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[Behavior of basal and stimulated serum levels of prolactin, growth hormone and gonadotropins in females with chronic uremia].
Z Gesamte Inn Med. 1988 Oct 01; 43(19):542-4.ZG

Abstract

In 11 female patients with chronic uraemia at the age of 20 to 47 years (average age: 33.1 years) the behaviour of basal and stimulated serum levels of prolactin (PRL), growth hormone (HGH) and gonadotropins (LH, FSH) was investigated. For stimulation of the hormone secretion a sequential test with arginine hydrochloride, gonadotropin releasing hormone (GnRH) and thyrotropin releasing hormone (TRH) was used. In 2 women the investigations were repeated after kidney transplantation. The determination of LH, FSH, PRL and HGH was performed radioimmunologically. The investigations show that in women with chronic uraemia the basal LH-levels in general lie clearly above of those ones of women with biphasic cycles, whereas the FSH-levels are not increased. The LH-response after administration of 25 micrograms GnRH is adequate in 6 women and is absent in 5 women. After kidney transplantation a clear reduction of the basal LH-levels in comparison to the preliminary values is to be established. The increased basal LH-levels are causally made responsible for the disturbances of the menstrual cycle in women with chronic uraemia. For PRL hyper- and normoprolactinaemic as well as hypoprolactinaemic basal levels are found. A connection between the height of the PRL and creatinine levels cannot be proved. Apart from a adequate PRL response to the stimulation with TRH in the individual case this response is inadequate or is absent. The basal HGH-levels are in the area of reference. In all women HGH can adequately be stimulated, whereby the case in question is presumably a so-called paradoxical TRH-effect.

Authors+Show Affiliations

Klinik für Gynäkologie und Geburtshilfe, Bereiches Medizin der Wilhelm-Pieck-Universität Rostock.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ger

PubMed ID

3145648

Citation

Rudolf, K, et al. "[Behavior of Basal and Stimulated Serum Levels of Prolactin, Growth Hormone and Gonadotropins in Females With Chronic Uremia]." Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete, vol. 43, no. 19, 1988, pp. 542-4.
Rudolf K, Rudolf H, Rüting M, et al. [Behavior of basal and stimulated serum levels of prolactin, growth hormone and gonadotropins in females with chronic uremia]. Z Gesamte Inn Med. 1988;43(19):542-4.
Rudolf, K., Rudolf, H., Rüting, M., & Falkenhagen, D. (1988). [Behavior of basal and stimulated serum levels of prolactin, growth hormone and gonadotropins in females with chronic uremia]. Zeitschrift Fur Die Gesamte Innere Medizin Und Ihre Grenzgebiete, 43(19), 542-4.
Rudolf K, et al. [Behavior of Basal and Stimulated Serum Levels of Prolactin, Growth Hormone and Gonadotropins in Females With Chronic Uremia]. Z Gesamte Inn Med. 1988 Oct 1;43(19):542-4. PubMed PMID: 3145648.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Behavior of basal and stimulated serum levels of prolactin, growth hormone and gonadotropins in females with chronic uremia]. AU - Rudolf,K, AU - Rudolf,H, AU - Rüting,M, AU - Falkenhagen,D, PY - 1988/10/1/pubmed PY - 1988/10/1/medline PY - 1988/10/1/entrez SP - 542 EP - 4 JF - Zeitschrift fur die gesamte innere Medizin und ihre Grenzgebiete JO - Z Gesamte Inn Med VL - 43 IS - 19 N2 - In 11 female patients with chronic uraemia at the age of 20 to 47 years (average age: 33.1 years) the behaviour of basal and stimulated serum levels of prolactin (PRL), growth hormone (HGH) and gonadotropins (LH, FSH) was investigated. For stimulation of the hormone secretion a sequential test with arginine hydrochloride, gonadotropin releasing hormone (GnRH) and thyrotropin releasing hormone (TRH) was used. In 2 women the investigations were repeated after kidney transplantation. The determination of LH, FSH, PRL and HGH was performed radioimmunologically. The investigations show that in women with chronic uraemia the basal LH-levels in general lie clearly above of those ones of women with biphasic cycles, whereas the FSH-levels are not increased. The LH-response after administration of 25 micrograms GnRH is adequate in 6 women and is absent in 5 women. After kidney transplantation a clear reduction of the basal LH-levels in comparison to the preliminary values is to be established. The increased basal LH-levels are causally made responsible for the disturbances of the menstrual cycle in women with chronic uraemia. For PRL hyper- and normoprolactinaemic as well as hypoprolactinaemic basal levels are found. A connection between the height of the PRL and creatinine levels cannot be proved. Apart from a adequate PRL response to the stimulation with TRH in the individual case this response is inadequate or is absent. The basal HGH-levels are in the area of reference. In all women HGH can adequately be stimulated, whereby the case in question is presumably a so-called paradoxical TRH-effect. SN - 0044-2542 UR - https://www.unboundmedicine.com/medline/citation/3145648/[Behavior_of_basal_and_stimulated_serum_levels_of_prolactin_growth_hormone_and_gonadotropins_in_females_with_chronic_uremia]_ L2 - https://medlineplus.gov/kidneyfailure.html DB - PRIME DP - Unbound Medicine ER -