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Total protein or leucine intakes are not associated with handgrip strength in hemodialysis patients: A pilot study.
Clin Nutr ESPEN 2019; 33:290-293CN

Abstract

BACKGROUND & AIMS

Inadequate protein intake is associated with lean body mass (LBM) loss. However, it is unclear whether high protein diet and leucine intake are associated with handgrip strength (HGS), a validated marker of muscle function. This study aims to: i) assess the prevalence of patients with low HGS; and ii) verify if HGS is correlated with high protein diet and leucine consumption in hemodialysis patients.

METHODS

This cross-sectional study analysed patients at two center hemodialysis (HD) clinic and sixty-two patients aged ∼39 years with length of time on HD ∼60 months undergoing HD was carried out. Body weight (kg), LBM (kg) and body fat mass (%) assessments were performed by dual-energy X-ray absorptiometry and height (m) through portable stadiometer. Body mass index (BMI) (kg/m2) was calculated using the body weight and height. HGS (kg) was measured using a hydraulic dynamometer. Fisher's exact test, Chi-square, Pearson's correlation, and logistic regression were done to test the hypothesis.

RESULTS

Out of 62 patients, 47 (75.8%) presented low HGS. In addition, no correlation was found between protein intake (if in percentage or g/kg/d) and HGS (r = 0.07, p = 0.58; r = -0.04, p = 0.70, respectively). Although there is a low correlation among leucine intake (g/d) and HGS (r = 0.39, p = 0.01), low HGS was not associated with leucine intake in the crude model (OR: 0.86 95%CI(0.60-1.24) p = 0.441), nor after adjustment for age, sex and BMI (OR: 0.84 95%CI(0.56-1.26), p = 0.422).

CONCLUSIONS

Approximately 75% of patients undergoing hemodialysis presented low HGS. Additionally, neither a high protein diet nor leucine intake was associated with the HGS values.

Authors+Show Affiliations

Clinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goias, Goiânia, GO, Brazil.Clinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goias, Goiânia, GO, Brazil.Clinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goias, Goiânia, GO, Brazil.Department of Clinical Medicine, Sapienza University, Viale dell'Università 37, 00185 Rome, Italy.Clinical Nutrition, Geneva University Hospital, Geneva, Switzerland.Clinical and Sports Nutrition Research Laboratory (Labince), Faculty of Nutrition, Federal University of Goias, Goiânia, GO, Brazil. Electronic address: gupimentel@yahoo.com.br.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31451270

Citation

Marini, Ana C B., et al. "Total Protein or Leucine Intakes Are Not Associated With Handgrip Strength in Hemodialysis Patients: a Pilot Study." Clinical Nutrition ESPEN, vol. 33, 2019, pp. 290-293.
Marini ACB, Motobu RD, Freitas ATV, et al. Total protein or leucine intakes are not associated with handgrip strength in hemodialysis patients: A pilot study. Clin Nutr ESPEN. 2019;33:290-293.
Marini, A. C. B., Motobu, R. D., Freitas, A. T. V., Laviano, A., Pichard, C., & Pimentel, G. D. (2019). Total protein or leucine intakes are not associated with handgrip strength in hemodialysis patients: A pilot study. Clinical Nutrition ESPEN, 33, pp. 290-293. doi:10.1016/j.clnesp.2019.05.017.
Marini ACB, et al. Total Protein or Leucine Intakes Are Not Associated With Handgrip Strength in Hemodialysis Patients: a Pilot Study. Clin Nutr ESPEN. 2019;33:290-293. PubMed PMID: 31451270.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Total protein or leucine intakes are not associated with handgrip strength in hemodialysis patients: A pilot study. AU - Marini,Ana C B, AU - Motobu,Reika D, AU - Freitas,Ana T V, AU - Laviano,Alessandro, AU - Pichard,Claude, AU - Pimentel,Gustavo D, Y1 - 2019/06/27/ PY - 2019/05/21/received PY - 2019/05/23/accepted PY - 2019/8/28/entrez KW - Handgrip strength KW - Hemodialysis KW - Lean body mass KW - Leucine KW - Muscle function KW - Protein SP - 290 EP - 293 JF - Clinical nutrition ESPEN JO - Clin Nutr ESPEN VL - 33 N2 - BACKGROUND & AIMS: Inadequate protein intake is associated with lean body mass (LBM) loss. However, it is unclear whether high protein diet and leucine intake are associated with handgrip strength (HGS), a validated marker of muscle function. This study aims to: i) assess the prevalence of patients with low HGS; and ii) verify if HGS is correlated with high protein diet and leucine consumption in hemodialysis patients. METHODS: This cross-sectional study analysed patients at two center hemodialysis (HD) clinic and sixty-two patients aged ∼39 years with length of time on HD ∼60 months undergoing HD was carried out. Body weight (kg), LBM (kg) and body fat mass (%) assessments were performed by dual-energy X-ray absorptiometry and height (m) through portable stadiometer. Body mass index (BMI) (kg/m2) was calculated using the body weight and height. HGS (kg) was measured using a hydraulic dynamometer. Fisher's exact test, Chi-square, Pearson's correlation, and logistic regression were done to test the hypothesis. RESULTS: Out of 62 patients, 47 (75.8%) presented low HGS. In addition, no correlation was found between protein intake (if in percentage or g/kg/d) and HGS (r = 0.07, p = 0.58; r = -0.04, p = 0.70, respectively). Although there is a low correlation among leucine intake (g/d) and HGS (r = 0.39, p = 0.01), low HGS was not associated with leucine intake in the crude model (OR: 0.86 95%CI(0.60-1.24) p = 0.441), nor after adjustment for age, sex and BMI (OR: 0.84 95%CI(0.56-1.26), p = 0.422). CONCLUSIONS: Approximately 75% of patients undergoing hemodialysis presented low HGS. Additionally, neither a high protein diet nor leucine intake was associated with the HGS values. SN - 2405-4577 UR - https://www.unboundmedicine.com/medline/citation/31451270/Total_protein_or_leucine_intakes_are_not_associated_with_handgrip_strength_in_hemodialysis_patients:_A_pilot_study L2 - https://linkinghub.elsevier.com/retrieve/pii/S2405-4577(19)30324-9 DB - PRIME DP - Unbound Medicine ER -