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The MicroRNA Expression Profile Differs Between Erythrodermic Mycosis Fungoides and Sézary Syndrome.
Acta Derm Venereol 2019; 99(12):1148-1153AD

Abstract

It is difficult to distinguish erythrodermic mycosis fungoides from Sézary syndrome due to their similar clinical and histological features. The main purpose of this study was to investigate whether microRNA expression profiles in lesional skin could discriminate patients with erythrodermic mycosis fungoides from those with Sézary syndrome. A further aim was to assess whether the microRNA expression profiles in erythrodermic mycosis fungoides skin was more comparable to microRNA expression profiles of Sézary syndrome or early-stage mycosis fungoides. RNA was extracted from diagnostic skin biopsies, followed by quantitative reverse transcription polymerase chain reaction analysis of 383 microRNAs. Twenty-seven microRNAs were significantly differentially expressed between erythro-dermic mycosis fungoides and Sézary syndrome. More-over, erythrodermic mycosis fungoides showed microRNA features overlapping with Sézary syndrome and early-stage mycosis fungoides, although hierarchical cluster analysis co-clustered erythrodermic mycosis fungoides with early-stage mycosis fungoides rather than with Sézary syndrome. These findings underscore that erythrodermic mycosis fungoides and Sézary syndrome are different diseases.

Authors+Show Affiliations

Department of Dermatology, Aarhus University Hospital, DK-8200 Aarhus N, Denmark. Annehald@clin.au.dk.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31453630

Citation

Rittig, Anne Hald, et al. "The MicroRNA Expression Profile Differs Between Erythrodermic Mycosis Fungoides and Sézary Syndrome." Acta Dermato-venereologica, vol. 99, no. 12, 2019, pp. 1148-1153.
Rittig AH, Lindahl LM, Johansen C, et al. The MicroRNA Expression Profile Differs Between Erythrodermic Mycosis Fungoides and Sézary Syndrome. Acta Derm Venereol. 2019;99(12):1148-1153.
Rittig, A. H., Lindahl, L. M., Johansen, C., Celis, P., Ødum, N., Iversen, L., & Litman, T. (2019). The MicroRNA Expression Profile Differs Between Erythrodermic Mycosis Fungoides and Sézary Syndrome. Acta Dermato-venereologica, 99(12), pp. 1148-1153. doi:10.2340/00015555-3306.
Rittig AH, et al. The MicroRNA Expression Profile Differs Between Erythrodermic Mycosis Fungoides and Sézary Syndrome. Acta Derm Venereol. 2019 Nov 1;99(12):1148-1153. PubMed PMID: 31453630.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The MicroRNA Expression Profile Differs Between Erythrodermic Mycosis Fungoides and Sézary Syndrome. AU - Rittig,Anne Hald, AU - Lindahl,Lise M, AU - Johansen,Claus, AU - Celis,Pamela, AU - Ødum,Niels, AU - Iversen,Lars, AU - Litman,Thomas, PY - 2019/8/28/pubmed PY - 2019/8/28/medline PY - 2019/8/28/entrez KW - mycosis fungoides, Sézary syndrome, cutaneous T cell lymphoma, microRNA SP - 1148 EP - 1153 JF - Acta dermato-venereologica JO - Acta Derm. Venereol. VL - 99 IS - 12 N2 - It is difficult to distinguish erythrodermic mycosis fungoides from Sézary syndrome due to their similar clinical and histological features. The main purpose of this study was to investigate whether microRNA expression profiles in lesional skin could discriminate patients with erythrodermic mycosis fungoides from those with Sézary syndrome. A further aim was to assess whether the microRNA expression profiles in erythrodermic mycosis fungoides skin was more comparable to microRNA expression profiles of Sézary syndrome or early-stage mycosis fungoides. RNA was extracted from diagnostic skin biopsies, followed by quantitative reverse transcription polymerase chain reaction analysis of 383 microRNAs. Twenty-seven microRNAs were significantly differentially expressed between erythro-dermic mycosis fungoides and Sézary syndrome. More-over, erythrodermic mycosis fungoides showed microRNA features overlapping with Sézary syndrome and early-stage mycosis fungoides, although hierarchical cluster analysis co-clustered erythrodermic mycosis fungoides with early-stage mycosis fungoides rather than with Sézary syndrome. These findings underscore that erythrodermic mycosis fungoides and Sézary syndrome are different diseases. SN - 1651-2057 UR - https://www.unboundmedicine.com/medline/citation/31453630/The_MicroRNA_Expression_Profile_Differs_Between_Erythrodermic_Mycosis_Fungoides_and_Sézary_Syndrome_ L2 - https://www.medicaljournals.se/acta/content/abstract/10.2340/00015555-3306 DB - PRIME DP - Unbound Medicine ER -