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[Use of Ommaya Reservoirs to Deliver Pemetrexed in Leptomeningeal Metastasis from Non-small Cell Lung Cancer: A Case Report and Review of the Literature].
Zhongguo Fei Ai Za Zhi. 2019 Aug 20; 22(8):546-550.ZF

Abstract

Leptomeningeal metastasis (LM) is one of the most severe complications of non-small-cell lung cancer (NSCLC), and its incidence is increasing gradually with the progress of targeted therapies. There are currently no standard guidelines for the therapy of LM. Intrathecal chemotherapy is the mainstay of treatment for NSCLC patients with LM, but the optimal drug, administration route and mode, and dosage remain unclear. We report a case of LM from NSCLC, who received the intrathecal chemotherapy with pemetrexed by Ommaya reservoir after prior targeted therapies. This local treatment improved the quality of life, and obtained the clearing of CSF cytology and stable lesions of LM without any notable side effects. After confirmation of LM, the patient has survived 17 months until now. Here we report the first case to demonstrate the potential effectiveness of intrathecal pemetrexed by Ommaya reservoir for the treatment of LM of NSCLC, summarize the safety and effectiveness of intrathecal chemotherapy in combination with related literatures, and provide a new strategy for local treatment of LM in clinical. .

Authors+Show Affiliations

Department of Geriatric Oncology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.Department of Geriatric Oncology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.Department of Geriatric Oncology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.Department of Geriatric Oncology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.Department of Geriatric Oncology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.

Pub Type(s)

Case Reports
Journal Article
Review

Language

chi

PubMed ID

31451148

Citation

Lin, Yongjuan, et al. "[Use of Ommaya Reservoirs to Deliver Pemetrexed in Leptomeningeal Metastasis From Non-small Cell Lung Cancer: a Case Report and Review of the Literature]." Zhongguo Fei Ai Za Zhi = Chinese Journal of Lung Cancer, vol. 22, no. 8, 2019, pp. 546-550.
Lin Y, Li H, Huang M, et al. [Use of Ommaya Reservoirs to Deliver Pemetrexed in Leptomeningeal Metastasis from Non-small Cell Lung Cancer: A Case Report and Review of the Literature]. Zhongguo Fei Ai Za Zhi. 2019;22(8):546-550.
Lin, Y., Li, H., Huang, M., Guo, A., & Yin, Z. (2019). [Use of Ommaya Reservoirs to Deliver Pemetrexed in Leptomeningeal Metastasis from Non-small Cell Lung Cancer: A Case Report and Review of the Literature]. Zhongguo Fei Ai Za Zhi = Chinese Journal of Lung Cancer, 22(8), 546-550. https://doi.org/10.3779/j.issn.1009-3419.2019.08.12
Lin Y, et al. [Use of Ommaya Reservoirs to Deliver Pemetrexed in Leptomeningeal Metastasis From Non-small Cell Lung Cancer: a Case Report and Review of the Literature]. Zhongguo Fei Ai Za Zhi. 2019 Aug 20;22(8):546-550. PubMed PMID: 31451148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Use of Ommaya Reservoirs to Deliver Pemetrexed in Leptomeningeal Metastasis from Non-small Cell Lung Cancer: A Case Report and Review of the Literature]. AU - Lin,Yongjuan, AU - Li,Huiying, AU - Huang,Mingmin, AU - Guo,Aibin, AU - Yin,Zhenyu, PY - 2019/8/28/entrez PY - 2019/8/28/pubmed PY - 2020/1/4/medline KW - Leptomeningeal metastasis KW - Lung neoplasms KW - Ommaya reservoir KW - Pemetrexed SP - 546 EP - 550 JF - Zhongguo fei ai za zhi = Chinese journal of lung cancer JO - Zhongguo Fei Ai Za Zhi VL - 22 IS - 8 N2 - Leptomeningeal metastasis (LM) is one of the most severe complications of non-small-cell lung cancer (NSCLC), and its incidence is increasing gradually with the progress of targeted therapies. There are currently no standard guidelines for the therapy of LM. Intrathecal chemotherapy is the mainstay of treatment for NSCLC patients with LM, but the optimal drug, administration route and mode, and dosage remain unclear. We report a case of LM from NSCLC, who received the intrathecal chemotherapy with pemetrexed by Ommaya reservoir after prior targeted therapies. This local treatment improved the quality of life, and obtained the clearing of CSF cytology and stable lesions of LM without any notable side effects. After confirmation of LM, the patient has survived 17 months until now. Here we report the first case to demonstrate the potential effectiveness of intrathecal pemetrexed by Ommaya reservoir for the treatment of LM of NSCLC, summarize the safety and effectiveness of intrathecal chemotherapy in combination with related literatures, and provide a new strategy for local treatment of LM in clinical. . SN - 1999-6187 UR - https://www.unboundmedicine.com/medline/citation/31451148/[Use_of_Ommaya_Reservoirs_to_Deliver_Pemetrexed_in_Leptomeningeal_Metastasis_from_Non_small_Cell_Lung_Cancer:_A_Case_Report_and_Review_of_the_Literature]_ L2 - https://doi.org/10.3779/j.issn.1009-3419.2019.08.12 DB - PRIME DP - Unbound Medicine ER -