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Current understanding of tumor lysis syndrome.

Abstract

Tumor lysis syndrome (TLS) is an oncologic emergency from the intracellular release of material in lysing malignant cells. The earlier it is treated, the less likely it is to be harmful to an individual and spread through the body. Common complications of TLS include arrhythmias, which are caused by hypocalcemia or hyperkalemia, renal failures due to hyperuricemia or hyperphosphatemia, and seizures. Furthermore, the risk to develop TLS varies widely based on several factors including factors that are related to disease, the patient, and the treatment of the patient. Laboratory data can be used to gauge the severity of TLS based on patient serum levels for specific markers. On the contrary, evidence of TLS via radiological imaging and electrocardiogram findings has been a limited way to evaluate TLS, indicating the need for further research in this area. Common trends of treatment have also been seen in the past several years, evident by case studies seen in the following literature review.

Authors+Show Affiliations

Department of Physiology and Biophysics, Stony Brook University Renaissance School of Medicine, Stony Brook, New York.Department of Physiology and Biophysics, Stony Brook University Renaissance School of Medicine, Stony Brook, New York.Department of Physiology and Biophysics, Stony Brook University Renaissance School of Medicine, Stony Brook, New York.Department of Physiology and Biophysics, Stony Brook University Renaissance School of Medicine, Stony Brook, New York. Medical Student Research Institute, St. George's University School of Medicine, Grenada, West Indies, Grenada.Department of Physiology and Biophysics, Stony Brook University Renaissance School of Medicine, Stony Brook, New York.Foley Plaza Medical, New York, New York.Department of Physiology and Biophysics, Stony Brook University Renaissance School of Medicine, Stony Brook, New York. Department of Urology, Stony Brook University Renaissance School of Medicine, Stony Brook, New York.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

31461568

Citation

Rahmani, Benjamin, et al. "Current Understanding of Tumor Lysis Syndrome." Hematological Oncology, 2019.
Rahmani B, Patel S, Seyam O, et al. Current understanding of tumor lysis syndrome. Hematol Oncol. 2019.
Rahmani, B., Patel, S., Seyam, O., Gandhi, J., Reid, I., Smith, N., & Khan, S. A. (2019). Current understanding of tumor lysis syndrome. Hematological Oncology, doi:10.1002/hon.2668.
Rahmani B, et al. Current Understanding of Tumor Lysis Syndrome. Hematol Oncol. 2019 Aug 28; PubMed PMID: 31461568.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Current understanding of tumor lysis syndrome. AU - Rahmani,Benjamin, AU - Patel,Shrey, AU - Seyam,Omar, AU - Gandhi,Jason, AU - Reid,Inefta, AU - Smith,Noel, AU - Khan,Sardar Ali, Y1 - 2019/08/28/ PY - 2018/10/23/received PY - 2019/08/15/revised PY - 2019/08/22/accepted PY - 2019/8/29/pubmed PY - 2019/8/29/medline PY - 2019/8/29/entrez KW - allopurinol KW - hyperkalemia KW - hyperphosphatemia KW - hyperuricemia KW - hypocalcemia KW - rasburicase KW - tumor lysis syndrome JF - Hematological oncology JO - Hematol Oncol N2 - Tumor lysis syndrome (TLS) is an oncologic emergency from the intracellular release of material in lysing malignant cells. The earlier it is treated, the less likely it is to be harmful to an individual and spread through the body. Common complications of TLS include arrhythmias, which are caused by hypocalcemia or hyperkalemia, renal failures due to hyperuricemia or hyperphosphatemia, and seizures. Furthermore, the risk to develop TLS varies widely based on several factors including factors that are related to disease, the patient, and the treatment of the patient. Laboratory data can be used to gauge the severity of TLS based on patient serum levels for specific markers. On the contrary, evidence of TLS via radiological imaging and electrocardiogram findings has been a limited way to evaluate TLS, indicating the need for further research in this area. Common trends of treatment have also been seen in the past several years, evident by case studies seen in the following literature review. SN - 1099-1069 UR - https://www.unboundmedicine.com/medline/citation/31461568/Current_understanding_of_tumor_lysis_syndrome L2 - https://doi.org/10.1002/hon.2668 DB - PRIME DP - Unbound Medicine ER -