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Plant-Derived Tandem Drug/Mesoporous Silicon Microcarrier Structures for Anti-Inflammatory Therapy.
ACS Omega 2019; 4(5):8359-8364AO

Abstract

The properties of nanostructured plant-derived porous silicon (pSi) microparticles as potential candidates to increase the bioavailability of plant extracts possessing anti-inflammatory activity are described in this work. pSi drug carriers were fabricated using an eco-friendly route from the silicon accumulator plant bamboo (tabasheer) powder by magnesiothermic reduction of plant-derived silica and loaded with ethanolic extracts of Equisetum arvense, another silicon accumulator plant rich in polyphenolic compounds. The anti-inflammatory properties of the active therapeutics present in this extract were measured by sensitive luciferase reporter assays; this active extract was subsequently loaded and released from the pSi matrix, with a clear inhibition of the activity of the inflammatory signaling protein NF-κB over a period of hours in a sustained manner. Our results showed that after loading the extracts of E. arvense into pSi microparticles derived from tabasheer, enhanced anti-inflammatory activity was observed owing to enhanced solubility of the extract.

Authors+Show Affiliations

Department of Chemistry and Biochemistry and Department of Biology, Texas Christian University, Fort Worth, Texas 76129, United States.Department of Chemistry and Biochemistry and Department of Biology, Texas Christian University, Fort Worth, Texas 76129, United States.Department of Chemistry and Biochemistry and Department of Biology, Texas Christian University, Fort Worth, Texas 76129, United States.Nanoscale Physics, Chemistry, and Engineering Research Laboratory, University of Birmingham, Birmingham B15 2TT, U.K.Nanoscale Physics, Chemistry, and Engineering Research Laboratory, University of Birmingham, Birmingham B15 2TT, U.K.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31459924

Citation

Kalluri, Jhansi R., et al. "Plant-Derived Tandem Drug/Mesoporous Silicon Microcarrier Structures for Anti-Inflammatory Therapy." ACS Omega, vol. 4, no. 5, 2019, pp. 8359-8364.
Kalluri JR, West J, Akkaraju GR, et al. Plant-Derived Tandem Drug/Mesoporous Silicon Microcarrier Structures for Anti-Inflammatory Therapy. ACS Omega. 2019;4(5):8359-8364.
Kalluri, J. R., West, J., Akkaraju, G. R., Canham, L. T., & Coffer, J. L. (2019). Plant-Derived Tandem Drug/Mesoporous Silicon Microcarrier Structures for Anti-Inflammatory Therapy. ACS Omega, 4(5), pp. 8359-8364. doi:10.1021/acsomega.9b00127.
Kalluri JR, et al. Plant-Derived Tandem Drug/Mesoporous Silicon Microcarrier Structures for Anti-Inflammatory Therapy. ACS Omega. 2019 May 31;4(5):8359-8364. PubMed PMID: 31459924.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plant-Derived Tandem Drug/Mesoporous Silicon Microcarrier Structures for Anti-Inflammatory Therapy. AU - Kalluri,Jhansi R, AU - West,Julianna, AU - Akkaraju,Giridhar R, AU - Canham,Leigh T, AU - Coffer,Jeffery L, Y1 - 2019/05/09/ PY - 2019/01/14/received PY - 2019/04/15/accepted PY - 2019/8/29/entrez PY - 2019/8/29/pubmed PY - 2019/8/29/medline SP - 8359 EP - 8364 JF - ACS omega JO - ACS Omega VL - 4 IS - 5 N2 - The properties of nanostructured plant-derived porous silicon (pSi) microparticles as potential candidates to increase the bioavailability of plant extracts possessing anti-inflammatory activity are described in this work. pSi drug carriers were fabricated using an eco-friendly route from the silicon accumulator plant bamboo (tabasheer) powder by magnesiothermic reduction of plant-derived silica and loaded with ethanolic extracts of Equisetum arvense, another silicon accumulator plant rich in polyphenolic compounds. The anti-inflammatory properties of the active therapeutics present in this extract were measured by sensitive luciferase reporter assays; this active extract was subsequently loaded and released from the pSi matrix, with a clear inhibition of the activity of the inflammatory signaling protein NF-κB over a period of hours in a sustained manner. Our results showed that after loading the extracts of E. arvense into pSi microparticles derived from tabasheer, enhanced anti-inflammatory activity was observed owing to enhanced solubility of the extract. SN - 2470-1343 UR - https://www.unboundmedicine.com/medline/citation/31459924/Plant-Derived_Tandem_Drug/Mesoporous_Silicon_Microcarrier_Structures_for_Anti-Inflammatory_Therapy L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/31459924/ DB - PRIME DP - Unbound Medicine ER -