Tags

Type your tag names separated by a space and hit enter

Differences in clinicopathologic variables between Borrelia C6 antigen seroreactive and Borrelia C6 seronegative glomerulopathy in dogs.
J Vet Intern Med 2019; 33(5):2096-2104JV

Abstract

BACKGROUND

Rapidly progressive glomerulonephritis has been described in dogs that seroreact to Borrelia burgdorferi, but no studies have compared clinicopathologic differences in Lyme-seroreactive dogs with protein-losing nephropathy (PLN) versus dogs with Borrelia-seronegative PLN.

HYPOTHESIS/OBJECTIVES

Dogs with Borrelia C6 antigen-seroreactive PLN have distinct clinicopathologic findings when compared to dogs with Borrelia seronegative PLN.

ANIMALS

Forty dogs with PLN and Borrelia C6 antigen seroreactivity and 78 C6-seronegative temporally matched dogs with PLN.

METHODS

Retrospective prevalence case-control study. Clinical information was retrieved from records of dogs examined at the University of California, Davis, Veterinary Medical Teaching Hospital. Histopathologic findings in renal tissue procured by biopsy or necropsy of dogs with PLN were reviewed.

RESULTS

Retrievers and retriever mixes were overrepresented in seroreactive dogs (P < .001). Seroreactive dogs were more likely to have thrombocytopenia (P < .001), azotemia (P = .002), hyperphosphatemia (P < .001), anemia (P < .001), and neutrophilia (P = .003). Hematuria, glucosuria, and pyuria despite negative urine culture were more likely in seroreactive dogs (all P ≤ .002). Histopathologic findings were consistent with immune-complex glomerulonephritis in 16 of 16 case dogs and 7 of 23 control dogs (P = 006). Prevalence of polyarthritis was not different between groups (P = .17).

CONCLUSIONS AND CLINICAL IMPORTANCE

C6 seroreactivity in dogs with PLN is associated with a clinicopathologically distinct syndrome when compared with other types of PLN. Early recognition of this syndrome has the potential to improve outcomes through specific aggressive and early treatment.

Authors+Show Affiliations

Veterinary Medical Teaching Hospital, University of California-Davis, Davis, California.Department of Population Health and Reproduction, University of California-Davis, Davis, California.Department of Pathology, Microbiology, and Immunology, University of California-Davis, Davis, California.Department of Medicine and Epidemiology, University of California-Davis, Davis, California.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31444996

Citation

Borys, Moria A., et al. "Differences in Clinicopathologic Variables Between Borrelia C6 Antigen Seroreactive and Borrelia C6 Seronegative Glomerulopathy in Dogs." Journal of Veterinary Internal Medicine, vol. 33, no. 5, 2019, pp. 2096-2104.
Borys MA, Kass PH, Mohr FC, et al. Differences in clinicopathologic variables between Borrelia C6 antigen seroreactive and Borrelia C6 seronegative glomerulopathy in dogs. J Vet Intern Med. 2019;33(5):2096-2104.
Borys, M. A., Kass, P. H., Mohr, F. C., & Sykes, J. E. (2019). Differences in clinicopathologic variables between Borrelia C6 antigen seroreactive and Borrelia C6 seronegative glomerulopathy in dogs. Journal of Veterinary Internal Medicine, 33(5), pp. 2096-2104. doi:10.1111/jvim.15586.
Borys MA, et al. Differences in Clinicopathologic Variables Between Borrelia C6 Antigen Seroreactive and Borrelia C6 Seronegative Glomerulopathy in Dogs. J Vet Intern Med. 2019;33(5):2096-2104. PubMed PMID: 31444996.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences in clinicopathologic variables between Borrelia C6 antigen seroreactive and Borrelia C6 seronegative glomerulopathy in dogs. AU - Borys,Moria A, AU - Kass,Philip H, AU - Mohr,Frederick C, AU - Sykes,Jane E, Y1 - 2019/08/24/ PY - 2018/08/02/received PY - 2019/07/23/accepted PY - 2019/8/25/pubmed PY - 2019/8/25/medline PY - 2019/8/25/entrez KW - Lyme disease KW - PLN KW - glomerulonephritis KW - polyarthritis KW - pyuria KW - thrombocytopenia SP - 2096 EP - 2104 JF - Journal of veterinary internal medicine JO - J. Vet. Intern. Med. VL - 33 IS - 5 N2 - BACKGROUND: Rapidly progressive glomerulonephritis has been described in dogs that seroreact to Borrelia burgdorferi, but no studies have compared clinicopathologic differences in Lyme-seroreactive dogs with protein-losing nephropathy (PLN) versus dogs with Borrelia-seronegative PLN. HYPOTHESIS/OBJECTIVES: Dogs with Borrelia C6 antigen-seroreactive PLN have distinct clinicopathologic findings when compared to dogs with Borrelia seronegative PLN. ANIMALS: Forty dogs with PLN and Borrelia C6 antigen seroreactivity and 78 C6-seronegative temporally matched dogs with PLN. METHODS: Retrospective prevalence case-control study. Clinical information was retrieved from records of dogs examined at the University of California, Davis, Veterinary Medical Teaching Hospital. Histopathologic findings in renal tissue procured by biopsy or necropsy of dogs with PLN were reviewed. RESULTS: Retrievers and retriever mixes were overrepresented in seroreactive dogs (P < .001). Seroreactive dogs were more likely to have thrombocytopenia (P < .001), azotemia (P = .002), hyperphosphatemia (P < .001), anemia (P < .001), and neutrophilia (P = .003). Hematuria, glucosuria, and pyuria despite negative urine culture were more likely in seroreactive dogs (all P ≤ .002). Histopathologic findings were consistent with immune-complex glomerulonephritis in 16 of 16 case dogs and 7 of 23 control dogs (P = 006). Prevalence of polyarthritis was not different between groups (P = .17). CONCLUSIONS AND CLINICAL IMPORTANCE: C6 seroreactivity in dogs with PLN is associated with a clinicopathologically distinct syndrome when compared with other types of PLN. Early recognition of this syndrome has the potential to improve outcomes through specific aggressive and early treatment. SN - 1939-1676 UR - https://www.unboundmedicine.com/medline/citation/31444996/Differences_in_clinicopathologic_variables_between_Borrelia_C6_antigen_seroreactive_and_Borrelia_C6_seronegative_glomerulopathy_in_dogs L2 - https://doi.org/10.1111/jvim.15586 DB - PRIME DP - Unbound Medicine ER -