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Autoantibodies in immune-mediated inflammatory neuropathies.

Abstract

Inflammatory neuropathies are a rare and heterogeneous group of diseases of the nervous system characterized by the dysfunction and damage of different structures of the peripheral nerves. This group includes Guillain-Barré syndrome, chronic demyelinating inflammatory polyradiculoneuropathy, multifocal motor neuropathy or neuropathies associated with monoclonal gammopathy. The aetiology of these diseases is unknown, but B cells and autoantibodies play a key role in their pathogenesis. Autoantibodies against peripheral nerve molecules such as gangliosides, proteins of the Ranvier node or myelin-associated glycoprotein have been described, allowing the identification of subgroups of patients with specific clinical phenotypes. For all these reasons, these antibodies are useful in clinical practice. This review focuses on the diagnostic and therapeutic relevance of autoantibodies in inflammatory neuropathies.

Authors+Show Affiliations

Unidad de Enfermedades Neuromusculares, Hospital de la Santa Creu i Sant Pau, Barcelona, España.Unidad de Enfermedades Neuromusculares, Hospital de la Santa Creu i Sant Pau, Barcelona, España.Unidad de Enfermedades Neuromusculares, Hospital de la Santa Creu i Sant Pau, Barcelona, España. Electronic address: lquerol@santpau.cat.

Pub Type(s)

Journal Article
Review

Language

eng spa

PubMed ID

31443948

Citation

Martín-Aguilar, Lorena, et al. "Autoantibodies in Immune-mediated Inflammatory Neuropathies." Medicina Clinica, 2019.
Martín-Aguilar L, Pascual-Goñi E, Querol L. Autoantibodies in immune-mediated inflammatory neuropathies. Med Clin (Barc). 2019.
Martín-Aguilar, L., Pascual-Goñi, E., & Querol, L. (2019). Autoantibodies in immune-mediated inflammatory neuropathies. Medicina Clinica, doi:10.1016/j.medcli.2019.06.007.
Martín-Aguilar L, Pascual-Goñi E, Querol L. Autoantibodies in Immune-mediated Inflammatory Neuropathies. Med Clin (Barc). 2019 Aug 20; PubMed PMID: 31443948.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Autoantibodies in immune-mediated inflammatory neuropathies. AU - Martín-Aguilar,Lorena, AU - Pascual-Goñi,Elba, AU - Querol,Luis, Y1 - 2019/08/20/ PY - 2019/03/14/received PY - 2019/05/30/revised PY - 2019/06/04/accepted PY - 2019/8/25/entrez KW - Autoantibodies KW - Autoanticuerpos KW - CIDP KW - GMSI-P KW - Guillain-Barré syndrome KW - Immune-mediated neuropathies KW - MGUS-P KW - Multifocal motor neuropathy KW - Neuropatía motora multifocal KW - Neuropatías inmunomediadas KW - Síndrome de Guillain-Barré JF - Medicina clinica JO - Med Clin (Barc) N2 - Inflammatory neuropathies are a rare and heterogeneous group of diseases of the nervous system characterized by the dysfunction and damage of different structures of the peripheral nerves. This group includes Guillain-Barré syndrome, chronic demyelinating inflammatory polyradiculoneuropathy, multifocal motor neuropathy or neuropathies associated with monoclonal gammopathy. The aetiology of these diseases is unknown, but B cells and autoantibodies play a key role in their pathogenesis. Autoantibodies against peripheral nerve molecules such as gangliosides, proteins of the Ranvier node or myelin-associated glycoprotein have been described, allowing the identification of subgroups of patients with specific clinical phenotypes. For all these reasons, these antibodies are useful in clinical practice. This review focuses on the diagnostic and therapeutic relevance of autoantibodies in inflammatory neuropathies. SN - 1578-8989 UR - https://www.unboundmedicine.com/medline/citation/31443948/Autoantibodies_in_immune-mediated_inflammatory_neuropathies L2 - http://www.elsevier.es/en/linksolver/ft/pii/S0025-7753(19)30448-8 DB - PRIME DP - Unbound Medicine ER -