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Thyroid hormone levels associate with exposure to polychlorinated biphenyls and polybrominated biphenyls in adults exposed as children.
Environ Health 2019; 18(1):75EH

Abstract

BACKGROUND

Michigan residents were directly exposed to endocrine-disrupting compounds, polybrominated biphenyl (PBB) and polychlorinated biphenyl (PCB). A growing body of evidence suggests that exposure to certain endocrine-disrupting compounds may affect thyroid function, especially in people exposed as children, but there are conflicting observations. In this study, we extend previous work by examining age of exposure's effect on the relationship between PBB exposure and thyroid function in a large group of individuals exposed to PBB.

METHODS

Linear regression models were used to test the association between serum measures of thyroid function (total thyroxine (T4), total triiodothyronine (T3), free T4, free T3, thyroid stimulating hormone (TSH), and free T3: free T4 ratio) and serum PBB and PCB levels in a cross-sectional analysis of 715 participants in the Michigan PBB Registry.

RESULTS

Higher PBB levels were associated with many thyroid hormones measures, including higher free T3 (p = 0.002), lower free T4 (p = 0.01), and higher free T3: free T4 ratio (p = 0.0001). Higher PCB levels were associated with higher free T4 (p = 0.0002), and higher free T3: free T4 ratio (p = 0.002). Importantly, the association between PBB and thyroid hormones was dependent on age at exposure. Among people exposed before age 16 (N = 446), higher PBB exposure was associated with higher total T3 (p = 0.01) and free T3 (p = 0.0003), lower free T4 (p = 0.04), and higher free T3: free T4 ratio (p = 0.0001). No significant associations were found among participants who were exposed after age 16. No significant associations were found between TSH and PBB or PCB in any of the analyses conducted.

CONCLUSIONS

This suggests that both PBB and PCB are associated with thyroid function, particularly among those who were exposed as children or prenatally.

Authors+Show Affiliations

Emory University School of Medicine, 101 Woodruff Circle NE, Ste 2205A, Atlanta, GA, 30322, USA.Emory University Rollins School of Public Health, 1518 Clifton Rd, Atlanta, GA, 30322, USA.Emory University Rollins School of Public Health, 1518 Clifton Rd, Atlanta, GA, 30322, USA.Emory University School of Medicine, 101 Woodruff Circle NE, Ste 2205A, Atlanta, GA, 30322, USA.Emory University School of Medicine, 101 Woodruff Circle NE, Ste 2205A, Atlanta, GA, 30322, USA.Emory University School of Medicine, 101 Woodruff Circle NE, Ste 2205A, Atlanta, GA, 30322, USA.Emory University School of Medicine, 101 Woodruff Circle NE, Ste 2205A, Atlanta, GA, 30322, USA.Emory University School of Medicine, 101 Woodruff Circle NE, Ste 2205A, Atlanta, GA, 30322, USA.Emory University Rollins School of Public Health, 1518 Clifton Rd, Atlanta, GA, 30322, USA.Emory University Rollins School of Public Health, 1518 Clifton Rd, Atlanta, GA, 30322, USA.Emory University School of Medicine, 615 Michael St, Atlanta, GA, 30322, USA.Emory University School of Medicine, 101 Woodruff Circle NE, Ste 2205A, Atlanta, GA, 30322, USA. alicia.smith@emory.edu.Emory University Rollins School of Public Health, 1518 Clifton Rd, Atlanta, GA, 30322, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31443693

Citation

Curtis, Sarah W., et al. "Thyroid Hormone Levels Associate With Exposure to Polychlorinated Biphenyls and Polybrominated Biphenyls in Adults Exposed as Children." Environmental Health : a Global Access Science Source, vol. 18, no. 1, 2019, p. 75.
Curtis SW, Terrell ML, Jacobson MH, et al. Thyroid hormone levels associate with exposure to polychlorinated biphenyls and polybrominated biphenyls in adults exposed as children. Environ Health. 2019;18(1):75.
Curtis, S. W., Terrell, M. L., Jacobson, M. H., Cobb, D. O., Jiang, V. S., Neblett, M. F., ... Marcus, M. (2019). Thyroid hormone levels associate with exposure to polychlorinated biphenyls and polybrominated biphenyls in adults exposed as children. Environmental Health : a Global Access Science Source, 18(1), p. 75. doi:10.1186/s12940-019-0509-z.
Curtis SW, et al. Thyroid Hormone Levels Associate With Exposure to Polychlorinated Biphenyls and Polybrominated Biphenyls in Adults Exposed as Children. Environ Health. 2019 Aug 23;18(1):75. PubMed PMID: 31443693.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Thyroid hormone levels associate with exposure to polychlorinated biphenyls and polybrominated biphenyls in adults exposed as children. AU - Curtis,Sarah W, AU - Terrell,Metrecia L, AU - Jacobson,Melanie H, AU - Cobb,Dawayland O, AU - Jiang,Victoria S, AU - Neblett,Michael F, AU - Gerkowicz,Sabrina A, AU - Spencer,Jessica B, AU - Marder,M Elizabeth, AU - Barr,Dana Boyd, AU - Conneely,Karen N, AU - Smith,Alicia K, AU - Marcus,Michele, Y1 - 2019/08/23/ PY - 2018/12/17/received PY - 2019/07/30/accepted PY - 2019/8/25/entrez PY - 2019/8/25/pubmed PY - 2019/8/25/medline KW - Age at exposure KW - Children’s health KW - DOHaD KW - EDC KW - Endocrine disrupting compound KW - PBB KW - PCB KW - Thyroid-stimulating hormone KW - Thyroxine KW - Triiodothyronine SP - 75 EP - 75 JF - Environmental health : a global access science source JO - Environ Health VL - 18 IS - 1 N2 - BACKGROUND: Michigan residents were directly exposed to endocrine-disrupting compounds, polybrominated biphenyl (PBB) and polychlorinated biphenyl (PCB). A growing body of evidence suggests that exposure to certain endocrine-disrupting compounds may affect thyroid function, especially in people exposed as children, but there are conflicting observations. In this study, we extend previous work by examining age of exposure's effect on the relationship between PBB exposure and thyroid function in a large group of individuals exposed to PBB. METHODS: Linear regression models were used to test the association between serum measures of thyroid function (total thyroxine (T4), total triiodothyronine (T3), free T4, free T3, thyroid stimulating hormone (TSH), and free T3: free T4 ratio) and serum PBB and PCB levels in a cross-sectional analysis of 715 participants in the Michigan PBB Registry. RESULTS: Higher PBB levels were associated with many thyroid hormones measures, including higher free T3 (p = 0.002), lower free T4 (p = 0.01), and higher free T3: free T4 ratio (p = 0.0001). Higher PCB levels were associated with higher free T4 (p = 0.0002), and higher free T3: free T4 ratio (p = 0.002). Importantly, the association between PBB and thyroid hormones was dependent on age at exposure. Among people exposed before age 16 (N = 446), higher PBB exposure was associated with higher total T3 (p = 0.01) and free T3 (p = 0.0003), lower free T4 (p = 0.04), and higher free T3: free T4 ratio (p = 0.0001). No significant associations were found among participants who were exposed after age 16. No significant associations were found between TSH and PBB or PCB in any of the analyses conducted. CONCLUSIONS: This suggests that both PBB and PCB are associated with thyroid function, particularly among those who were exposed as children or prenatally. SN - 1476-069X UR - https://www.unboundmedicine.com/medline/citation/31443693/Thyroid_hormone_levels_associate_with_exposure_to_polychlorinated_biphenyls_and_polybrominated_biphenyls_in_adults_exposed_as_children L2 - https://ehjournal.biomedcentral.com/articles/10.1186/s12940-019-0509-z DB - PRIME DP - Unbound Medicine ER -