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Parvovirus B19 infection presenting with neutropenia and thrombocytopenia: Three case reports.
Medicine (Baltimore) 2019; 98(35):e16993M

Abstract

RATIONALE

Parvovirus B19 (PV) infection is usually symptomless and can cause benign, short-lived conditions. Anemia associated with PRCA is the most representative hematologic manifestation, but neutropenia and thrombocytopenia have been rarely reported.

PATIENT CONCERNS

Three patients were admitted to the hospital with neutropenia and thrombocytopenia. The accompanying symptoms were fever, myalgia, rash, or arthralgia, and all patients were previously healthy.

DIAGNOSIS

Patients were positive for PV PCR and diagnosed with PV infection. Before the diagnosis of PV infection, 2 patients underwent BM study and almost absence of erythroid progenitor cells in BM aspiration were a clue for the PV infection. Other BM findings were hypocellular marrow and a few hemophagocytic histiocytes.

INTERVENTIONS

Patients received supportive care with follow-up of CBC.

OUTCOMES

All 3 patients spontaneously recovered from neutropenia and thrombocytopenia within 3 weeks without severe complications.

LESSONS

The evaluation of PV infection should be considered in situations where there is neutropenia and thrombocytopenia in healthy individuals even without anemia as a differential diagnosis.

Authors+Show Affiliations

Department of Laboratory Medicine.Division of Hematology-Oncology, Department of Internal Medicine Gyeongsang National University Hospital, Gyeongsang National University School of Medicine.Division of Hematology-Oncology, Department of Internal Medicine Gyeongsang National University Hospital, Gyeongsang National University School of Medicine. Institute of Health Science, Gyeongsang National University, Jinju.Department of Laboratory Medicine. Institute of Health Science, Gyeongsang National University, Jinju.Department of Laboratory Medicine & Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

31464949

Citation

Shin, Hyoshim, et al. "Parvovirus B19 Infection Presenting With Neutropenia and Thrombocytopenia: Three Case Reports." Medicine, vol. 98, no. 35, 2019, pp. e16993.
Shin H, Park S, Lee GW, et al. Parvovirus B19 infection presenting with neutropenia and thrombocytopenia: Three case reports. Medicine (Baltimore). 2019;98(35):e16993.
Shin, H., Park, S., Lee, G. W., Koh, E. H., & Kim, H. Y. (2019). Parvovirus B19 infection presenting with neutropenia and thrombocytopenia: Three case reports. Medicine, 98(35), pp. e16993. doi:10.1097/MD.0000000000016993.
Shin H, et al. Parvovirus B19 Infection Presenting With Neutropenia and Thrombocytopenia: Three Case Reports. Medicine (Baltimore). 2019;98(35):e16993. PubMed PMID: 31464949.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parvovirus B19 infection presenting with neutropenia and thrombocytopenia: Three case reports. AU - Shin,Hyoshim, AU - Park,Sungwoo, AU - Lee,Gyeong-Won, AU - Koh,Eun-Ha, AU - Kim,Hyun-Young, PY - 2019/8/30/entrez PY - 2019/8/30/pubmed PY - 2019/9/17/medline SP - e16993 EP - e16993 JF - Medicine JO - Medicine (Baltimore) VL - 98 IS - 35 N2 - RATIONALE: Parvovirus B19 (PV) infection is usually symptomless and can cause benign, short-lived conditions. Anemia associated with PRCA is the most representative hematologic manifestation, but neutropenia and thrombocytopenia have been rarely reported. PATIENT CONCERNS: Three patients were admitted to the hospital with neutropenia and thrombocytopenia. The accompanying symptoms were fever, myalgia, rash, or arthralgia, and all patients were previously healthy. DIAGNOSIS: Patients were positive for PV PCR and diagnosed with PV infection. Before the diagnosis of PV infection, 2 patients underwent BM study and almost absence of erythroid progenitor cells in BM aspiration were a clue for the PV infection. Other BM findings were hypocellular marrow and a few hemophagocytic histiocytes. INTERVENTIONS: Patients received supportive care with follow-up of CBC. OUTCOMES: All 3 patients spontaneously recovered from neutropenia and thrombocytopenia within 3 weeks without severe complications. LESSONS: The evaluation of PV infection should be considered in situations where there is neutropenia and thrombocytopenia in healthy individuals even without anemia as a differential diagnosis. SN - 1536-5964 UR - https://www.unboundmedicine.com/medline/citation/31464949/Parvovirus_B19_infection_presenting_with_neutropenia_and_thrombocytopenia:_Three_case_reports L2 - http://dx.doi.org/10.1097/MD.0000000000016993 DB - PRIME DP - Unbound Medicine ER -