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Rutin ameliorates mercuric chloride-induced hepatotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis.
J Trace Elem Med Biol 2019; 56:60-68JT

Abstract

OBJECTIVE

Mercury is a global environmental pollutant and is responsible for several organ pathophysiology including oxidative stress-induced liver disorders. Therefore, the present study was conducted to evaluate the potential ameliorative effects of rutin on mercury chloride (HgCl2)-induced hepatotoxicity in adult male rats.

METHODS

HgCl2 was intraperitoneally injected at a dose of 1.23 mg/kg body weight for 7 days alone or in combination with the orally rutin (50 and 100 mg/kg body weight).

RESULTS

Rutin treatment significantly improved liver function tests [alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT)], and increased activities of antioxidant defense system [catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx)] and glutathione (GSH) content. The histological alterations and epidermal growth factor receptor (EGFR) expression in the HgCl2-induced liver tissues were decreased by administration of rutin. Furthermore, rutin reversed the changes in levels of apoptosis and inflammation related proteins involving p53, Bcl-2 associated X protein (Bax), B-cell lymphoma-2 (Bcl-2), cytochrome c, nuclear factor kappa B (NF-κB), tumor necrosis factor-α (TNF-α), B-cell lymphoma-3(Bcl-3) and interleukin-1β (IL-1β), and inhibited p38α mitogen-activated protein kinase (MAPK) and cysteine aspartate specific protease-3 (caspase-3) activations.

CONCLUSION

The data of the present study suggest that rutin effectively suppress HgCl2-induced hepatotoxicity by ameliorating oxidative stress, inflammation and apoptosis.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Veterinary Medicine, Bingol University, Bingol, 12000, Turkey. Electronic address: ccaglayan@bingol.edu.tr.Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey.Department of Molecular Biology and Genetics, Faculty of Science and Literature, Bingol University, Bingol, Turkey.Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey.Department of Biochemistry, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey.Department of Pathology, Faculty of Veterinary Medicine, Ataturk University, Erzurum, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31442956

Citation

Caglayan, Cuneyt, et al. "Rutin Ameliorates Mercuric Chloride-induced Hepatotoxicity in Rats Via Interfering With Oxidative Stress, Inflammation and Apoptosis." Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), vol. 56, 2019, pp. 60-68.
Caglayan C, Kandemir FM, Darendelioğlu E, et al. Rutin ameliorates mercuric chloride-induced hepatotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis. J Trace Elem Med Biol. 2019;56:60-68.
Caglayan, C., Kandemir, F. M., Darendelioğlu, E., Yıldırım, S., Kucukler, S., & Dortbudak, M. B. (2019). Rutin ameliorates mercuric chloride-induced hepatotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis. Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), 56, pp. 60-68. doi:10.1016/j.jtemb.2019.07.011.
Caglayan C, et al. Rutin Ameliorates Mercuric Chloride-induced Hepatotoxicity in Rats Via Interfering With Oxidative Stress, Inflammation and Apoptosis. J Trace Elem Med Biol. 2019;56:60-68. PubMed PMID: 31442956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Rutin ameliorates mercuric chloride-induced hepatotoxicity in rats via interfering with oxidative stress, inflammation and apoptosis. AU - Caglayan,Cuneyt, AU - Kandemir,Fatih Mehmet, AU - Darendelioğlu,Ekrem, AU - Yıldırım,Serkan, AU - Kucukler,Sefa, AU - Dortbudak,Muhammet Bahaeddin, Y1 - 2019/08/01/ PY - 2019/06/27/received PY - 2019/07/30/revised PY - 2019/07/31/accepted PY - 2019/8/24/pubmed PY - 2019/8/24/medline PY - 2019/8/24/entrez KW - Apoptosis KW - Epidermal growth factor receptor KW - Hepatotoxicity KW - Inflammation KW - Mercuric chloride KW - Rutin SP - 60 EP - 68 JF - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) JO - J Trace Elem Med Biol VL - 56 N2 - OBJECTIVE: Mercury is a global environmental pollutant and is responsible for several organ pathophysiology including oxidative stress-induced liver disorders. Therefore, the present study was conducted to evaluate the potential ameliorative effects of rutin on mercury chloride (HgCl2)-induced hepatotoxicity in adult male rats. METHODS: HgCl2 was intraperitoneally injected at a dose of 1.23 mg/kg body weight for 7 days alone or in combination with the orally rutin (50 and 100 mg/kg body weight). RESULTS: Rutin treatment significantly improved liver function tests [alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT)], and increased activities of antioxidant defense system [catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx)] and glutathione (GSH) content. The histological alterations and epidermal growth factor receptor (EGFR) expression in the HgCl2-induced liver tissues were decreased by administration of rutin. Furthermore, rutin reversed the changes in levels of apoptosis and inflammation related proteins involving p53, Bcl-2 associated X protein (Bax), B-cell lymphoma-2 (Bcl-2), cytochrome c, nuclear factor kappa B (NF-κB), tumor necrosis factor-α (TNF-α), B-cell lymphoma-3(Bcl-3) and interleukin-1β (IL-1β), and inhibited p38α mitogen-activated protein kinase (MAPK) and cysteine aspartate specific protease-3 (caspase-3) activations. CONCLUSION: The data of the present study suggest that rutin effectively suppress HgCl2-induced hepatotoxicity by ameliorating oxidative stress, inflammation and apoptosis. SN - 1878-3252 UR - https://www.unboundmedicine.com/medline/citation/31442956/Rutin_ameliorates_mercuric_chloride-induced_hepatotoxicity_in_rats_via_interfering_with_oxidative_stress,_inflammation_and_apoptosis L2 - https://linkinghub.elsevier.com/retrieve/pii/S0946-672X(19)30425-0 DB - PRIME DP - Unbound Medicine ER -