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Myoclonus inducing and seizure modifying effect of cysteamine on cortical and amygdaloid kindled rats.
Brain Res. 1988 Nov 08; 473(1):99-106.BR

Abstract

The effect of the somatostatin depleting substance, cysteamine (100 mg/kg, i.p.), on cortical and amygdaloid kindled seizures was investigated. Cysteamine was tested after the establishment of amygdaloid kindling (AM group) and at two different developmental stages of cortical kindling, namely 'focal-cortical' (FC group) and 'cortico-generalized' seizures (CG group). In control, non-kindled, sham operated animals, cysteamine did not induce any spike activity or myoclonus. However, in all kindled groups clustered spike bursting appeared in the cortex within 5-15 min of the injection. The kindled bursting appeared in the cortex within 5-15 min of the injection. The kindled rats exhibited myoclonic jerks at 10 to 30 min after cysteamine injection, which coincided with the cortical spikes, and continued for about 40 min. In contrast, relatively small amounts of spiking were observed in the amygdala and this did not correlate with the myoclonus. At 4 h after cysteamine injection, the motor seizure and afterdischarge durations of the kindled seizure were prolonged in all kindled groups compared with preinjection levels. However, 24 h later the motor seizure duration and the afterdischarge duration were markedly reduced from the preinjection level in the AM and the CG groups and the tonic seizure component was suppressed in the FC group. This inhibitory effect on seizure activity lasted several days and gradually disappeared. These modifying effects of cysteamine were more marked in cortical kindled, than in amygdaloid kindled animals. The results suggest that the cortex is more sensitive to the effect of cysteamine on kindled seizures involves two phases. The first of these effect of cysteamine on kindled seizures involves two phases.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Takazawa A
Department of Psychology, University of Otago, Dunedin, New Zealand.
Bilkey DK
No affiliation info available

MeSH

AmygdalaAnimalsCerebral CortexCysteamineElectroencephalographyEpilepsies, MyoclonicKindling, NeurologicMaleRatsRats, Inbred StrainsTime Factors

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3145096

Citation

Takazawa, A, and D K. Bilkey. "Myoclonus Inducing and Seizure Modifying Effect of Cysteamine On Cortical and Amygdaloid Kindled Rats." Brain Research, vol. 473, no. 1, 1988, pp. 99-106.
Takazawa A, Bilkey DK. Myoclonus inducing and seizure modifying effect of cysteamine on cortical and amygdaloid kindled rats. Brain Res. 1988;473(1):99-106.
Takazawa, A., & Bilkey, D. K. (1988). Myoclonus inducing and seizure modifying effect of cysteamine on cortical and amygdaloid kindled rats. Brain Research, 473(1), 99-106.
Takazawa A, Bilkey DK. Myoclonus Inducing and Seizure Modifying Effect of Cysteamine On Cortical and Amygdaloid Kindled Rats. Brain Res. 1988 Nov 8;473(1):99-106. PubMed PMID: 3145096.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Myoclonus inducing and seizure modifying effect of cysteamine on cortical and amygdaloid kindled rats. AU - Takazawa,A, AU - Bilkey,D K, PY - 1988/11/8/pubmed PY - 1988/11/8/medline PY - 1988/11/8/entrez SP - 99 EP - 106 JF - Brain research JO - Brain Res VL - 473 IS - 1 N2 - The effect of the somatostatin depleting substance, cysteamine (100 mg/kg, i.p.), on cortical and amygdaloid kindled seizures was investigated. Cysteamine was tested after the establishment of amygdaloid kindling (AM group) and at two different developmental stages of cortical kindling, namely 'focal-cortical' (FC group) and 'cortico-generalized' seizures (CG group). In control, non-kindled, sham operated animals, cysteamine did not induce any spike activity or myoclonus. However, in all kindled groups clustered spike bursting appeared in the cortex within 5-15 min of the injection. The kindled bursting appeared in the cortex within 5-15 min of the injection. The kindled rats exhibited myoclonic jerks at 10 to 30 min after cysteamine injection, which coincided with the cortical spikes, and continued for about 40 min. In contrast, relatively small amounts of spiking were observed in the amygdala and this did not correlate with the myoclonus. At 4 h after cysteamine injection, the motor seizure and afterdischarge durations of the kindled seizure were prolonged in all kindled groups compared with preinjection levels. However, 24 h later the motor seizure duration and the afterdischarge duration were markedly reduced from the preinjection level in the AM and the CG groups and the tonic seizure component was suppressed in the FC group. This inhibitory effect on seizure activity lasted several days and gradually disappeared. These modifying effects of cysteamine were more marked in cortical kindled, than in amygdaloid kindled animals. The results suggest that the cortex is more sensitive to the effect of cysteamine on kindled seizures involves two phases. The first of these effect of cysteamine on kindled seizures involves two phases.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0006-8993 UR - https://www.unboundmedicine.com/medline/citation/3145096/Myoclonus_inducing_and_seizure_modifying_effect_of_cysteamine_on_cortical_and_amygdaloid_kindled_rats_ DB - PRIME DP - Unbound Medicine ER -