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Molecular and Clinical Comparison of Enterovirus D68 Outbreaks among Hospitalized Children, Ohio, USA, 2014 and 2018.
Emerg Infect Dis. 2019 11; 25(11):2055-2063.EI

Abstract

Enterovirus D68 (EV-D68) causes respiratory tract infections and neurologic manifestations. We compared the clinical manifestations from 2 EV-D68 outbreaks in 2014 and 2018 and a low-activity period in 2016 among hospitalized children in central Ohio, USA, and used PCR and sequencing to enable phylogenetic comparisons. During both outbreak periods, infected children had respiratory manifestations that led to an increase in hospital admissions for asthma. The 2018 EV-D68 outbreak appeared to be milder in terms of respiratory illness, as shown by lower rates of pediatric intensive care unit admission. However, the frequency of severe neurologic manifestations was higher in 2018 than in 2014. During the same period in 2016, we noted neither an increase in EV-D68 nor a significant increase in asthma-related admissions. Phylogenetic analyses showed that EV-D68 isolates from 2018 clustered differently within clade B than did isolates from 2014 and are perhaps associated with a different EV-D68 subclade.

Authors

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Pub Type(s)

Historical Article
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31454311

Citation

Wang, Huanyu, et al. "Molecular and Clinical Comparison of Enterovirus D68 Outbreaks Among Hospitalized Children, Ohio, USA, 2014 and 2018." Emerging Infectious Diseases, vol. 25, no. 11, 2019, pp. 2055-2063.
Wang H, Diaz A, Moyer K, et al. Molecular and Clinical Comparison of Enterovirus D68 Outbreaks among Hospitalized Children, Ohio, USA, 2014 and 2018. Emerg Infect Dis. 2019;25(11):2055-2063.
Wang, H., Diaz, A., Moyer, K., Mele-Casas, M., Ara-Montojo, M. F., Torrus, I., McCoy, K., Mejias, A., & Leber, A. L. (2019). Molecular and Clinical Comparison of Enterovirus D68 Outbreaks among Hospitalized Children, Ohio, USA, 2014 and 2018. Emerging Infectious Diseases, 25(11), 2055-2063. https://doi.org/10.3201/eid2511.190973
Wang H, et al. Molecular and Clinical Comparison of Enterovirus D68 Outbreaks Among Hospitalized Children, Ohio, USA, 2014 and 2018. Emerg Infect Dis. 2019;25(11):2055-2063. PubMed PMID: 31454311.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular and Clinical Comparison of Enterovirus D68 Outbreaks among Hospitalized Children, Ohio, USA, 2014 and 2018. AU - Wang,Huanyu, AU - Diaz,Alejandro, AU - Moyer,Katherine, AU - Mele-Casas,Maria, AU - Ara-Montojo,Maria Fatima, AU - Torrus,Isabel, AU - McCoy,Karen, AU - Mejias,Asuncion, AU - Leber,Amy L, Y1 - 2019/11/17/ PY - 2019/8/28/pubmed PY - 2020/4/9/medline PY - 2019/8/28/entrez KW - EV-D68 KW - Enterovirus D68 KW - Ohio KW - United States KW - acute flaccid myelitis KW - asthma KW - children KW - molecular detection KW - pediatric KW - viruses SP - 2055 EP - 2063 JF - Emerging infectious diseases JO - Emerg Infect Dis VL - 25 IS - 11 N2 - Enterovirus D68 (EV-D68) causes respiratory tract infections and neurologic manifestations. We compared the clinical manifestations from 2 EV-D68 outbreaks in 2014 and 2018 and a low-activity period in 2016 among hospitalized children in central Ohio, USA, and used PCR and sequencing to enable phylogenetic comparisons. During both outbreak periods, infected children had respiratory manifestations that led to an increase in hospital admissions for asthma. The 2018 EV-D68 outbreak appeared to be milder in terms of respiratory illness, as shown by lower rates of pediatric intensive care unit admission. However, the frequency of severe neurologic manifestations was higher in 2018 than in 2014. During the same period in 2016, we noted neither an increase in EV-D68 nor a significant increase in asthma-related admissions. Phylogenetic analyses showed that EV-D68 isolates from 2018 clustered differently within clade B than did isolates from 2014 and are perhaps associated with a different EV-D68 subclade. SN - 1080-6059 UR - https://www.unboundmedicine.com/medline/citation/31454311/Molecular_and_Clinical_Comparison_of_Enterovirus_D68_Outbreaks_among_Hospitalized_Children_Ohio_USA_2014_and_2018_ L2 - https://doi.org/10.3201/eid2511.190973 DB - PRIME DP - Unbound Medicine ER -