Tags

Type your tag names separated by a space and hit enter

Molecular Mechanisms of Complement System Proteins and Matrix Metalloproteinases in the Pathogenesis of Age-Related Macular Degeneration.
Curr Mol Med. 2019; 19(10):705-718.CM

Abstract

Age-related macular degeneration (AMD) is an eye disorder affecting predominantly the older people above the age of 50 years in which the macular region of the retina deteriorates, resulting in the loss of central vision. The key factors associated with the pathogenesis of AMD are age, smoking, dietary, and genetic risk factors. There are few associated and plausible genes involved in AMD pathogenesis. Common genetic variants (with a minor allele frequency of >5% in the population) near the complement genes explain 40-60% of the heritability of AMD. The complement system is a group of proteins that work together to destroy foreign invaders, trigger inflammation, and remove debris from cells and tissues. Genetic changes in and around several complement system genes, including the CFH, contribute to the formation of drusen and progression of AMD. Similarly, Matrix metalloproteinases (MMPs) that are normally involved in tissue remodeling also play a critical role in the pathogenesis of AMD. MMPs are involved in the degradation of cell debris and lipid deposits beneath retina but with age their functions get affected and result in the drusen formation, succeeding to macular degeneration. In this review, AMD pathology, existing knowledge about the normal and pathological role of complement system proteins and MMPs in the eye is reviewed. The scattered data of complement system proteins, MMPs, drusenogenesis, and lipofusogenesis have been gathered and discussed in detail. This might add new dimensions to the understanding of molecular mechanisms of AMD pathophysiology and might help in finding new therapeutic options for AMD.

Authors+Show Affiliations

Department of Biotechnology, COMSATS University Islamabad, Abbottabad Campus, 22060, Pakistan.Department of Biotechnology, COMSATS University Islamabad, Abbottabad Campus, 22060, Pakistan.Department of Biosciences, COMSATS University Islamabad, Pakistan.Department of Biotechnology, COMSATS University Islamabad, Abbottabad Campus, 22060, Pakistan.Department of Ophthalmology, Radboud University Nijmegen Medical Centre, Nijmegen, Netherlands.Department of Biosciences, COMSATS University Islamabad, Pakistan.Department of Biotechnology, COMSATS University Islamabad, Abbottabad Campus, 22060, Pakistan.

Pub Type(s)

Journal Article
Review
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31456517

Citation

Mansoor, Naima, et al. "Molecular Mechanisms of Complement System Proteins and Matrix Metalloproteinases in the Pathogenesis of Age-Related Macular Degeneration." Current Molecular Medicine, vol. 19, no. 10, 2019, pp. 705-718.
Mansoor N, Wahid F, Azam M, et al. Molecular Mechanisms of Complement System Proteins and Matrix Metalloproteinases in the Pathogenesis of Age-Related Macular Degeneration. Curr Mol Med. 2019;19(10):705-718.
Mansoor, N., Wahid, F., Azam, M., Shah, K., den Hollander, A. I., Qamar, R., & Ayub, H. (2019). Molecular Mechanisms of Complement System Proteins and Matrix Metalloproteinases in the Pathogenesis of Age-Related Macular Degeneration. Current Molecular Medicine, 19(10), 705-718. https://doi.org/10.2174/1566524019666190828150625
Mansoor N, et al. Molecular Mechanisms of Complement System Proteins and Matrix Metalloproteinases in the Pathogenesis of Age-Related Macular Degeneration. Curr Mol Med. 2019;19(10):705-718. PubMed PMID: 31456517.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular Mechanisms of Complement System Proteins and Matrix Metalloproteinases in the Pathogenesis of Age-Related Macular Degeneration. AU - Mansoor,Naima, AU - Wahid,Fazli, AU - Azam,Maleeha, AU - Shah,Khadim, AU - den Hollander,Anneke I, AU - Qamar,Raheel, AU - Ayub,Humaira, PY - 2019/01/24/received PY - 2019/08/06/revised PY - 2019/08/09/accepted PY - 2019/8/29/pubmed PY - 2019/8/29/medline PY - 2019/8/29/entrez KW - AMD therapeutics KW - Higher age diseases KW - complement involvement in AMD KW - drusen formation KW - genetics based pathogenesis KW - matrix metalloproteinases. SP - 705 EP - 718 JF - Current molecular medicine JO - Curr Mol Med VL - 19 IS - 10 N2 - Age-related macular degeneration (AMD) is an eye disorder affecting predominantly the older people above the age of 50 years in which the macular region of the retina deteriorates, resulting in the loss of central vision. The key factors associated with the pathogenesis of AMD are age, smoking, dietary, and genetic risk factors. There are few associated and plausible genes involved in AMD pathogenesis. Common genetic variants (with a minor allele frequency of >5% in the population) near the complement genes explain 40-60% of the heritability of AMD. The complement system is a group of proteins that work together to destroy foreign invaders, trigger inflammation, and remove debris from cells and tissues. Genetic changes in and around several complement system genes, including the CFH, contribute to the formation of drusen and progression of AMD. Similarly, Matrix metalloproteinases (MMPs) that are normally involved in tissue remodeling also play a critical role in the pathogenesis of AMD. MMPs are involved in the degradation of cell debris and lipid deposits beneath retina but with age their functions get affected and result in the drusen formation, succeeding to macular degeneration. In this review, AMD pathology, existing knowledge about the normal and pathological role of complement system proteins and MMPs in the eye is reviewed. The scattered data of complement system proteins, MMPs, drusenogenesis, and lipofusogenesis have been gathered and discussed in detail. This might add new dimensions to the understanding of molecular mechanisms of AMD pathophysiology and might help in finding new therapeutic options for AMD. SN - 1875-5666 UR - https://www.unboundmedicine.com/medline/citation/31456517/Molecular_Mechanisms_of_Complement_System_Proteins_and_Matrix_Metalloproteinases_in_the_Pathogenesis_of_Age_Related_Macular_Degeneration_ L2 - http://www.eurekaselect.com/174508/article DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.