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Clinicians' Guide to Cannabidiol and Hemp Oils.
Mayo Clin Proc. 2019 09; 94(9):1840-1851.MC

Abstract

Cannabidiol (CBD) oils are low tetrahydrocannabinol products derived from Cannabis sativa that have become very popular over the past few years. Patients report relief for a variety of conditions, particularly pain, without the intoxicating adverse effects of medical marijuana. In June 2018, the first CBD-based drug, Epidiolex, was approved by the US Food and Drug Administration for treatment of rare, severe epilepsy, further putting the spotlight on CBD and hemp oils. There is a growing body of preclinical and clinical evidence to support use of CBD oils for many conditions, suggesting its potential role as another option for treating challenging chronic pain or opioid addiction. Care must be taken when directing patients toward CBD products because there is little regulation, and studies have found inaccurate labeling of CBD and tetrahydrocannabinol quantities. This article provides an overview of the scientific work on cannabinoids, CBD, and hemp oil and the distinction between marijuana, hemp, and the different components of CBD and hemp oil products. We summarize the current legal status of CBD and hemp oils in the United States and provide a guide to identifying higher-quality products so that clinicians can advise their patients on the safest and most evidence-based formulations. This review is based on a PubMed search using the terms CBD, cannabidiol, hemp oil, and medical marijuana. Articles were screened for relevance, and those with the most up-to-date information were selected for inclusion.

Authors+Show Affiliations

Creighton University School of Medicine, Omaha, NE. Electronic address: hjv72661@creighton.edu.Section of Integrative Medicine and Health, Mayo Clinic, Rochester, MN.Division of General Internal Medicine, Mayo Clinic, Rochester, MN.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31447137

Citation

VanDolah, Harrison J., et al. "Clinicians' Guide to Cannabidiol and Hemp Oils." Mayo Clinic Proceedings, vol. 94, no. 9, 2019, pp. 1840-1851.
VanDolah HJ, Bauer BA, Mauck KF. Clinicians' Guide to Cannabidiol and Hemp Oils. Mayo Clin Proc. 2019;94(9):1840-1851.
VanDolah, H. J., Bauer, B. A., & Mauck, K. F. (2019). Clinicians' Guide to Cannabidiol and Hemp Oils. Mayo Clinic Proceedings, 94(9), 1840-1851. https://doi.org/10.1016/j.mayocp.2019.01.003
VanDolah HJ, Bauer BA, Mauck KF. Clinicians' Guide to Cannabidiol and Hemp Oils. Mayo Clin Proc. 2019;94(9):1840-1851. PubMed PMID: 31447137.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinicians' Guide to Cannabidiol and Hemp Oils. AU - VanDolah,Harrison J, AU - Bauer,Brent A, AU - Mauck,Karen F, Y1 - 2019/08/22/ PY - 2018/08/03/received PY - 2018/12/03/revised PY - 2019/01/04/accepted PY - 2019/8/27/pubmed PY - 2020/1/14/medline PY - 2019/8/27/entrez SP - 1840 EP - 1851 JF - Mayo Clinic proceedings JO - Mayo Clin Proc VL - 94 IS - 9 N2 - Cannabidiol (CBD) oils are low tetrahydrocannabinol products derived from Cannabis sativa that have become very popular over the past few years. Patients report relief for a variety of conditions, particularly pain, without the intoxicating adverse effects of medical marijuana. In June 2018, the first CBD-based drug, Epidiolex, was approved by the US Food and Drug Administration for treatment of rare, severe epilepsy, further putting the spotlight on CBD and hemp oils. There is a growing body of preclinical and clinical evidence to support use of CBD oils for many conditions, suggesting its potential role as another option for treating challenging chronic pain or opioid addiction. Care must be taken when directing patients toward CBD products because there is little regulation, and studies have found inaccurate labeling of CBD and tetrahydrocannabinol quantities. This article provides an overview of the scientific work on cannabinoids, CBD, and hemp oil and the distinction between marijuana, hemp, and the different components of CBD and hemp oil products. We summarize the current legal status of CBD and hemp oils in the United States and provide a guide to identifying higher-quality products so that clinicians can advise their patients on the safest and most evidence-based formulations. This review is based on a PubMed search using the terms CBD, cannabidiol, hemp oil, and medical marijuana. Articles were screened for relevance, and those with the most up-to-date information were selected for inclusion. SN - 1942-5546 UR - https://www.unboundmedicine.com/medline/citation/31447137/Clinicians'_Guide_to_Cannabidiol_and_Hemp_Oils_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0025-6196(19)30007-2 DB - PRIME DP - Unbound Medicine ER -