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High exposure to statins decrease the risk of new-onset dementia: A nationwide population-based longitudinal cohort study.
Medicine (Baltimore). 2019 Aug; 98(34):e16931.M

Abstract

Several studies have shown that statin users have a lower risk of new-onset dementia (NOD) compared nonusers. However, other studies have shown opposite results. In this study, we investigated the association between the use of statins and the development of NOD.This was a longitudinal cohort study using data from claim forms submitted to the Taiwanese Bureau of National Health Insurance. The study included patients with NOD and non-NOD subjects from January 2002 to December 2013. We estimated the hazard ratios (HRs) of NOD associated with statin use, whereas nonuser subjects were used as a reference group.A total of 19,522 NOD cases were identified in 100,610 hyperlipidemic patients during the study period. The risk of NOD, after adjusting for sex, age, comorbidities, and concurrent medication, was lower among statin users than nonusers (HR 0.95, 95% CI [confidence interval] 0.94-0.96; P < .001). The adjusted HRs for NOD were 1.53 (95% CI, 1.45-1.62), 0.63 (95% CI, 0.57-0.71), and 0.34 (95% CI, 0.30-0.38) when the cumulative defined daily doses ranged from 28 to 365, 366 to 730, and more than 730 relative to nonusers, respectively.We concluded that statin use is associated with a decreased NOD risk. The protective effect of statins for NOD seemed to be related to high exposure to statins. This study also highlights that high exposure to statins has a dose-response effect on lowering NOD risk.

Authors+Show Affiliations

Division of Cardiology, Department of Internal Medicine, Armed Force Taichung General Hospital, and National Defense Medical Center,Taichung.Department of Family Medicine, Taichung Veteran General Hospital, and School of Public Health, National Defense Medical Center, Taipei.Armed Forces Medical Supplies Office, Medical Affairs Bureau, Taoyuan, Taiwan, ROC.University of California, San Diego, La Jolla, CA.Division of Nutrition, Chia Nan University of Pharmacy and Science, Tainan.Institute of Pharmacy, China Medical University.Division of Internal Cardiology, Chung Shan Medical University Hospital and Chung Shan Medical University, Taichung, Taiwan, ROC.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

31441882

Citation

Chang, Chih-Feng, et al. "High Exposure to Statins Decrease the Risk of New-onset Dementia: a Nationwide Population-based Longitudinal Cohort Study." Medicine, vol. 98, no. 34, 2019, pp. e16931.
Chang CF, Liou YS, Lin TK, et al. High exposure to statins decrease the risk of new-onset dementia: A nationwide population-based longitudinal cohort study. Medicine (Baltimore). 2019;98(34):e16931.
Chang, C. F., Liou, Y. S., Lin, T. K., Ma, S., Hu, Y. R., Chen, H. Y., & Jong, G. P. (2019). High exposure to statins decrease the risk of new-onset dementia: A nationwide population-based longitudinal cohort study. Medicine, 98(34), e16931. https://doi.org/10.1097/MD.0000000000016931
Chang CF, et al. High Exposure to Statins Decrease the Risk of New-onset Dementia: a Nationwide Population-based Longitudinal Cohort Study. Medicine (Baltimore). 2019;98(34):e16931. PubMed PMID: 31441882.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - High exposure to statins decrease the risk of new-onset dementia: A nationwide population-based longitudinal cohort study. AU - Chang,Chih-Feng, AU - Liou,Yi-Sheng, AU - Lin,Tsung-Kun, AU - Ma,Stacey, AU - Hu,Yu-Ru, AU - Chen,Hung-Yi, AU - Jong,Gwo-Ping, PY - 2019/8/24/entrez PY - 2019/8/24/pubmed PY - 2019/9/4/medline SP - e16931 EP - e16931 JF - Medicine JO - Medicine (Baltimore) VL - 98 IS - 34 N2 - Several studies have shown that statin users have a lower risk of new-onset dementia (NOD) compared nonusers. However, other studies have shown opposite results. In this study, we investigated the association between the use of statins and the development of NOD.This was a longitudinal cohort study using data from claim forms submitted to the Taiwanese Bureau of National Health Insurance. The study included patients with NOD and non-NOD subjects from January 2002 to December 2013. We estimated the hazard ratios (HRs) of NOD associated with statin use, whereas nonuser subjects were used as a reference group.A total of 19,522 NOD cases were identified in 100,610 hyperlipidemic patients during the study period. The risk of NOD, after adjusting for sex, age, comorbidities, and concurrent medication, was lower among statin users than nonusers (HR 0.95, 95% CI [confidence interval] 0.94-0.96; P < .001). The adjusted HRs for NOD were 1.53 (95% CI, 1.45-1.62), 0.63 (95% CI, 0.57-0.71), and 0.34 (95% CI, 0.30-0.38) when the cumulative defined daily doses ranged from 28 to 365, 366 to 730, and more than 730 relative to nonusers, respectively.We concluded that statin use is associated with a decreased NOD risk. The protective effect of statins for NOD seemed to be related to high exposure to statins. This study also highlights that high exposure to statins has a dose-response effect on lowering NOD risk. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/31441882/High_exposure_to_statins_decrease_the_risk_of_new_onset_dementia:_A_nationwide_population_based_longitudinal_cohort_study_ L2 - http://dx.doi.org/10.1097/MD.0000000000016931 DB - PRIME DP - Unbound Medicine ER -