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Influence of Obesity on Work Ability, Respiratory Symptoms, and Lung Function in Adults with Asthma.
Respiration 2019; :1-9R

Abstract

BACKGROUND

Asthma is defined by variable respiratory symptoms and lung function, and may influence work ability. Similarly, obesity may contribute to respiratory symptoms, affect lung function, and reduce work ability. Thus, assessment of the influence of obesity on work ability, respiratory symptoms, and lung function in adults with asthma is needed.

OBJECTIVES

We hypothesized that patients with obesity and asthma have more respiratory symptoms and reduced work ability and lung function compared with normal-weight patients with asthma.

METHODS

We examined 626 participants with physician-diagnosed asthma, aged 18-52 years, recruited from a cross-sectional general population study using a comprehensive questionnaire including work ability score, the asthma control test (ACT), height and weight, and spirometry with reversibility testing.

RESULTS

Participants with a body mass index (BMI) ≥30 kg/m2 (i.e., obese) had a higher symptom score (OR 1.78, 95% CI 1.14-2.80), current use of asthma medication (1.60, 1.05-2.46), and incidence of ACT scores ≤19 (poor asthma control) (1.81, 1.03-3.18) than participants with BMI ≤24.9 kg/m2 (i.e., normal weight). Post-bronchodilator forced vital capacity (FVC) as a percentage of predicted (β coefficient -4.5) and pre-bronchodilator forced expiratory volume in 1 s as a percentage of predicted (FEV1) (β coefficient -4.6) were negatively associated with BMI ≥30 kg/m2. We found no statistically significant association of BMI >30 kg/m2 (compared to BMI <24.9 kg/m2) with sick leave (1.21, 0.75-1.70) or reduced work ability (1.23, 0.74-2.04).

CONCLUSIONS

There were indications that patients with obesity had a higher symptom burden, poorer asthma control, higher consumption of asthma medication, and reduced lung function, in particular for FVC, compared with normal-weight patients.

Authors+Show Affiliations

Department of Occupational and Environmental Medicine, Telemark Hospital, Skien, Norway, geir.klepaker@sthf.no. Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway, geir.klepaker@sthf.no.Department of Occupational and Environmental Medicine, Telemark Hospital, Skien, Norway.Morbid Obesity Center, Vestfold Hospital Trust, Tønsberg, Norway.Department of Laboratory Medicine, Section of Medical Genetics, Telemark Hospital, Skien, Norway.Respiratory Health Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Morgantown, West Virginia, USA.Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. Department of Respiratory Medicine, Oslo University Hospital, Oslo, Norway.Department of Occupational and Environmental Medicine, Telemark Hospital, Skien, Norway.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31461714

Citation

Klepaker, Geir, et al. "Influence of Obesity On Work Ability, Respiratory Symptoms, and Lung Function in Adults With Asthma." Respiration; International Review of Thoracic Diseases, 2019, pp. 1-9.
Klepaker G, Svendsen MV, Hertel JK, et al. Influence of Obesity on Work Ability, Respiratory Symptoms, and Lung Function in Adults with Asthma. Respiration. 2019.
Klepaker, G., Svendsen, M. V., Hertel, J. K., Holla, Ø. L., Henneberger, P. K., Kongerud, J., & Fell, A. K. M. (2019). Influence of Obesity on Work Ability, Respiratory Symptoms, and Lung Function in Adults with Asthma. Respiration; International Review of Thoracic Diseases, pp. 1-9. doi:10.1159/000502154.
Klepaker G, et al. Influence of Obesity On Work Ability, Respiratory Symptoms, and Lung Function in Adults With Asthma. Respiration. 2019 Aug 28;1-9. PubMed PMID: 31461714.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of Obesity on Work Ability, Respiratory Symptoms, and Lung Function in Adults with Asthma. AU - Klepaker,Geir, AU - Svendsen,Martin Veel, AU - Hertel,Jens Kristoffer, AU - Holla,Øystein Lunde, AU - Henneberger,Paul Keefer, AU - Kongerud,Johny, AU - Fell,Anne Kristin Møller, Y1 - 2019/08/28/ PY - 2019/03/26/received PY - 2019/07/16/accepted PY - 2019/8/29/entrez PY - 2019/8/29/pubmed PY - 2019/8/29/medline KW - Asthma KW - Lung function KW - Obesity KW - Respiratory symptoms KW - Work ability SP - 1 EP - 9 JF - Respiration; international review of thoracic diseases JO - Respiration N2 - BACKGROUND: Asthma is defined by variable respiratory symptoms and lung function, and may influence work ability. Similarly, obesity may contribute to respiratory symptoms, affect lung function, and reduce work ability. Thus, assessment of the influence of obesity on work ability, respiratory symptoms, and lung function in adults with asthma is needed. OBJECTIVES: We hypothesized that patients with obesity and asthma have more respiratory symptoms and reduced work ability and lung function compared with normal-weight patients with asthma. METHODS: We examined 626 participants with physician-diagnosed asthma, aged 18-52 years, recruited from a cross-sectional general population study using a comprehensive questionnaire including work ability score, the asthma control test (ACT), height and weight, and spirometry with reversibility testing. RESULTS: Participants with a body mass index (BMI) ≥30 kg/m2 (i.e., obese) had a higher symptom score (OR 1.78, 95% CI 1.14-2.80), current use of asthma medication (1.60, 1.05-2.46), and incidence of ACT scores ≤19 (poor asthma control) (1.81, 1.03-3.18) than participants with BMI ≤24.9 kg/m2 (i.e., normal weight). Post-bronchodilator forced vital capacity (FVC) as a percentage of predicted (β coefficient -4.5) and pre-bronchodilator forced expiratory volume in 1 s as a percentage of predicted (FEV1) (β coefficient -4.6) were negatively associated with BMI ≥30 kg/m2. We found no statistically significant association of BMI >30 kg/m2 (compared to BMI <24.9 kg/m2) with sick leave (1.21, 0.75-1.70) or reduced work ability (1.23, 0.74-2.04). CONCLUSIONS: There were indications that patients with obesity had a higher symptom burden, poorer asthma control, higher consumption of asthma medication, and reduced lung function, in particular for FVC, compared with normal-weight patients. SN - 1423-0356 UR - https://www.unboundmedicine.com/medline/citation/31461714/Influence_of_Obesity_on_Work_Ability,_Respiratory_Symptoms,_and_Lung_Function_in_Adults_with_Asthma L2 - https://www.karger.com?DOI=10.1159/000502154 DB - PRIME DP - Unbound Medicine ER -