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Association of urinary concentrations of early pregnancy phthalate metabolites and bisphenol A with length of gestation.
Environ Health. 2019 08 30; 18(1):80.EH

Abstract

BACKGROUND

Environmental exposure to phthalates and bisphenol A (BPA) may have endocrine disrupting effects that alter length of gestation. We assessed the association between the urinary concentrations of 11 phthalate metabolites and BPA with length of gestation in a cohort of women followed from before conception with daily 1st-morning urinary hormone measures that identified day of implantation.

METHODS

Pre-implantation and post-implantation urinary phthalate metabolites and BPA concentrations were measured in pooled urine samples designed to limit single-measure variability due to the likely episodic nature of these exposures and the short half-life of these compounds. We estimated associations between these exposure biomarkers early in pregnancy with length of gestation from implantation to spontaneous birth. Cox proportional hazards models were used to estimate the hazard of birth among 125 naturally-conceived, singleton live births with censoring for medical interventions that artificially shortened pregnancy.

RESULTS

Higher concentrations of mono (2-ethyl-5-hydroxyhexyl) phthalate (a metabolite of di (2-ethylhexyl) phthalate (DEHP)) during the pre-implantation window were associated with reduced probability of birth, i.e., longer gestations (hazard ratio (HR): 0.55, 95% CI: 0.35, 0.86; p = 0.01). The HR for the molar sum of the four DEHP metabolites measured showed a similar association (HR: 0.67, 95% CI: 0.43, 1.05). Higher concentrations of mono (3-carboxypropyl) phthalate (MCPP), a non-specific metabolite of several high molecular-weight phthalates, measured post-implantation were associated with increased risk of earlier birth, i.e. shorter length of gestation, HR: 1.59, CI: 1.02, 2.49.

CONCLUSIONS

Early gestational exposure to DEHP and possibly other high-molecular weight phthalates, (as reflected by urinary MCPP concentrations) may influence the length of pregnancy. Such effects could have consequences for neonatal and maternal health.

Authors+Show Affiliations

Epidemiology Branch, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Mailstop A3-05, Research Triangle Park, NC, 27709, USA. helen.chin@nih.gov.Epidemiology Branch, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Mailstop A3-05, Research Triangle Park, NC, 27709, USA.Epidemiology Branch, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Mailstop A3-05, Research Triangle Park, NC, 27709, USA.Biostatistics Branch, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Research Triangle Park, NC, 27709, USA.Epidemiology Branch, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Mailstop A3-05, Research Triangle Park, NC, 27709, USA.Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Mail Stop F-17, 4770 Buford Highway, NE, Atlanta, GA, 30341-3724, USA.Westat, 1009 Slater Rd # 110, Durham, NC, 27703, USA.Epidemiology Branch, National Institute of Environmental Health Sciences, 111 T W Alexander Drive, Mailstop A3-05, Research Triangle Park, NC, 27709, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

31470855

Citation

Chin, Helen B., et al. "Association of Urinary Concentrations of Early Pregnancy Phthalate Metabolites and Bisphenol a With Length of Gestation." Environmental Health : a Global Access Science Source, vol. 18, no. 1, 2019, p. 80.
Chin HB, Jukic AM, Wilcox AJ, et al. Association of urinary concentrations of early pregnancy phthalate metabolites and bisphenol A with length of gestation. Environ Health. 2019;18(1):80.
Chin, H. B., Jukic, A. M., Wilcox, A. J., Weinberg, C. R., Ferguson, K. K., Calafat, A. M., McConnaughey, D. R., & Baird, D. D. (2019). Association of urinary concentrations of early pregnancy phthalate metabolites and bisphenol A with length of gestation. Environmental Health : a Global Access Science Source, 18(1), 80. https://doi.org/10.1186/s12940-019-0522-2
Chin HB, et al. Association of Urinary Concentrations of Early Pregnancy Phthalate Metabolites and Bisphenol a With Length of Gestation. Environ Health. 2019 08 30;18(1):80. PubMed PMID: 31470855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of urinary concentrations of early pregnancy phthalate metabolites and bisphenol A with length of gestation. AU - Chin,Helen B, AU - Jukic,Anne Marie, AU - Wilcox,Allen J, AU - Weinberg,Clarice R, AU - Ferguson,Kelly K, AU - Calafat,Antonia M, AU - McConnaughey,D Robert, AU - Baird,Donna D, Y1 - 2019/08/30/ PY - 2019/02/26/received PY - 2019/08/23/accepted PY - 2019/9/1/entrez PY - 2019/9/1/pubmed PY - 2020/3/17/medline KW - Delivery KW - Pregnancy KW - Pregnancy length SP - 80 EP - 80 JF - Environmental health : a global access science source JO - Environ Health VL - 18 IS - 1 N2 - BACKGROUND: Environmental exposure to phthalates and bisphenol A (BPA) may have endocrine disrupting effects that alter length of gestation. We assessed the association between the urinary concentrations of 11 phthalate metabolites and BPA with length of gestation in a cohort of women followed from before conception with daily 1st-morning urinary hormone measures that identified day of implantation. METHODS: Pre-implantation and post-implantation urinary phthalate metabolites and BPA concentrations were measured in pooled urine samples designed to limit single-measure variability due to the likely episodic nature of these exposures and the short half-life of these compounds. We estimated associations between these exposure biomarkers early in pregnancy with length of gestation from implantation to spontaneous birth. Cox proportional hazards models were used to estimate the hazard of birth among 125 naturally-conceived, singleton live births with censoring for medical interventions that artificially shortened pregnancy. RESULTS: Higher concentrations of mono (2-ethyl-5-hydroxyhexyl) phthalate (a metabolite of di (2-ethylhexyl) phthalate (DEHP)) during the pre-implantation window were associated with reduced probability of birth, i.e., longer gestations (hazard ratio (HR): 0.55, 95% CI: 0.35, 0.86; p = 0.01). The HR for the molar sum of the four DEHP metabolites measured showed a similar association (HR: 0.67, 95% CI: 0.43, 1.05). Higher concentrations of mono (3-carboxypropyl) phthalate (MCPP), a non-specific metabolite of several high molecular-weight phthalates, measured post-implantation were associated with increased risk of earlier birth, i.e. shorter length of gestation, HR: 1.59, CI: 1.02, 2.49. CONCLUSIONS: Early gestational exposure to DEHP and possibly other high-molecular weight phthalates, (as reflected by urinary MCPP concentrations) may influence the length of pregnancy. Such effects could have consequences for neonatal and maternal health. SN - 1476-069X UR - https://www.unboundmedicine.com/medline/citation/31470855/Association_of_urinary_concentrations_of_early_pregnancy_phthalate_metabolites_and_bisphenol_A_with_length_of_gestation_ L2 - https://ehjournal.biomedcentral.com/articles/10.1186/s12940-019-0522-2 DB - PRIME DP - Unbound Medicine ER -