Tags

Type your tag names separated by a space and hit enter

Umbelliferone reduces the expression of inflammatory chemokines in HaCaT cells and DNCB/DFE-induced atopic dermatitis symptoms in mice.
Int Immunopharmacol 2019; 75:105830II

Abstract

Umbelliferone (UMB) is a coumarin derivative present in roots and barks of plants, such as Angelica decursiva, Artemisia capillaris, and orange. UMB has been previously reported to exhibit anti-inflammatory, anti-diabetic, and anti-cancer effects. However, the effect of UMB on atopic dermatitis (AD) remains unknown. The purpose of this study was to investigate the anti-atopic effects of UMB on 2,4-dinitrochlorobenzene (DNCB)- and house dust mite extract (Dermatophagoides farinae extract, DFE)-treated mice with AD-like skin lesions and on tumor necrosis factor (TNF)-α/interferon (IFN)-γ-treated HaCaT cells. In DNCB/DFE-treated mice, oral administration of UMB (20 and 40 mg/kg) for 28 days led to a significant decrease in ear thickness, spleen size and weight, serum levels of immunoglobulin E (IgE), IgG1, IgG2a, TNF-α, and interleukin 4 (IL-4), and mast cell infiltration; it also led to the suppression of pro-inflammatory cytokines and chemokines. In addition, UMB reduced the secretion of pro-inflammatory cytokines and chemokines in TNF-α/IFN-γ-treated HaCaT cells via regulation of MAPK, IkB-α/NF-κB, and STAT1 signaling pathways. Taken together, these results indicate that UMB ameliorates AD-associated symptoms and inflammation via regulation of various signaling pathways, suggesting that UMB might be a potential therapeutic agent of AD.

Authors+Show Affiliations

Department of Immunology and Institute of Medical Sciences, Medical School, Chonbuk National University, Jeonju, Jeonbuk 54907, Republic of Korea.Department of Immunology and Institute of Medical Sciences, Medical School, Chonbuk National University, Jeonju, Jeonbuk 54907, Republic of Korea.Department of Obstetrics and Gynecology, Chonbuk National University Medical School, Jeonju, Jeonbuk 54907, Republic of Korea.Department of Obstetrics and Gynecology, Chonbuk National University Medical School, Jeonju, Jeonbuk 54907, Republic of Korea. Electronic address: jh.lee@jbnu.ac.kr.Department of Immunology and Institute of Medical Sciences, Medical School, Chonbuk National University, Jeonju, Jeonbuk 54907, Republic of Korea. Electronic address: daekim@jbnu.ac.kr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31437788

Citation

Lim, Ji-Ye, et al. "Umbelliferone Reduces the Expression of Inflammatory Chemokines in HaCaT Cells and DNCB/DFE-induced Atopic Dermatitis Symptoms in Mice." International Immunopharmacology, vol. 75, 2019, p. 105830.
Lim JY, Lee JH, Lee DH, et al. Umbelliferone reduces the expression of inflammatory chemokines in HaCaT cells and DNCB/DFE-induced atopic dermatitis symptoms in mice. Int Immunopharmacol. 2019;75:105830.
Lim, J. Y., Lee, J. H., Lee, D. H., Lee, J. H., & Kim, D. K. (2019). Umbelliferone reduces the expression of inflammatory chemokines in HaCaT cells and DNCB/DFE-induced atopic dermatitis symptoms in mice. International Immunopharmacology, 75, p. 105830. doi:10.1016/j.intimp.2019.105830.
Lim JY, et al. Umbelliferone Reduces the Expression of Inflammatory Chemokines in HaCaT Cells and DNCB/DFE-induced Atopic Dermatitis Symptoms in Mice. Int Immunopharmacol. 2019;75:105830. PubMed PMID: 31437788.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Umbelliferone reduces the expression of inflammatory chemokines in HaCaT cells and DNCB/DFE-induced atopic dermatitis symptoms in mice. AU - Lim,Ji-Ye, AU - Lee,Ji-Hyun, AU - Lee,Dong-Hyun, AU - Lee,Jeong-Heon, AU - Kim,Dae-Ki, Y1 - 2019/08/19/ PY - 2019/05/23/received PY - 2019/08/01/revised PY - 2019/08/12/accepted PY - 2019/8/23/pubmed PY - 2019/8/23/medline PY - 2019/8/23/entrez KW - 2,4-Dinitrochlorobenzene KW - Atopic dermatitis KW - Dermatophagoides farinae extract KW - Umbelliferone, keratinocyte SP - 105830 EP - 105830 JF - International immunopharmacology JO - Int. Immunopharmacol. VL - 75 N2 - Umbelliferone (UMB) is a coumarin derivative present in roots and barks of plants, such as Angelica decursiva, Artemisia capillaris, and orange. UMB has been previously reported to exhibit anti-inflammatory, anti-diabetic, and anti-cancer effects. However, the effect of UMB on atopic dermatitis (AD) remains unknown. The purpose of this study was to investigate the anti-atopic effects of UMB on 2,4-dinitrochlorobenzene (DNCB)- and house dust mite extract (Dermatophagoides farinae extract, DFE)-treated mice with AD-like skin lesions and on tumor necrosis factor (TNF)-α/interferon (IFN)-γ-treated HaCaT cells. In DNCB/DFE-treated mice, oral administration of UMB (20 and 40 mg/kg) for 28 days led to a significant decrease in ear thickness, spleen size and weight, serum levels of immunoglobulin E (IgE), IgG1, IgG2a, TNF-α, and interleukin 4 (IL-4), and mast cell infiltration; it also led to the suppression of pro-inflammatory cytokines and chemokines. In addition, UMB reduced the secretion of pro-inflammatory cytokines and chemokines in TNF-α/IFN-γ-treated HaCaT cells via regulation of MAPK, IkB-α/NF-κB, and STAT1 signaling pathways. Taken together, these results indicate that UMB ameliorates AD-associated symptoms and inflammation via regulation of various signaling pathways, suggesting that UMB might be a potential therapeutic agent of AD. SN - 1878-1705 UR - https://www.unboundmedicine.com/medline/citation/31437788/Umbelliferone_reduces_the_expression_of_inflammatory_chemokines_in_HaCaT_cells_and_DNCB/DFE-induced_atopic_dermatitis_symptoms_in_mice L2 - https://linkinghub.elsevier.com/retrieve/pii/S1567-5769(19)31115-4 DB - PRIME DP - Unbound Medicine ER -