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Efficacy and safety of Chinese medicines for asthma: A systematic review protocol.
Medicine (Baltimore) 2019; 98(34):e16958M

Abstract

BACKGROUND

Asthma is a complex disease associated with many factors such as immunologic, environmental, genetic, and other factors. Common medicines used to treat asthma include β-agonist and glucocorticoid. However, in the long-term treatment, the effect of the above-mentioned drugs is not satisfactory, so many patients choose oral Chinese medicines instead of western medicines. The introduction of Chinese medicines therapies, a rapid proliferation of the literature on management of asthma in general, call for novel ways of evidence synthesis in this area. This systematic review is to systematically summarize and evaluate a large number of evidences for Chinese herbal interventions for asthma. Evaluate the efficacy and safety of Chinese medicines in the treatment of asthma and inform a decision aid for the clinical encounter between patients and clinicians. In addition, it helps to establish a future research agenda.

METHODS

Five English databases (PubMed, Web of science, EBASE, Springer Cochrane Library, and WHO International Clinical Trials Registry Platform) and 4 Chinese databases (Wanfang Database, Chinese Scientific Journal Database, China National Knowledge Infrastructure Database, and Chinese Biomedical Literature Database) will be searched normatively according to the rule of each database from the inception to the present. The literature screening, data extraction, and quality assessment will be conducted by 2 researchers independently. Data will be synthesized by either the fixed-effects or random-effects model according to a heterogeneity test. Asthma control test symptom score will be assessed as the primary outcome. The curative effect of single symptom and sign; Withdrawal and reduction of western medicines in a course of treatment, including: time, type, and quantity; Maintenance of western medicines after the course of treatment, including: type, quantity; Asthma Quality of Life Questionnaire; laboratory efficacy indexes as the secondary outcome. General physical examination; routine examination of blood, urine, and stool; electrocardiogram; liver and kidney function examination; possible adverse reactions and related detection indicators as the security indexes. Meta-analysis will be performed using RevMan5.3.5 software provided by the Cochrane Collaboration.

RESULTS

This study will provide high-quality synthesis based on current evidence of Chinese medicines treatment for asthma in several aspects, including asthma control score, side effects and laboratory examination such as lung-function test, serum total immunoglobulin, and so on.

CONCLUSION

The results of this study will provide updated evidence for whether Chinese medicines is an effective and safe intervention for asthma.

PROSPERO REGISTRATION NUMBER

PROSPERO CRD42019136074.

Authors+Show Affiliations

The 2nd Department of Pulmonary Disease in TCM, The Key Unit of SATCM Pneumonopathy Chronic Cough and Dyspnea, Beijing Key Laboratory of Prevention and Treatment of Allergic Diseases with TCM (No. BZ0321), Center of Respiratory Medicine, China-Japan Friendship Hospital, National Clinical Research Center for Respiratory Diseases.Beijing University of Chinese Medicine, Beijing.Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine, Hohhot, China.The 2nd Department of Pulmonary Disease in TCM, The Key Unit of SATCM Pneumonopathy Chronic Cough and Dyspnea, Beijing Key Laboratory of Prevention and Treatment of Allergic Diseases with TCM (No. BZ0321), Center of Respiratory Medicine, China-Japan Friendship Hospital, National Clinical Research Center for Respiratory Diseases.The 2nd Department of Pulmonary Disease in TCM, The Key Unit of SATCM Pneumonopathy Chronic Cough and Dyspnea, Beijing Key Laboratory of Prevention and Treatment of Allergic Diseases with TCM (No. BZ0321), Center of Respiratory Medicine, China-Japan Friendship Hospital, National Clinical Research Center for Respiratory Diseases.The 2nd Department of Pulmonary Disease in TCM, The Key Unit of SATCM Pneumonopathy Chronic Cough and Dyspnea, Beijing Key Laboratory of Prevention and Treatment of Allergic Diseases with TCM (No. BZ0321), Center of Respiratory Medicine, China-Japan Friendship Hospital, National Clinical Research Center for Respiratory Diseases.Beijing University of Chinese Medicine, Beijing.Beijing University of Chinese Medicine, Beijing.Beijing University of Chinese Medicine, Beijing.The 2nd Department of Pulmonary Disease in TCM, The Key Unit of SATCM Pneumonopathy Chronic Cough and Dyspnea, Beijing Key Laboratory of Prevention and Treatment of Allergic Diseases with TCM (No. BZ0321), Center of Respiratory Medicine, China-Japan Friendship Hospital, National Clinical Research Center for Respiratory Diseases.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31441897

Citation

Shi, Qi, et al. "Efficacy and Safety of Chinese Medicines for Asthma: a Systematic Review Protocol." Medicine, vol. 98, no. 34, 2019, pp. e16958.
Shi Q, Si D, Bao H, et al. Efficacy and safety of Chinese medicines for asthma: A systematic review protocol. Medicine (Baltimore). 2019;98(34):e16958.
Shi, Q., Si, D., Bao, H., Yan, Y., Kong, Y., Li, C., ... Li, Y. (2019). Efficacy and safety of Chinese medicines for asthma: A systematic review protocol. Medicine, 98(34), pp. e16958. doi:10.1097/MD.0000000000016958.
Shi Q, et al. Efficacy and Safety of Chinese Medicines for Asthma: a Systematic Review Protocol. Medicine (Baltimore). 2019;98(34):e16958. PubMed PMID: 31441897.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy and safety of Chinese medicines for asthma: A systematic review protocol. AU - Shi,Qi, AU - Si,Dongxu, AU - Bao,Haipeng, AU - Yan,Yue, AU - Kong,Yanhua, AU - Li,Chunlei, AU - He,Wenfeng, AU - Damchaaperenlei,Dashzeveg, AU - Yu,Mingxia, AU - Li,Youlin, PY - 2019/8/24/entrez PY - 2019/8/24/pubmed PY - 2019/9/4/medline SP - e16958 EP - e16958 JF - Medicine JO - Medicine (Baltimore) VL - 98 IS - 34 N2 - BACKGROUND: Asthma is a complex disease associated with many factors such as immunologic, environmental, genetic, and other factors. Common medicines used to treat asthma include β-agonist and glucocorticoid. However, in the long-term treatment, the effect of the above-mentioned drugs is not satisfactory, so many patients choose oral Chinese medicines instead of western medicines. The introduction of Chinese medicines therapies, a rapid proliferation of the literature on management of asthma in general, call for novel ways of evidence synthesis in this area. This systematic review is to systematically summarize and evaluate a large number of evidences for Chinese herbal interventions for asthma. Evaluate the efficacy and safety of Chinese medicines in the treatment of asthma and inform a decision aid for the clinical encounter between patients and clinicians. In addition, it helps to establish a future research agenda. METHODS: Five English databases (PubMed, Web of science, EBASE, Springer Cochrane Library, and WHO International Clinical Trials Registry Platform) and 4 Chinese databases (Wanfang Database, Chinese Scientific Journal Database, China National Knowledge Infrastructure Database, and Chinese Biomedical Literature Database) will be searched normatively according to the rule of each database from the inception to the present. The literature screening, data extraction, and quality assessment will be conducted by 2 researchers independently. Data will be synthesized by either the fixed-effects or random-effects model according to a heterogeneity test. Asthma control test symptom score will be assessed as the primary outcome. The curative effect of single symptom and sign; Withdrawal and reduction of western medicines in a course of treatment, including: time, type, and quantity; Maintenance of western medicines after the course of treatment, including: type, quantity; Asthma Quality of Life Questionnaire; laboratory efficacy indexes as the secondary outcome. General physical examination; routine examination of blood, urine, and stool; electrocardiogram; liver and kidney function examination; possible adverse reactions and related detection indicators as the security indexes. Meta-analysis will be performed using RevMan5.3.5 software provided by the Cochrane Collaboration. RESULTS: This study will provide high-quality synthesis based on current evidence of Chinese medicines treatment for asthma in several aspects, including asthma control score, side effects and laboratory examination such as lung-function test, serum total immunoglobulin, and so on. CONCLUSION: The results of this study will provide updated evidence for whether Chinese medicines is an effective and safe intervention for asthma. PROSPERO REGISTRATION NUMBER: PROSPERO CRD42019136074. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/31441897/Efficacy_and_safety_of_Chinese_medicines_for_asthma:_A_systematic_review_protocol L2 - http://Insights.ovid.com/pubmed?pmid=31441897 DB - PRIME DP - Unbound Medicine ER -