic viral changes in the epidermis, as patients with HIV possibly tend to amount a predominantly eosinophilic immune response in inflammatory skin conditions. SN - 1600-0560 UR - https://www.unboundmedicine.com/medline/citation/31437312/Peculiar_vegetative_tumor-like_genital_herpes_simplex_nodules_with_brisk_tissue_eosinophilia_in_patients_with_human_immunodeficiency_virus_infection L2 - https://doi.org/10.1111/cup.13568 DB - PRIME DP - Unbound Medicine ER -