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Is heart rate variability a valuable method to investigate cardiac autonomic dysfunction in subjects with leukemia? A systematic review to evaluate its importance in clinical practice.

Abstract

Impaired cardiovascular and autonomic function during treatment and during recovery from leukemia has been indicated. In this context, heart rate variability (HRV) is a non-invasive measure that describes the oscillations of the intervals between consecutive heart beats (RR intervals), influenced by the autonomic nervous system. We intend to review literature showing HRV changes in leukemia subjects. The articles selected in the current review were attained up to March 2018, and the search was limited to articles in English language, published in peer-reviewed journals, with both adult and child age samples. The articles were investigated in the five electronic databases: PubMed, Physiotherapy Evidence Database (PEDro), Cochrane Clinical Trials, Scientific Electronic Library Online (SciELO), and Excerpta Medica dataBASE (EMBASE). Towards the end of the research, 9 studies were included. Subjects undergoing treatment for leukemia have reduced HRV, signifying decreased vagal control of heart rate. The subjects that undertook leukemia treatment and their survivors experienced a reduction in HRV with subsequent recovery, but the recovery time is ill defined. HRV is reduced in leukemia subjects who progress to neuropathy secondary to chemotherapy, accompanied by cardiac dysfunction. We advocate the use of HRV to evaluate autonomic function and decide the treatment to prevent autonomic impairment in leukemia subjects.

Authors+Show Affiliations

Autonomic Nervous System Center, Sao Paulo State University, UNESP, Presidente Prudente, SP, Brazil.Cardiorespiratory Research Group, Department of Biological and Medical Sciences, Faculty of Health and Life Sciences, Oxford Brookes University, Headington Campus, Gipsy Lane, Oxford, OX3 0BP, UK.Department of Medicine (Cardiology), Federal University of São Paulo (UNIFESP), Sao Paulo, SP, Brazil.Autonomic Nervous System Center, Sao Paulo State University, UNESP, Presidente Prudente, SP, Brazil. vitor.valenti@unesp.br. UNESP, Av. Hygino Muzzi Filho, 737, Mirante, Marília, SP, 17.525-900, Brazil. vitor.valenti@unesp.br.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31444641

Citation

Kirizawa, Jociele M., et al. "Is Heart Rate Variability a Valuable Method to Investigate Cardiac Autonomic Dysfunction in Subjects With Leukemia? a Systematic Review to Evaluate Its Importance in Clinical Practice." Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer, 2019.
Kirizawa JM, Garner DM, Arab C, et al. Is heart rate variability a valuable method to investigate cardiac autonomic dysfunction in subjects with leukemia? A systematic review to evaluate its importance in clinical practice. Support Care Cancer. 2019.
Kirizawa, J. M., Garner, D. M., Arab, C., & Valenti, V. E. (2019). Is heart rate variability a valuable method to investigate cardiac autonomic dysfunction in subjects with leukemia? A systematic review to evaluate its importance in clinical practice. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer, doi:10.1007/s00520-019-05047-x.
Kirizawa JM, et al. Is Heart Rate Variability a Valuable Method to Investigate Cardiac Autonomic Dysfunction in Subjects With Leukemia? a Systematic Review to Evaluate Its Importance in Clinical Practice. Support Care Cancer. 2019 Aug 23; PubMed PMID: 31444641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is heart rate variability a valuable method to investigate cardiac autonomic dysfunction in subjects with leukemia? A systematic review to evaluate its importance in clinical practice. AU - Kirizawa,Jociele M, AU - Garner,David M, AU - Arab,Claudia, AU - Valenti,Vitor E, Y1 - 2019/08/23/ PY - 2019/05/30/received PY - 2019/08/16/accepted PY - 2019/8/25/entrez KW - Autonomic nervous system KW - Cardiovascular physiology KW - Heart rate KW - Leukemia, myeloid acute, lymphoid acute JF - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer JO - Support Care Cancer N2 - Impaired cardiovascular and autonomic function during treatment and during recovery from leukemia has been indicated. In this context, heart rate variability (HRV) is a non-invasive measure that describes the oscillations of the intervals between consecutive heart beats (RR intervals), influenced by the autonomic nervous system. We intend to review literature showing HRV changes in leukemia subjects. The articles selected in the current review were attained up to March 2018, and the search was limited to articles in English language, published in peer-reviewed journals, with both adult and child age samples. The articles were investigated in the five electronic databases: PubMed, Physiotherapy Evidence Database (PEDro), Cochrane Clinical Trials, Scientific Electronic Library Online (SciELO), and Excerpta Medica dataBASE (EMBASE). Towards the end of the research, 9 studies were included. Subjects undergoing treatment for leukemia have reduced HRV, signifying decreased vagal control of heart rate. The subjects that undertook leukemia treatment and their survivors experienced a reduction in HRV with subsequent recovery, but the recovery time is ill defined. HRV is reduced in leukemia subjects who progress to neuropathy secondary to chemotherapy, accompanied by cardiac dysfunction. We advocate the use of HRV to evaluate autonomic function and decide the treatment to prevent autonomic impairment in leukemia subjects. SN - 1433-7339 UR - https://www.unboundmedicine.com/medline/citation/31444641/Is_heart_rate_variability_a_valuable_method_to_investigate_cardiac_autonomic_dysfunction_in_subjects_with_leukemia_A_systematic_review_to_evaluate_its_importance_in_clinical_practice L2 - https://dx.doi.org/10.1007/s00520-019-05047-x DB - PRIME DP - Unbound Medicine ER -