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Glaucoma and Cornea Surgery Outcomes in Peters Anomaly.
Am J Ophthalmol. 2019 12; 208:367-375.AJ

Abstract

PURPOSE

To conduct a qualitative description of corneal and glaucoma outcomes in Peters anomaly.

DESIGN

Retrospective case series.

METHODS

Children with Peters anomaly who presented between 1982-2017 were included. Visual acuity, intraocular pressure (IOP), survival of corneal grafts, and success of glaucoma surgery (defined as IOP of 5-20 mm Hg and no additional IOP-lowering surgery or visually devastating complications) were analyzed.

RESULTS

Fifty-eight eyes of 37 patients (19 males) with Peters anomaly presented at 0.7 ± 1.5 years of age and had a follow-up of 10.2 ± 10.8 years. Twenty-three eyes underwent penetrating keratoplasty (PKP) with an average of 2.0 ± 1.3 grafts per eye. PKP survival at 1 year was 60% (95% confidence interval 41-75%) but decreased at 10 years to 34% (95% confidence interval 18-51%). Thirty-four eyes were diagnosed with glaucoma at 2.8 ± 6.4 years of age. Twenty eyes required glaucoma surgery, and the average number of IOP-lowering surgeries was 2.9 ± 2.0 per eye. Glaucoma drainage devices (15 eyes) had a 53% success rate. Laser cycloablation (9 eyes, transcleral or endoscopic) had a success rate of 67% with 2.0 ± 1.0 treatments per eye. Trabeculectomy with mitomycin C (8 eyes) and trabeculotomy (8 eyes) had 25% and 0% success rates, respectively. Fifteen eyes that underwent glaucoma surgery obtained IOP control, and GDD with or without cycloablation accounted for 80% of the successes. Eyes that underwent PKP did not show increased rates of glaucoma, higher IOP, or a greater necessity for IOP-lowering surgery.

CONCLUSIONS

In Peters anomaly, PKP shows poor long-term success. In addition, >50% of eyes with Peters anomaly have secondary glaucoma that often requires multiple surgeries.

Authors+Show Affiliations

Abrahamson Pediatric Eye Institute, Cincinnati Children's Hospital Medical Center, Department of Ophthalmology, University of Cincinnati, College of Medicine, Cincinnati, Ohio, USA.Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA.Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA.Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA.Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA.Kellogg Eye Center, Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, Michigan, USA. Electronic address: brendabo@med.umich.edu.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

31470000

Citation

Dolezal, Kara A., et al. "Glaucoma and Cornea Surgery Outcomes in Peters Anomaly." American Journal of Ophthalmology, vol. 208, 2019, pp. 367-375.
Dolezal KA, Besirli CG, Mian SI, et al. Glaucoma and Cornea Surgery Outcomes in Peters Anomaly. Am J Ophthalmol. 2019;208:367-375.
Dolezal, K. A., Besirli, C. G., Mian, S. I., Sugar, A., Moroi, S. E., & Bohnsack, B. L. (2019). Glaucoma and Cornea Surgery Outcomes in Peters Anomaly. American Journal of Ophthalmology, 208, 367-375. https://doi.org/10.1016/j.ajo.2019.08.012
Dolezal KA, et al. Glaucoma and Cornea Surgery Outcomes in Peters Anomaly. Am J Ophthalmol. 2019;208:367-375. PubMed PMID: 31470000.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glaucoma and Cornea Surgery Outcomes in Peters Anomaly. AU - Dolezal,Kara A, AU - Besirli,Cagri G, AU - Mian,Shahzad I, AU - Sugar,Alan, AU - Moroi,Sayoko E, AU - Bohnsack,Brenda L, Y1 - 2019/08/28/ PY - 2018/10/15/received PY - 2019/08/17/revised PY - 2019/08/19/accepted PY - 2019/8/31/pubmed PY - 2020/3/28/medline PY - 2019/8/31/entrez SP - 367 EP - 375 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 208 N2 - PURPOSE: To conduct a qualitative description of corneal and glaucoma outcomes in Peters anomaly. DESIGN: Retrospective case series. METHODS: Children with Peters anomaly who presented between 1982-2017 were included. Visual acuity, intraocular pressure (IOP), survival of corneal grafts, and success of glaucoma surgery (defined as IOP of 5-20 mm Hg and no additional IOP-lowering surgery or visually devastating complications) were analyzed. RESULTS: Fifty-eight eyes of 37 patients (19 males) with Peters anomaly presented at 0.7 ± 1.5 years of age and had a follow-up of 10.2 ± 10.8 years. Twenty-three eyes underwent penetrating keratoplasty (PKP) with an average of 2.0 ± 1.3 grafts per eye. PKP survival at 1 year was 60% (95% confidence interval 41-75%) but decreased at 10 years to 34% (95% confidence interval 18-51%). Thirty-four eyes were diagnosed with glaucoma at 2.8 ± 6.4 years of age. Twenty eyes required glaucoma surgery, and the average number of IOP-lowering surgeries was 2.9 ± 2.0 per eye. Glaucoma drainage devices (15 eyes) had a 53% success rate. Laser cycloablation (9 eyes, transcleral or endoscopic) had a success rate of 67% with 2.0 ± 1.0 treatments per eye. Trabeculectomy with mitomycin C (8 eyes) and trabeculotomy (8 eyes) had 25% and 0% success rates, respectively. Fifteen eyes that underwent glaucoma surgery obtained IOP control, and GDD with or without cycloablation accounted for 80% of the successes. Eyes that underwent PKP did not show increased rates of glaucoma, higher IOP, or a greater necessity for IOP-lowering surgery. CONCLUSIONS: In Peters anomaly, PKP shows poor long-term success. In addition, >50% of eyes with Peters anomaly have secondary glaucoma that often requires multiple surgeries. SN - 1879-1891 UR - https://www.unboundmedicine.com/medline/citation/31470000/Glaucoma_and_Cornea_Surgery_Outcomes_in_Peters_Anomaly_ DB - PRIME DP - Unbound Medicine ER -