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Untreated adult GH deficiency is not associated with the development of metabolic risk factors: a long-term observational study.

Abstract

PURPOSE

Uncertainties exist about the predictors of the severity of the clinical picture of GH deficiency (GHD) syndrome. Aim of the study was to evaluate, in adult patients with GHD, the predictors of the development of hypercholesterolemia, hypertension, diabetes mellitus, and osteoporosis.

METHODS

We retrospectively studied 327 adult patients (age 47.1 ± 17.1 years) with untreated severe GHD (mean follow-up 110.9 ± 56.8 months). GHD was defined by GHRH + arginine test using BMI cut-offs. The possible development of hypercholesterolemia, hypertension, diabetes mellitus, and osteoporosis was investigated by Kaplan-Meier survival analysis. For each clinical outcome, either a univariate or multivariate analysis according to the Cox proportional-hazards model was performed to identify those factors that were associated with the development of the event.

RESULTS

GH secretion parameters were not associated with the outcomes. Hypercholesterolemia was positively and negatively predicted by a BMI ≥ 30 kg/m2 (HR 2.50, p 0.00) and the dose of l-thyroxine possibly in place (HR 0.98, p 0.02), respectively. Hypertension was positively predicted by a BMI ≥ 30 kg/m2 (HR 2.64, p 0.00) and IGF-I SDS values (HR 2.26, p 0.00). Diabetes mellitus was positively predicted by hypertension (HR 11.76, p 0.01). Osteoporosis was positively and negatively predicted by hypercholesterolemia (HR 3.25, p 0.01) and hypertension (HR 0.21, p 0.00), respectively.

CONCLUSIONS

The severity of the impairment of GH secretion does not predict the development of the clinical picture of GHD syndrome: untreated adult GHD does not increase the development of metabolic risk factors in hypopituitaric patients.

Authors+Show Affiliations

Division of Endocrinology, Diabetes and Metabolism, Department of Medical Science, University of Turin, Turin, Italy. valentina.gasco@unito.it.Division of Endocrinology, Diabetes and Metabolism, Department of Medical Science, University of Turin, Turin, Italy.Division of Endocrinology, Diabetes and Metabolism, Department of Medical Science, University of Turin, Turin, Italy.Division of Endocrinology, Diabetes and Metabolism, Department of Medical Science, University of Turin, Turin, Italy.Division of Endocrinology, Diabetes and Metabolism, Department of Medical Science, University of Turin, Turin, Italy.Division of Endocrinology, Diabetes and Metabolism, Department of Medical Science, University of Turin, Turin, Italy.Division of Endocrinology, Diabetes and Metabolism, Department of Medical Science, University of Turin, Turin, Italy.Division of Endocrinology, Diabetes and Metabolism, Department of Medical Science, University of Turin, Turin, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31440920

Citation

Gasco, V, et al. "Untreated Adult GH Deficiency Is Not Associated With the Development of Metabolic Risk Factors: a Long-term Observational Study." Journal of Endocrinological Investigation, 2019.
Gasco V, Roncoroni L, Zavattaro M, et al. Untreated adult GH deficiency is not associated with the development of metabolic risk factors: a long-term observational study. J Endocrinol Invest. 2019.
Gasco, V., Roncoroni, L., Zavattaro, M., Bona, C., Berton, A., Ghigo, E., ... Grottoli, S. (2019). Untreated adult GH deficiency is not associated with the development of metabolic risk factors: a long-term observational study. Journal of Endocrinological Investigation, doi:10.1007/s40618-019-01100-y.
Gasco V, et al. Untreated Adult GH Deficiency Is Not Associated With the Development of Metabolic Risk Factors: a Long-term Observational Study. J Endocrinol Invest. 2019 Aug 22; PubMed PMID: 31440920.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Untreated adult GH deficiency is not associated with the development of metabolic risk factors: a long-term observational study. AU - Gasco,V, AU - Roncoroni,L, AU - Zavattaro,M, AU - Bona,C, AU - Berton,A, AU - Ghigo,E, AU - Maccario,M, AU - Grottoli,S, Y1 - 2019/08/22/ PY - 2019/07/13/received PY - 2019/08/13/accepted PY - 2019/8/24/entrez KW - Diabetes mellitus KW - GH deficiency syndrome KW - Hypercholesterolemia KW - Hypertension KW - Osteoporosis KW - Predictors JF - Journal of endocrinological investigation JO - J. Endocrinol. Invest. N2 - PURPOSE: Uncertainties exist about the predictors of the severity of the clinical picture of GH deficiency (GHD) syndrome. Aim of the study was to evaluate, in adult patients with GHD, the predictors of the development of hypercholesterolemia, hypertension, diabetes mellitus, and osteoporosis. METHODS: We retrospectively studied 327 adult patients (age 47.1 ± 17.1 years) with untreated severe GHD (mean follow-up 110.9 ± 56.8 months). GHD was defined by GHRH + arginine test using BMI cut-offs. The possible development of hypercholesterolemia, hypertension, diabetes mellitus, and osteoporosis was investigated by Kaplan-Meier survival analysis. For each clinical outcome, either a univariate or multivariate analysis according to the Cox proportional-hazards model was performed to identify those factors that were associated with the development of the event. RESULTS: GH secretion parameters were not associated with the outcomes. Hypercholesterolemia was positively and negatively predicted by a BMI ≥ 30 kg/m2 (HR 2.50, p 0.00) and the dose of l-thyroxine possibly in place (HR 0.98, p 0.02), respectively. Hypertension was positively predicted by a BMI ≥ 30 kg/m2 (HR 2.64, p 0.00) and IGF-I SDS values (HR 2.26, p 0.00). Diabetes mellitus was positively predicted by hypertension (HR 11.76, p 0.01). Osteoporosis was positively and negatively predicted by hypercholesterolemia (HR 3.25, p 0.01) and hypertension (HR 0.21, p 0.00), respectively. CONCLUSIONS: The severity of the impairment of GH secretion does not predict the development of the clinical picture of GHD syndrome: untreated adult GHD does not increase the development of metabolic risk factors in hypopituitaric patients. SN - 1720-8386 UR - https://www.unboundmedicine.com/medline/citation/31440920/Untreated_adult_GH_deficiency_is_not_associated_with_the_development_of_metabolic_risk_factors:_a_long-term_observational_study L2 - https://link.springer.com/article/10.1007/s40618-019-01100-y DB - PRIME DP - Unbound Medicine ER -