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Thyroid Hormone Distributor Proteins During Development in Vertebrates.

Abstract

Thyroid hormones (THs) are ancient hormones that not only influence the growth, development and metabolism of vertebrates but also affect the metabolism of (at least some) bacteria. Synthesized in the thyroid gland (or follicular cells in fish not having a discrete thyroid gland), THs can act on target cells by genomic or non-genomic mechanisms. Either way, THs need to get from their site of synthesis to their target cells throughout the body. Despite being amphipathic in structure, THs are lipophilic and hence do not freely diffuse in the aqueous environments of blood or cerebrospinal fluid (in contrast to hydrophilic hormones). TH Distributor Proteins (THDPs) have evolved to enable the efficient distribution of THs in the blood and cerebrospinal fluid. In humans, the THDPs are albumin, transthyretin (TTR), and thyroxine-binding globulin (TBG). These three proteins have distinct patterns of regulation in both ontogeny and phylogeny. During development, an additional THDP with higher affinity than those in the adult, is present during the stage of peak TH concentrations in blood. Although TTR is the only THDP synthesized in the central nervous system (CNS), all THDPs from blood are present in the CSF (for each species). However, the ratio of albumin to TTR differs in the CSF compared to the blood. Humans lacking albumin or TBG have been reported and can be asymptomatic, however a human lacking TTR has not been documented. Conversely, there are many diseases either caused by TTR or that have altered levels of TTR in the blood or CSF associated with them. The first world-wide RNAi therapy has just been approved for TTR amyloidosis.

Authors+Show Affiliations

School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.School of Health and Biomedical Sciences, RMIT University, Melbourne, VIC, Australia.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31440205

Citation

Rabah, Sarah A., et al. "Thyroid Hormone Distributor Proteins During Development in Vertebrates." Frontiers in Endocrinology, vol. 10, 2019, p. 506.
Rabah SA, Gowan IL, Pagnin M, et al. Thyroid Hormone Distributor Proteins During Development in Vertebrates. Front Endocrinol (Lausanne). 2019;10:506.
Rabah, S. A., Gowan, I. L., Pagnin, M., Osman, N., & Richardson, S. J. (2019). Thyroid Hormone Distributor Proteins During Development in Vertebrates. Frontiers in Endocrinology, 10, p. 506. doi:10.3389/fendo.2019.00506.
Rabah SA, et al. Thyroid Hormone Distributor Proteins During Development in Vertebrates. Front Endocrinol (Lausanne). 2019;10:506. PubMed PMID: 31440205.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thyroid Hormone Distributor Proteins During Development in Vertebrates. AU - Rabah,Sarah A, AU - Gowan,Indra L, AU - Pagnin,Maurice, AU - Osman,Narin, AU - Richardson,Samantha J, Y1 - 2019/08/08/ PY - 2019/02/14/received PY - 2019/07/11/accepted PY - 2019/8/24/entrez PY - 2019/8/24/pubmed PY - 2019/8/24/medline KW - albumin KW - development KW - evolution KW - phylogeny KW - thyroid hormones KW - thyroxine-binding globulin KW - transthyretin KW - vertebrates SP - 506 EP - 506 JF - Frontiers in endocrinology JO - Front Endocrinol (Lausanne) VL - 10 N2 - Thyroid hormones (THs) are ancient hormones that not only influence the growth, development and metabolism of vertebrates but also affect the metabolism of (at least some) bacteria. Synthesized in the thyroid gland (or follicular cells in fish not having a discrete thyroid gland), THs can act on target cells by genomic or non-genomic mechanisms. Either way, THs need to get from their site of synthesis to their target cells throughout the body. Despite being amphipathic in structure, THs are lipophilic and hence do not freely diffuse in the aqueous environments of blood or cerebrospinal fluid (in contrast to hydrophilic hormones). TH Distributor Proteins (THDPs) have evolved to enable the efficient distribution of THs in the blood and cerebrospinal fluid. In humans, the THDPs are albumin, transthyretin (TTR), and thyroxine-binding globulin (TBG). These three proteins have distinct patterns of regulation in both ontogeny and phylogeny. During development, an additional THDP with higher affinity than those in the adult, is present during the stage of peak TH concentrations in blood. Although TTR is the only THDP synthesized in the central nervous system (CNS), all THDPs from blood are present in the CSF (for each species). However, the ratio of albumin to TTR differs in the CSF compared to the blood. Humans lacking albumin or TBG have been reported and can be asymptomatic, however a human lacking TTR has not been documented. Conversely, there are many diseases either caused by TTR or that have altered levels of TTR in the blood or CSF associated with them. The first world-wide RNAi therapy has just been approved for TTR amyloidosis. SN - 1664-2392 UR - https://www.unboundmedicine.com/medline/citation/31440205/Thyroid_Hormone_Distributor_Proteins_During_Development_in_Vertebrates DB - PRIME DP - Unbound Medicine ER -