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Native Hypovitaminosis D in CKD Patients: From Experimental Evidence to Clinical Practice.
Nutrients. 2019 Aug 15; 11(8)N

Abstract

Native hypovitaminosis D (n-hVITD) is frequently found from the early stages of chronic kidney disease (CKD) and its prevalence increases with CKD progression. Even if the implications of n-hVITD in chronic kidney disease-mineral bone disorder (CKD-MBD) have been extensively characterized in the literature, there is a lot of debate nowadays about the so called "unconventional effects" of native vitamin D (25(OH)VitD) supplementation in CKD patients. In this review, highlights of the dimension of the problem of n-hVITD in CKD stages 2-5 ND patients will be presented. In addition, it will focus on the "unconventional effects" of 25(OH)VitD supplementation, the clinical impact of n-hVITD and the most significant interventional studies regarding 25(OH)VitD supplementation in CKD stages 2-5 ND.

Authors+Show Affiliations

Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy.Department of Internal Medicine n3, Ternopil State Medical University, 46002 Ternopil, Ukraine.Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy.Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy. Renal Division, ASST Santi Paolo e Carlo, Department of Health Sciences, University of Milan, 20122 Milan, Italy.Nephrology, Dialysis and Renal Transplantation, Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. piergiorgio.messa@unimi.it. Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy. piergiorgio.messa@unimi.it.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31443249

Citation

Alfieri, Carlo, et al. "Native Hypovitaminosis D in CKD Patients: From Experimental Evidence to Clinical Practice." Nutrients, vol. 11, no. 8, 2019.
Alfieri C, Ruzhytska O, Vettoretti S, et al. Native Hypovitaminosis D in CKD Patients: From Experimental Evidence to Clinical Practice. Nutrients. 2019;11(8).
Alfieri, C., Ruzhytska, O., Vettoretti, S., Caldiroli, L., Cozzolino, M., & Messa, P. (2019). Native Hypovitaminosis D in CKD Patients: From Experimental Evidence to Clinical Practice. Nutrients, 11(8). https://doi.org/10.3390/nu11081918
Alfieri C, et al. Native Hypovitaminosis D in CKD Patients: From Experimental Evidence to Clinical Practice. Nutrients. 2019 Aug 15;11(8) PubMed PMID: 31443249.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Native Hypovitaminosis D in CKD Patients: From Experimental Evidence to Clinical Practice. AU - Alfieri,Carlo, AU - Ruzhytska,Oksana, AU - Vettoretti,Simone, AU - Caldiroli,Lara, AU - Cozzolino,Mario, AU - Messa,Piergiorgio, Y1 - 2019/08/15/ PY - 2019/07/05/received PY - 2019/08/07/revised PY - 2019/08/12/accepted PY - 2019/8/25/entrez PY - 2019/8/25/pubmed PY - 2020/2/11/medline KW - CKD KW - cardiovascular risk KW - mineral metabolism KW - vitamin D KW - vitamin D supplementation JF - Nutrients JO - Nutrients VL - 11 IS - 8 N2 - Native hypovitaminosis D (n-hVITD) is frequently found from the early stages of chronic kidney disease (CKD) and its prevalence increases with CKD progression. Even if the implications of n-hVITD in chronic kidney disease-mineral bone disorder (CKD-MBD) have been extensively characterized in the literature, there is a lot of debate nowadays about the so called "unconventional effects" of native vitamin D (25(OH)VitD) supplementation in CKD patients. In this review, highlights of the dimension of the problem of n-hVITD in CKD stages 2-5 ND patients will be presented. In addition, it will focus on the "unconventional effects" of 25(OH)VitD supplementation, the clinical impact of n-hVITD and the most significant interventional studies regarding 25(OH)VitD supplementation in CKD stages 2-5 ND. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/31443249/Native_Hypovitaminosis_D_in_CKD_Patients:_From_Experimental_Evidence_to_Clinical_Practice_ L2 - https://www.mdpi.com/resolver?pii=nu11081918 DB - PRIME DP - Unbound Medicine ER -