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Comparative study on anorexigenic effect of glucagon-like peptide-1 receptor agonists in rats.
Sheng Li Xue Bao 2019; 71(4):514-526SL

Abstract

Glucagon-like peptide-1 (GLP-1) expression is shared by both intestinal cells and neurons of brainstem, which plays anorexigenic role on food intake. However, the exact source of physiological GLP-1 influencing food intake and pertinent mechanism of GLP-1 receptor agonists (GLP-1RA) remain unelucidated. In this study, the immediate early gene product c-Fos was chosen as the specific antigen for immunohistochemistry to show the certain areas of central nervous system (CNS) activation by the GLP-1RA. Thirty normal SD rats were randomly assigned to 3 groups, which were single intraperitoneally injected with Liraglutide (200 μg/kg), Exenatide (10 μg/kg) and saline, respectively. After injection, the amount of food intake and acute glycemic variation were assessed for comparison. The results showed that acute pharmacological dosage of GLP-1RA (Liraglutide or Exenatide) could significantly influence food intake. However, glycemic change indicated that the anorexic effect was dissociated with change in blood glucose in normal rats. Moreover, c-Fos was expressed significantly higher in major critical nuclei related to food intake in GLP-1RA groups when compared with the control group, and its expression was also found in spinal cord. The results suggested that acute administration of pharmacological doses of GLP-1 influences CNS via circulation and vagal pathways, especially on the arcuate nucleus (ARC) and the nucleus of solitary tract (NTS), and GLP-1 modulates autonomic nervous activities.

Authors+Show Affiliations

Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, China.Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, China.Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, China.Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, China.Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, China.Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, China.Department of Endocrinology, Shanghai Pudong Hospital, Fudan University, Shanghai 201399, China. zhouligang@yahoo.com.

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

31440748

Citation

Wen, Song, et al. "Comparative Study On Anorexigenic Effect of Glucagon-like Peptide-1 Receptor Agonists in Rats." Sheng Li Xue Bao : [Acta Physiologica Sinica], vol. 71, no. 4, 2019, pp. 514-526.
Wen S, Nguyen T, Xiao WZ, et al. Comparative study on anorexigenic effect of glucagon-like peptide-1 receptor agonists in rats. Sheng Li Xue Bao. 2019;71(4):514-526.
Wen, S., Nguyen, T., Xiao, W. Z., Wang, C. X., Gong, M., Jin, J. L., & Zhou, L. G. (2019). Comparative study on anorexigenic effect of glucagon-like peptide-1 receptor agonists in rats. Sheng Li Xue Bao : [Acta Physiologica Sinica], 71(4), pp. 514-526.
Wen S, et al. Comparative Study On Anorexigenic Effect of Glucagon-like Peptide-1 Receptor Agonists in Rats. Sheng Li Xue Bao. 2019 Aug 25;71(4):514-526. PubMed PMID: 31440748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative study on anorexigenic effect of glucagon-like peptide-1 receptor agonists in rats. AU - Wen,Song, AU - Nguyen,Thiquynhnga, AU - Xiao,Wen-Ze, AU - Wang,Chao-Xun, AU - Gong,Min, AU - Jin,Jian-Lan, AU - Zhou,Li-Gang, PY - 2019/8/24/entrez PY - 2019/8/24/pubmed PY - 2019/9/27/medline SP - 514 EP - 526 JF - Sheng li xue bao : [Acta physiologica Sinica] JO - Sheng Li Xue Bao VL - 71 IS - 4 N2 - Glucagon-like peptide-1 (GLP-1) expression is shared by both intestinal cells and neurons of brainstem, which plays anorexigenic role on food intake. However, the exact source of physiological GLP-1 influencing food intake and pertinent mechanism of GLP-1 receptor agonists (GLP-1RA) remain unelucidated. In this study, the immediate early gene product c-Fos was chosen as the specific antigen for immunohistochemistry to show the certain areas of central nervous system (CNS) activation by the GLP-1RA. Thirty normal SD rats were randomly assigned to 3 groups, which were single intraperitoneally injected with Liraglutide (200 μg/kg), Exenatide (10 μg/kg) and saline, respectively. After injection, the amount of food intake and acute glycemic variation were assessed for comparison. The results showed that acute pharmacological dosage of GLP-1RA (Liraglutide or Exenatide) could significantly influence food intake. However, glycemic change indicated that the anorexic effect was dissociated with change in blood glucose in normal rats. Moreover, c-Fos was expressed significantly higher in major critical nuclei related to food intake in GLP-1RA groups when compared with the control group, and its expression was also found in spinal cord. The results suggested that acute administration of pharmacological doses of GLP-1 influences CNS via circulation and vagal pathways, especially on the arcuate nucleus (ARC) and the nucleus of solitary tract (NTS), and GLP-1 modulates autonomic nervous activities. SN - 0371-0874 UR - https://www.unboundmedicine.com/medline/citation/31440748/Comparative_study_on_anorexigenic_effect_of_glucagon-like_peptide-1_receptor_agonists_in_rats DB - PRIME DP - Unbound Medicine ER -