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Total Serum Magnesium Levels and Calcium-To-Magnesium Ratio in Sickle Cell Disease.
Medicina (Kaunas). 2019 Aug 29; 55(9)M

Abstract

Background and objectives: Imbalance of calcium/magnesium ratio could lead to clinical complications in sickle cell disease (SCD). Low levels of magnesium have been associated with sickling, increased polymerization and vaso-occlusion (VOC) in sickle cell due to cell dehydration. The K-Cl cotransport plays a very important role in sickle cell dehydration and is inhibited by significantly increasing levels of magnesium. The study evaluated total serum magnesium levels and computed calcium/magnesium ratio in SCD patients and "healthy" controls. Materials and methods: The study was a case-control cross-sectional one, involving 120 SCD patients (79 Haemoglobin SS (HbSS)and 41 Haemoglobin SC (HbSC)) at the steady state and 48 "healthy" controls. Sera were prepared from whole blood samples (n = 168) and total magnesium and calcium measured using a Flame Atomic Absorption Spectrometer (Variant 240FS manufactured by VARIAN Australia Pty Ltd., Melbourne, VIC, Australia). Calcium/magnesium ratios were calculated in patients and the controls.

Results:

The prevalence of hypomagnesemia and hypocalcaemia among the SCD patients was observed to be 39.17% and 52.50% respectively, higher than the controls (4.17% and 22.92%, for hypomagnesemia and hypocalcaemia, respectively). Level of magnesium was significantly lower in the SCD patients compared to their healthy counterparts (p = 0.002). The magnesium level was further reduced in the HbSS patients but not significantly different from the HbSC patients (p = 0.584). calcium/magnesium ratio was significantly higher in the SCD patients (p = 0.031). Although calcium/magnesium ratio was higher in the HbSC patients compared to those with the HbSS genotype, the difference was not significant (p = 0.101).

Conclusion:

The study shows that magnesium homeostasis are altered in SCD patients, and their levels are lower in HbSS patients. Although calcium/magnesium ratio is significantly higher in SCD patients compared with controls, there is no significant difference between patients with HbSS and HbSC genotypes. Magnesium supplementation may be required in sickle cell patients.

Authors+Show Affiliations

Department of Physiology, School of Biomedical and Allied Health Sciences, University of Ghana, Accra 00233, Ghana. antwiboasiako@gmail.com.Department of Physiology, School of Biomedical and Allied Health Sciences, University of Ghana, Accra 00233, Ghana. Departments of Anaesthesia, School of Medicine and Dentistry, University of Ghana, Accra 00233, Ghana.Department of Physiology, School of Biomedical and Allied Health Sciences, University of Ghana, Accra 00233, Ghana. Departments of Anaesthesia, School of Medicine and Dentistry, University of Ghana, Accra 00233, Ghana.Department of Physiology, School of Biomedical and Allied Health Sciences, University of Ghana, Accra 00233, Ghana.Department of Physiology, School of Biomedical and Allied Health Sciences, University of Ghana, Accra 00233, Ghana.Department of Physiology, School of Biomedical and Allied Health Sciences, University of Ghana, Accra 00233, Ghana. Department of Internal Medicine, Korle-Bu Teaching Hospital Accra 00233, Ghana.Departments of Anaesthesia, School of Medicine and Dentistry, University of Ghana, Accra 00233, Ghana.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

31470666

Citation

Antwi-Boasiako, Charles, et al. "Total Serum Magnesium Levels and Calcium-To-Magnesium Ratio in Sickle Cell Disease." Medicina (Kaunas, Lithuania), vol. 55, no. 9, 2019.
Antwi-Boasiako C, Kusi-Mensah YA, Hayfron-Benjamin C, et al. Total Serum Magnesium Levels and Calcium-To-Magnesium Ratio in Sickle Cell Disease. Medicina (Kaunas). 2019;55(9).
Antwi-Boasiako, C., Kusi-Mensah, Y. A., Hayfron-Benjamin, C., Aryee, R., Dankwah, G. B., Kwawukume, L. A., & Darkwa, E. O. (2019). Total Serum Magnesium Levels and Calcium-To-Magnesium Ratio in Sickle Cell Disease. Medicina (Kaunas, Lithuania), 55(9). https://doi.org/10.3390/medicina55090547
Antwi-Boasiako C, et al. Total Serum Magnesium Levels and Calcium-To-Magnesium Ratio in Sickle Cell Disease. Medicina (Kaunas). 2019 Aug 29;55(9) PubMed PMID: 31470666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Total Serum Magnesium Levels and Calcium-To-Magnesium Ratio in Sickle Cell Disease. AU - Antwi-Boasiako,Charles, AU - Kusi-Mensah,Yaw A, AU - Hayfron-Benjamin,Charles, AU - Aryee,Robert, AU - Dankwah,Gifty Boatemaah, AU - Kwawukume,Lim Abla, AU - Darkwa,Ebenezer Owusu, Y1 - 2019/08/29/ PY - 2019/06/18/received PY - 2019/08/09/revised PY - 2019/08/27/accepted PY - 2019/9/1/entrez PY - 2019/9/1/pubmed PY - 2019/9/1/medline KW - calcium KW - cell dehydration KW - homeostasis KW - magnesium KW - sickle cell disease JF - Medicina (Kaunas, Lithuania) JO - Medicina (Kaunas) VL - 55 IS - 9 N2 - Background and objectives: Imbalance of calcium/magnesium ratio could lead to clinical complications in sickle cell disease (SCD). Low levels of magnesium have been associated with sickling, increased polymerization and vaso-occlusion (VOC) in sickle cell due to cell dehydration. The K-Cl cotransport plays a very important role in sickle cell dehydration and is inhibited by significantly increasing levels of magnesium. The study evaluated total serum magnesium levels and computed calcium/magnesium ratio in SCD patients and "healthy" controls. Materials and methods: The study was a case-control cross-sectional one, involving 120 SCD patients (79 Haemoglobin SS (HbSS)and 41 Haemoglobin SC (HbSC)) at the steady state and 48 "healthy" controls. Sera were prepared from whole blood samples (n = 168) and total magnesium and calcium measured using a Flame Atomic Absorption Spectrometer (Variant 240FS manufactured by VARIAN Australia Pty Ltd., Melbourne, VIC, Australia). Calcium/magnesium ratios were calculated in patients and the controls. Results: The prevalence of hypomagnesemia and hypocalcaemia among the SCD patients was observed to be 39.17% and 52.50% respectively, higher than the controls (4.17% and 22.92%, for hypomagnesemia and hypocalcaemia, respectively). Level of magnesium was significantly lower in the SCD patients compared to their healthy counterparts (p = 0.002). The magnesium level was further reduced in the HbSS patients but not significantly different from the HbSC patients (p = 0.584). calcium/magnesium ratio was significantly higher in the SCD patients (p = 0.031). Although calcium/magnesium ratio was higher in the HbSC patients compared to those with the HbSS genotype, the difference was not significant (p = 0.101). Conclusion: The study shows that magnesium homeostasis are altered in SCD patients, and their levels are lower in HbSS patients. Although calcium/magnesium ratio is significantly higher in SCD patients compared with controls, there is no significant difference between patients with HbSS and HbSC genotypes. Magnesium supplementation may be required in sickle cell patients. SN - 1648-9144 UR - https://www.unboundmedicine.com/medline/citation/31470666/Total_Serum_Magnesium_Levels_and_Calcium_To_Magnesium_Ratio_in_Sickle_Cell_Disease_ L2 - https://www.mdpi.com/resolver?pii=medicina55090547 DB - PRIME DP - Unbound Medicine ER -
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