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Photodynamic therapy enhancing anti-skin cancer chemotherapy effects through autophagy regulation.

Abstract

Non-melanotic cutaneous cancers and melanoma are the main common type skin cancers worldwide, and squamous cell carcinoma (SCC) and melanoma were most serious and high aggressive. Despite many therapeutic options, but the therapeutic efficacy is not satisfied in all patients with advanced skin cancers, especially in melanoma. Photodynamic therapy (PDT) is a technology for skin disease treatment because of its high effectiveness, no drug resistance or toxic side effect and easy to use compared with traditional therapy. Our previous study explored that autophagy plays an important role in the formation and development of SCC. But there was no evidence about the association between PDT with autophagy in skin cancers and the mechanism is also still unclear. In the study, we want to explore the effects of 5-aminolevulinic acid-PDT (ALA-PDT) on the skin cancers through autophagy regulation. The result showed that autophagy was regulated by ALA-PDT combined with or without 3-Methyladenine (3-MA) or 5-Fluoracil (5-FU), the proliferation of skin cancer cells A431 and A375 were suppressed while the apoptosis were induced by ALA-PDT and the effects can be enhanced by 3-MA or 5-FU pretreated. The results suggest that autophagy regulation may be a key point of ALA-PDT therapy; ALA-PDT combined with the chemotherapy of 3-FU or 5-FU may be a new strategy for treatment of skin cancers including non-melanotic cutaneous cancers or melanoma.

Authors+Show Affiliations

Department of Dermatology, Hospital of Nantong University, Nantong, 226001, PR China.Department of Dermatology, Hospital of Nantong University, Nantong, 226001, PR China.Department of Dermatology, Hospital of Nantong University, Nantong, 226001, PR China. Electronic address: zhangjie7401@163.com.Department of Dermatology, Hospital of Nantong University, Nantong, 226001, PR China. Electronic address: yangshengju80@163.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31445100

Citation

Zhang, Lili, et al. "Photodynamic Therapy Enhancing Anti-skin Cancer Chemotherapy Effects Through Autophagy Regulation." Photodiagnosis and Photodynamic Therapy, 2019.
Zhang L, Ji Z, Zhang J, et al. Photodynamic therapy enhancing anti-skin cancer chemotherapy effects through autophagy regulation. Photodiagnosis Photodyn Ther. 2019.
Zhang, L., Ji, Z., Zhang, J., & Yang, S. (2019). Photodynamic therapy enhancing anti-skin cancer chemotherapy effects through autophagy regulation. Photodiagnosis and Photodynamic Therapy, doi:10.1016/j.pdpdt.2019.08.023.
Zhang L, et al. Photodynamic Therapy Enhancing Anti-skin Cancer Chemotherapy Effects Through Autophagy Regulation. Photodiagnosis Photodyn Ther. 2019 Aug 21; PubMed PMID: 31445100.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Photodynamic therapy enhancing anti-skin cancer chemotherapy effects through autophagy regulation. AU - Zhang,Lili, AU - Ji,Zhoujing, AU - Zhang,Jie, AU - Yang,Shengju, Y1 - 2019/08/21/ PY - 2019/04/08/received PY - 2019/08/19/revised PY - 2019/08/20/accepted PY - 2019/8/25/entrez PY - 2019/8/25/pubmed PY - 2019/8/25/medline KW - apoptosis KW - autophagy KW - chemotherapy KW - photodynamic therapy KW - skin cancer JF - Photodiagnosis and photodynamic therapy JO - Photodiagnosis Photodyn Ther N2 - Non-melanotic cutaneous cancers and melanoma are the main common type skin cancers worldwide, and squamous cell carcinoma (SCC) and melanoma were most serious and high aggressive. Despite many therapeutic options, but the therapeutic efficacy is not satisfied in all patients with advanced skin cancers, especially in melanoma. Photodynamic therapy (PDT) is a technology for skin disease treatment because of its high effectiveness, no drug resistance or toxic side effect and easy to use compared with traditional therapy. Our previous study explored that autophagy plays an important role in the formation and development of SCC. But there was no evidence about the association between PDT with autophagy in skin cancers and the mechanism is also still unclear. In the study, we want to explore the effects of 5-aminolevulinic acid-PDT (ALA-PDT) on the skin cancers through autophagy regulation. The result showed that autophagy was regulated by ALA-PDT combined with or without 3-Methyladenine (3-MA) or 5-Fluoracil (5-FU), the proliferation of skin cancer cells A431 and A375 were suppressed while the apoptosis were induced by ALA-PDT and the effects can be enhanced by 3-MA or 5-FU pretreated. The results suggest that autophagy regulation may be a key point of ALA-PDT therapy; ALA-PDT combined with the chemotherapy of 3-FU or 5-FU may be a new strategy for treatment of skin cancers including non-melanotic cutaneous cancers or melanoma. SN - 1873-1597 UR - https://www.unboundmedicine.com/medline/citation/31445100/Photodynamic_therapy_enhancing_anti-skin_cancer_chemotherapy_effects_through_autophagy_regulation L2 - https://linkinghub.elsevier.com/retrieve/pii/S1572-1000(19)30168-1 DB - PRIME DP - Unbound Medicine ER -